Navigation Links
Grb2 holds powerful molecular signaling pathway in check
Date:6/22/2012

HOUSTON - Once considered merely a passive link between proteins that matter, Grb2 - pronounced "grab2" - actually lives up to its nickname with its controlling grip on an important cell signaling pathway, scientists at The University of Texas MD Anderson Cancer Center report in the June 22 issue of Cell.

"Grb2 is a switch that controls normal signaling through the fibroblast growth factor receptor (FGFR)," said the paper's senior author, John Ladbury, Ph.D., professor in MD Anderson's Department of Biochemistry and Molecular Biology.

"Perhaps the best way to think about it is that Grb2 controls cell homeostasis (stable state) before a growth factor binds to FGFR, activating this molecular pathway," Ladbury said.

In addition to discovering a fundamental aspect of FGFR signaling, the researchers' discovery points to a potential explanation of why genomic alterations found in breast, bladder and gastric cancers and melanoma might promote cancer formation and growth, Ladbury noted.

FGFR has a docking station to receive growth factors on the cell surface, and another internal region that passes the growth factor signal on to proteins inside the cell by attaching phosphate groups to them.

FGFR employs phosphorylation to regulate a number of important processes, including the cell cycle, cell proliferation and migration. When some of these pathways become overactive, they can contribute to cancer growth and survival.

Like "a car idling in neutral" ready to go

Grb2's full name reflects its location: growth factor receptor-bound protein 2. In the great rush of molecular signaling pathway mapping in the 1990s, Ladbury noted that Grb2 was labeled an "adaptor protein," one that has no activity of its own apart from connecting to other proteins.

Mapping ran way ahead of figuring out each protein's function in a signaling pathway, Ladbury said, and scientists are still catching
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. 1 in 3 households misreports smoke alarm coverage
2. Moving 3D computer model of key human protein is powerful new tool in fight against cancer
3. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
4. Molecular probes identify changes in fibronectin that may lead to disease
5. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
6. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
7. Scientists discover distinct molecular subtype of prostate cancer
8. New molecular structure offers first picture of a protein family vital to human health
9. Inhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment
10. Cellular pathway linked to diabetes, heart disease
11. Unusual protein helps regulate key cell communication pathway
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grb2 holds powerful molecular signaling pathway in check
(Date:5/24/2015)... 24, 2015 Medicx Media Solutions ... strategy executive Jay Krihak as its head of ... ramp up its expertise and leadership position in ... and Health sectors. , Krihak is an experienced, ... recently, Krihak led sales planning teams for mobile ...
(Date:5/24/2015)... CA (PRWEB) May 24, 2015 ... clear indicator that the single best option for avoiding ... reveals that fitness level was the single most powerful ... for variables such as diabetes and family history of ... of maintaining lifelong heart and lung fitness. , The ...
(Date:5/23/2015)... On May 13, Nithyananda Yoga Foundation organized a ... learned through meditation and initiation at Special Holistic School ... Yogamaatha, a nine-year-old girl from North Carolina, stunned an ... the 2015 Business Advocacy Summit at Capitol Hill in ... In a demonstration that lasted three hours, Yogamaatha was ...
(Date:5/23/2015)... San Diego, CA (PRWEB) May 23, 2015 ... businesses, especially small businesses, are finding it increasingly difficult ... Those businesses which fail to provide adequate insurance for ... healthcare for businesses been such an integral part of ... provide more affordable healthcare for businesses, Online USA Doctors ...
(Date:5/23/2015)... On May 16, the team at Farrell’s eXtreme ... mud obstacle run that raised funds for multiple sclerosis. ... the reason we participated was to support people living with ... eXtreme Bodyshaping. “One-hundred percent of the funds raised go to ... not only attended by eXtreme Bodyshaping staff, but members of ...
Breaking Medicine News(10 mins):Health News:Medicx Media Solutions Expands Executive Team 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 3Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2
... March 8. According to statistics over one lac people Indians ... per cent die as they do not get timely treatment. ... Kidney Health Check-up package in connection with World Kidney Day-2007. ... includes consultation and urine analysis for random glucose and creatinine. ...
... with vitamins and minerals as a large number of people ... link to obesity. // ,Soda business remains a ... for bottled water, sparkling juices and green tea drinks, reported ... ,In 2005, the amount of soda sold in the US ...
... sunshine is good for the development of the human body. A ... this idea. The study concluded that getting plenty of sunshine could ... But it cautions that too much of it could actually turn ... Dr Chantal Mathieu, found that low levels of vitamin D could ...
... celebrate the emancipation and empowerment of women, Rashmila Shakya has ... of being a goddess, she now has the additional laurel ... she was only four, Rashmila, now 24, was worshipped and ... living goddess., ,The tradition of the Kumari is one ...
... least 100,000 medical tourists in the next three years, ... its health//. ,Foreigners are arriving in Kerala's ... dental treatments, cosmetology, hip and knee replacement, ophthalmology, voice ... Health Tourism (KTH)-2007 fair, to be held in Kochi ...
... stem cells and spur their growth and survival could ... MIT have created a new tissue-engineering material that could ... in cell-transplant therapies. Scientists are now testing the material ... heal fractures. ,"Creating instructional biomaterials like this ...
Cached Medicine News:Health News:Nepal Gets Its First Graduate Goddess 2Health News:Kerala Sees Medical Tourism Soaring 2Health News:Healing Bone With Stem Cells 2
(Date:5/22/2015)... KING OF PRUSSIA, Pa. , May 22, ... awarded CSL Behring its 2015 Corporate Leadership Award ... advancing science and improving the care of the bleeding disorders ... CEO and Managing Director, CSL Limited, during the NHF Annual ... on May 21. "The National Hemophilia Foundation is ...
(Date:5/22/2015)...  The Mesothelioma Victims Center is incredibly passionate ... the best possible compensation, and they are also extremely ... cancer caused by exposure to asbestos or their ... treatment options such as a recent possible medical breakthrough. ... Center anytime at 866-714-6466. http://MesotheliomaVictimsCenter.Com ...
(Date:5/22/2015)... Research and Markets( http://www.researchandmarkets.com/research/28m7nx/guide_to_prepare ) has ... Prepare Application Dossiers for Oversea Medical device registration ... report to their offering. The Chinese ... of the most growth potentiality, which is attracting ... producers to penetrate such market. It is estimated ...
Breaking Medicine Technology:National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 5China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 3
... Approximately one-half of all infants are infected with the respiratory ... all children have been infected at least once by the time ... have discovered what makes RSV such a severe and persistent illness. ... his team have discovered that RSV prompts the release of a ...
... Australia, Sept. 3 Cytopia Limited,s (ASX: CYT) Investigational New ... Drug Administration (FDA) review. CYT387 is a small-molecule oral JAK1/JAK2 ... IND application is now active and Cytopia is able to ... , , CYT387 will be the second ...
Cached Medicine Technology:Researchers Find Common Respiratory Virus Hijacks Lung Cells to Stay Alive 2Researchers Find Common Respiratory Virus Hijacks Lung Cells to Stay Alive 3Cytopia's CYT387 Receives FDA Clearance to Start US Clinical Trials 2
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
... Surgical Microscope Accessories includes digital camera ... optic cables, and fiberoptic retrofits. The ... directly to a Zeiss® style beamsplitter ... mount the Photo Adaptor onto other ...
Medicine Products: