Navigation Links
Greater representation of elderly patients in Phase III trials are needed
Date:2/22/2013

DENVER The median age of patients diagnosed with advanced nonsmall-cell lung cancer (NSCLC) has steadily increased over the recent years and is presently 70 years. Despite this, the elderly are significantly underrepresented in clinical trials. A recent study published in the March 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, investigated the degree to which exclusion or underrepresentation of elderly occurs in practice-changing clinical trials in advanced NSCLC. Researchers conclude that greater representation of elderly patients in phase III trials is required to better define evidence-based paradigms in the increasingly elderly NSCLC population.

Researchers did an extensive literature search, included articles for review if they were phase III, involved systemic therapy alone, studied advanced NSCLC and were conducted between 1980 and 2010. A total of 248 studies were identified and their full text reviewed by the authors.

Among the 100 most cited trials, 33 percent excluded elderly patients in their trial design. The average reported median patient age in those trials was 60.9 years.

The authors "have clearly demonstrated that a significant proportion of highly cited phase III clinical trials in advanced NSCLC overtly exclude elderly patients." They recommend that a greater emphasis be placed on recruiting clinical trial patients with age demographics that better represent the median age of the advanced NSCLC population.


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. Bullied Children at Greater Risk for Self-Harm, Study Finds
2. Greater numbers of highly educated women are having children, bucking recent history
3. Irregular Heartbeat Poses Greater Stroke Risk for Women Than Men
4. Hepatitis C Causing Liver Damage in Greater Numbers: Study
5. Unemployed Americans face greater risk of mortality: UBC study
6. Greater L.A. Heating Up, Climate Experts Predict
7. Greater availability of neurosurgeons could reduce risk of death from motor vehicle accidents
8. Early treatment could mean greater earning potential for people with HIV
9. Men Have a Greater Lifetime Risk for Kidney Failure: Study
10. More Friends, Greater Well-Being at Midlife?
11. Ancestral link places Mexican-Americans at greater risk for metabolic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... 22, 2017 , ... Pullano Law Offices, a Chicago personal injury law firm, ... selected to serve as President of the North Suburban Bar Association for 2017-2018. Mr. ... hosted by the NSBA at the North Shore Country Club in Glenview, IL, on ...
(Date:9/22/2017)... , ... September 22, 2017 , ... ... Rob Lowe, explores the world of Alzheimer’s. Alzheimer’s is a disease estimated to ... This according to information published by the Alzheimer’s Association, a leading voice in ...
(Date:9/22/2017)... ... September 22, 2017 , ... The freshly ... customers’ doorstep. According to Smart Mart, customers can now order vegetable, fruit, snacks, ... and customers can find clothing at discounted prices. Apart from this, Smart Mart ...
(Date:9/21/2017)... , ... September 21, 2017 , ... 38-Year-Old Plastic Surgeon ... Center in Naples, Florida is pleased to announce that Plastic Surgeon Kiranjeet Gill has ... 40 Under 40 is an annual award that was started in 2003 to ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... **An FDAnews Management Report**, http://www.fdanews.com/products/54818-promotional-communication      , In the competitive world of ... can get while staying in compliance with FDA rules. , The FDA has ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017 NeuroRx, a clinical stage ... Ideation and Behavior (ASIB), has been granted Fast Track status ... therapy of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine + ... pivotal trial of this sequential therapy targeting patients who are ... ...
(Date:9/5/2017)... Sept. 5, 2017  Just 18 months after its ... pleased to announce the appointment of three new senior ... , Dominic Jones-Phillips and James Wright ... Tammy Wynne ... market access writers. She has over ten years, experience ...
(Date:8/31/2017)... , Aug. 31, 2017 PM360,s ... must-read guide to the latest innovations happening across the ... industry publication to focus on providing a comprehensive look ... the issue covers the most innovative companies, startups, divisions, ... "Everyone in this industry ...
Breaking Medicine Technology: