Navigation Links
Grb2 holds powerful molecular signaling pathway in check
Date:6/22/2012

HOUSTON - Once considered merely a passive link between proteins that matter, Grb2 - pronounced "grab2" - actually lives up to its nickname with its controlling grip on an important cell signaling pathway, scientists at The University of Texas MD Anderson Cancer Center report in the June 22 issue of Cell.

"Grb2 is a switch that controls normal signaling through the fibroblast growth factor receptor (FGFR)," said the paper's senior author, John Ladbury, Ph.D., professor in MD Anderson's Department of Biochemistry and Molecular Biology.

"Perhaps the best way to think about it is that Grb2 controls cell homeostasis (stable state) before a growth factor binds to FGFR, activating this molecular pathway," Ladbury said.

In addition to discovering a fundamental aspect of FGFR signaling, the researchers' discovery points to a potential explanation of why genomic alterations found in breast, bladder and gastric cancers and melanoma might promote cancer formation and growth, Ladbury noted.

FGFR has a docking station to receive growth factors on the cell surface, and another internal region that passes the growth factor signal on to proteins inside the cell by attaching phosphate groups to them.

FGFR employs phosphorylation to regulate a number of important processes, including the cell cycle, cell proliferation and migration. When some of these pathways become overactive, they can contribute to cancer growth and survival.

Like "a car idling in neutral" ready to go

Grb2's full name reflects its location: growth factor receptor-bound protein 2. In the great rush of molecular signaling pathway mapping in the 1990s, Ladbury noted that Grb2 was labeled an "adaptor protein," one that has no activity of its own apart from connecting to other proteins.

Mapping ran way ahead of figuring out each protein's function in a signaling pathway, Ladbury said, and scientists are still catching
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. 1 in 3 households misreports smoke alarm coverage
2. Moving 3D computer model of key human protein is powerful new tool in fight against cancer
3. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
4. Molecular probes identify changes in fibronectin that may lead to disease
5. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
6. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
7. Scientists discover distinct molecular subtype of prostate cancer
8. New molecular structure offers first picture of a protein family vital to human health
9. Inhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment
10. Cellular pathway linked to diabetes, heart disease
11. Unusual protein helps regulate key cell communication pathway
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grb2 holds powerful molecular signaling pathway in check
(Date:5/21/2013)... 2013) A paper recently published in the ... physicians and scientists at the University of Colorado School ... for pulmonary fibrosis can be used to identify individuals ... looked at a fairly common variant of the gene ... the mucous produced by the bronchial tubes. While this ...
(Date:5/21/2013)... adenoids and tonsils, is performed 500,000 times a year ... children with obstructive sleep apnea. However, the procedure,s ... behavior, sleep apnea symptoms, and quality of life has ... led by Susan Redline, MD, MPH, director of ... Clinic Director of the Division of Sleep Medicine at ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Two executives ... Guidance (SBG) will identify which strategies can be most ... high-quality care to the members who are taking them, ... Services, Inc., “How to Manage Specialty Drugs to ... pharmaceuticals are now the main driver for rising prescription ...
(Date:5/21/2013)... 22, 2013 About one in six ... Fertility Clinics industry one of the fastest growing ... who are unable to conceive naturally through a variety ... which is in-vitro fertilisation (IVF) cycles. Over the past ... Australia has increased by 4.4% per annum to a ...
(Date:5/21/2013)... PHILADELPHIA ─ A study of veterans at high risk ... (LDCT) can be highly effective in helping clinicians spot ... patients, may indicate the earliest stages of the disease. ... of a conventional CT scan. , Results of the ... Conference. , "Lung cancer is the leading cause of ...
Breaking Medicine News(10 mins):Health News:Researchers find genetic risk factor for pulmonary fibrosis 2Health News:Early removal of adenoids and tonsils can help pediatric sleep apnea symptoms 2Health News:Consulting Firm Execs to Discuss Strategies for Effective Management of Specialty Drugs in AIS’s May 30 Webinar 2Health News:Fertility Clinics in Australia Industry Market Research Report Now Available from IBISWorld 2Health News:Fertility Clinics in Australia Industry Market Research Report Now Available from IBISWorld 3Health News:Low radiation scans help identify cancer in earliest stages 2Health News:Low radiation scans help identify cancer in earliest stages 3
... Today,s adolescents have been characterized as the most materialistic ... derive self-worth from owning luxury handbags and the latest ... the increased level of teen materialism. In fact, research ... of behavior and therefore, highly materialistic parents and peers ...
... ... new CEO and President named at local hospitals , ... Ft. Lauderdale, FL (PRWEB) March 24, 2010 -- After leading ... percent in the nation for clinical excellence, John C. Johnson has been named to a ...
... ... Existing Affiliates, Launches 1DentalBroker.com. , ... (PRWEB) March 24, 2010 -- 1Dental.com , a ... to help promising affiliates connect more dental patients to substantial savings through the ...
... ... University Health Sciences Center School of Medicine has designed a first-of-its-kind ... Family Medicine Accelerated Track (FMAT), has been approved by the Liaison ... summer. FMAT students will complete their training one year earlier than ...
... ... support U.S. healthcare industry goals for standardized product identification. Report summarizes experiences of ... ... -- A new industry report summarizing the experiences of 14 healthcare early adopters ...
... seen in 1918, with implications for vaccine development, scientists ... 2009 H1N1 "swine flu" virus shares remarkable similarities with ... two teams of scientists report. , These structural similarities ... affected by H1N1 during the latest pandemic, researchers say, ...
Cached Medicine News:Health News:Counteracting teens' logo lust 2Health News:Holy Cross And Mercy Hospitals Announce Staff Promotions 2Health News:Holy Cross And Mercy Hospitals Announce Staff Promotions 3Health News:Holy Cross And Mercy Hospitals Announce Staff Promotions 4Health News:Holy Cross And Mercy Hospitals Announce Staff Promotions 5Health News:Holy Cross And Mercy Hospitals Announce Staff Promotions 6Health News:Holy Cross And Mercy Hospitals Announce Staff Promotions 7Health News:1Dental.com Announces Enhanced Broker-Affiliate Program 2Health News:1Dental.com Announces Enhanced Broker-Affiliate Program 3Health News:Primary Care Physician Shortage: Texas Tech University Health Sciences Center Has the Solution 2Health News:Primary Care Physician Shortage: Texas Tech University Health Sciences Center Has the Solution 3Health News:Primary Care Physician Shortage: Texas Tech University Health Sciences Center Has the Solution 4Health News:Healthcare Early-Adopters Issue Industry Report for Using Data Synchronization 2Health News:Healthcare Early-Adopters Issue Industry Report for Using Data Synchronization 3Health News:Healthcare Early-Adopters Issue Industry Report for Using Data Synchronization 4Health News:Healthcare Early-Adopters Issue Industry Report for Using Data Synchronization 5Health News:H1N1 Virus Yields Up More Secrets 2
(Date:5/21/2013)... , May 21, 2013  Healthcare organizations expanding into ... Russia , India ... there are no shortcuts.  This is proving particularly challenging, ... States.  Companies must change the dialogue around BRIC, as ... local needs, and building regional partnerships to build a ...
(Date:5/21/2013)... , May 21, 2013 Reportlinker.com ... is available in its catalogue: ... Reimbursement Scenario for Medical Devices in the ...   Changing Regulatory and ... US Market   ...
(Date:5/21/2013)... and HENDERSONVILLE, N.C. , ... bidding procurement program for home medical equipment is ... North Carolina to lay off employees or ... quality of service and products received by Medicare beneficiaries, ... the defective and dangerous program, the Centers for ...
Breaking Medicine Technology:Frost & Sullivan: BRIC is Not Delivering Promises of High Growth in Healthcare Markets 2Frost & Sullivan: BRIC is Not Delivering Promises of High Growth in Healthcare Markets 3Frost & Sullivan: BRIC is Not Delivering Promises of High Growth in Healthcare Markets 4Changing Regulatory and Reimbursement Scenario for Medical Devices in the US Market 2Changing Regulatory and Reimbursement Scenario for Medical Devices in the US Market 3Changing Regulatory and Reimbursement Scenario for Medical Devices in the US Market 4North Carolina Business Owners At Risk Because Of Defective Medicare Bidding Program 2North Carolina Business Owners At Risk Because Of Defective Medicare Bidding Program 3North Carolina Business Owners At Risk Because Of Defective Medicare Bidding Program 4
... The FoamWrap ACTION Elbow Wrap replaces ... tennis players, golfers, and others experiencing epicondylitis. ... of application and non-bulky fit. Two overlay ... needed. Breathable, non-slip foam lining holds the ...
... Extender Arm Brace is designed to handle ... ligament trauma. The Bledsoe Extender Arm Brace ... locked control of the elbow is desired. ... Brace can be formed, fitted and adjusted ...
... This controlled stretch ankle support helps reduce ... of motion. It is easy to apply ... its slim design fits easily into shoes. ... the ankle, and provide side-to-side support and stability. ...
... splint may be used for either therapeutic ... It is effective in stabilizing the ankle ... cast removal. The rigid pre-bent metal ... support. The stays also help the ...
Medicine Products: