Navigation Links
Grb2 holds powerful molecular signaling pathway in check
Date:6/22/2012

HOUSTON - Once considered merely a passive link between proteins that matter, Grb2 - pronounced "grab2" - actually lives up to its nickname with its controlling grip on an important cell signaling pathway, scientists at The University of Texas MD Anderson Cancer Center report in the June 22 issue of Cell.

"Grb2 is a switch that controls normal signaling through the fibroblast growth factor receptor (FGFR)," said the paper's senior author, John Ladbury, Ph.D., professor in MD Anderson's Department of Biochemistry and Molecular Biology.

"Perhaps the best way to think about it is that Grb2 controls cell homeostasis (stable state) before a growth factor binds to FGFR, activating this molecular pathway," Ladbury said.

In addition to discovering a fundamental aspect of FGFR signaling, the researchers' discovery points to a potential explanation of why genomic alterations found in breast, bladder and gastric cancers and melanoma might promote cancer formation and growth, Ladbury noted.

FGFR has a docking station to receive growth factors on the cell surface, and another internal region that passes the growth factor signal on to proteins inside the cell by attaching phosphate groups to them.

FGFR employs phosphorylation to regulate a number of important processes, including the cell cycle, cell proliferation and migration. When some of these pathways become overactive, they can contribute to cancer growth and survival.

Like "a car idling in neutral" ready to go

Grb2's full name reflects its location: growth factor receptor-bound protein 2. In the great rush of molecular signaling pathway mapping in the 1990s, Ladbury noted that Grb2 was labeled an "adaptor protein," one that has no activity of its own apart from connecting to other proteins.

Mapping ran way ahead of figuring out each protein's function in a signaling pathway, Ladbury said, and scientists are still catching
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. 1 in 3 households misreports smoke alarm coverage
2. Moving 3D computer model of key human protein is powerful new tool in fight against cancer
3. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
4. Molecular probes identify changes in fibronectin that may lead to disease
5. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
6. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
7. Scientists discover distinct molecular subtype of prostate cancer
8. New molecular structure offers first picture of a protein family vital to human health
9. Inhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment
10. Cellular pathway linked to diabetes, heart disease
11. Unusual protein helps regulate key cell communication pathway
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grb2 holds powerful molecular signaling pathway in check
(Date:4/18/2015)... 18, 2015 Thousand of DePuy Pinnacle ... of individuals who were allegedly harmed by a metal-on-metal ... forward in the U.S. District Court, Northern District of ... Court has amended an earlier Case Management Order to ... things, the new amendment permits the claims of up ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 On April 14th, ... Threat Report , which they say, “exposes a tactical shift ... new malware variants were introduced in 2014 - almost a ... Zero Day threats to be identified and patched by prominent ... abundantly clear that doing business in a digital world can ...
(Date:4/18/2015)... 18, 2015 PHOENIX, ARIZONA – In ... with 11 other secure destruction professionals across the United ... (CSDS). He will now display “CSDS” as a professional ... before the National Association of Information Destruction 2015 Annual ... Grapevine, Texas. Of the 20 people who took the ...
(Date:4/17/2015)... John Evans, a Gardant affordable assisted ... from 2 p.m. to 3 p.m. on April 24. ... Ct. in Pekin, Illinois, serves older adults of all ... to maintain their independence. , Becky Baker will entertain ... be served during the luau. , For more information, ...
(Date:4/17/2015)... April 17, 2015 Riviera Magazine ... Kevin Sadati of the Gallery of Cosmetic Surgery ... top beauty experts. The publication focused on his ... stem cell fat grafting, eyelid surgery, laser resurfacing and ... plastic surgery has resulted in thousands of satisfied ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3
... in applied physics, computer engineering, infectious diseases, emergency ... 7-foot-tall, $10,000 shower-cubicle-shaped device that automatically sanitizes in ... the highly trafficked hospital emergency department. The ... all shapes and sizes, from intravenous line poles ...
... the blow fly is a true artist of flight. Suddenly ... its own axis, and making precise, pinpoint landings all ... eyesight helps to keep it from losing orientation as it ... process the multiplicity of images and signals so rapidly and ...
... , COLUMBIA, S.C., July 31 ... weighing the money-saving benefits of including international medical travel coverage ... are concerned about possible risks associated with offering such options. ... travel facilitator Companion Global Healthcare Inc. today announced an agreement ...
... , , PITTSBURGH, July 31 ... Festival kicks off Saturday, August 15, 12 p.m., at the ... Fund, which helps support cardiac research at Children,s Hospital of Pittsburgh ... high honors student at Penn Trafford High School, who suddenly passed ...
... , A Comprehensive Web Guide on Lung Cancer at ... July 31 Today, Lung Cancer Alliance (LCA), the only ... with or at risk for lung cancer, announced the launch of its ... Resource Center , a web ...
... vision-robbing disease , FRIDAY, July 31 (HealthDay News) -- A ... cause of blindness, has been identified by scientists. , The ... the repair of damaged proteins in the eye. Expression of ... can clump together and cause the eye lens to become ...
Cached Medicine News:Health News:Prototype, 7-foot-tall sanitizer automates disinfection of hard-to-clean hospital equipment 2Health News:Robotics insights through flies' eyes 2Health News:Robotics insights through flies' eyes 3Health News:Robotics insights through flies' eyes 4Health News:New Policies Protect Employers, Workers Who Choose Global Health Care 2Health News:Lung Cancer Alliance Launches Online 'Early Interventions Resource Center' 2
(Date:4/17/2015)... Sigma-Aldrich Corporation (NASDAQ: ... Technology company, today announced the opening of its ... state-of-the-art Cell Culture Technical Center in Singapore.  Located ... customized support to meet customer needs, leveraging the ... new Technical Center will significantly enhance our ability ...
(Date:4/17/2015)... 17, 2015 TWi Pharmaceuticals, Inc. ("TWi", Stock ... USA , has obtained state sales ... It has been in close contact with the major ... have its own label specialty generic products sold through ... pharma market. According to IMS Health, the ...
(Date:4/16/2015)... Mindray Medical International Limited (NYSE: MR ... medical devices worldwide, announced today that it has ... Report on Form 20-F that included audited financial ... electronic version of Mindray,s Annual Report on Form ... at  http://ir.mindray.com  or  http://www.sec.gov . Investors ...
Breaking Medicine Technology:Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 2Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 3Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 4Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 5Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2
This compact photomicrographic system assures simple operation to achieve the exposure accuracy required for sophisticated photomicrography in most research and clinical environments....
... for Geometric Data Hemastainer. Formulated ... are quality control tested on ... proper staining and absence of ... for a minimum of eight ...
... Methylene Blue, a reticulocyte stain, ... This stain produces vividly-colored reticulocyte ... any counter-staining. New Methylene Blue ... sizes, 30 ml (convenient dropper ...
Wright Stain Solutions...
Medicine Products: