Navigation Links
Gray matter under attack in multiple sclerosis
Date:4/30/2009

Autoimmune disease is a condition in which the immune system attacks the body's own material just as aggressively as it would attack a foreign pathogen. Multiple sclerosis, MS for short, is just one such autoimmune disease, and is one of the most common neurological diseases in the 20 to 30 years age group. The disease can have very severe consequences for those afflicted, since the body's defenses attack the central nervous system. It has long been assumed that myelin is the most important target for the misdirected immune response. This white, fat-rich protective layer of specialized cells enshrouds the long extensions of neurons. However, the central nervous systems of MS patients also exhibit damage in the gray matter, where the nerve cell bodies are located. How the patient's disability develops depends greatly on the damage of the gray matter. An international group headed by medical scientist Professor Edgar Meinl of LMU Munich has now discovered a possible connection: The protein Contactin-2 is produced both in the myelin sheathing and by neurons in the gray matter and is attacked by misdirected immune factors. "Our results suggest that these processes also play a role in MS patients," says Meinl. "It could even be that proteins existing both in myelin and in the gray matter are in fact the critical points of attack."

Multiple sclerosis often advances in phases, where nerve fibers are successively and irreversibly destroyed by attacks from certain immune cells so-called T-lymphocytes. The axons that make up nerve fibers are sheathed in myelin. This protective layer consists of individual cells that wrap around the long extensions of the neurons to insulate them and to allow signals to propagate all the way along the nerve cells. MS first causes in an irrecoverable loss of myelin, and then ultimately to the demise of the neurons thus exposed.

"It is the irreversible destruction of axons in particular that causes the lasting disabili
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
089-218-02706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Timing May Matter in Organ Donation Decisions
2. Your Decisions Matter: San Diego Hospice Encourages You to Make Your Healthcare Decisions Known
3. Do You Want to Feel Inner Peace and Joy No Matter What is Happening in Your Life?
4. Combat Injuries: A Matter of Life and Death
5. Sodexo Receives 2009 Disability Matters Award
6. When it comes to intelligence, size matters
7. Starkey Hearing Foundation Partners With GRAMMY Foundation(R) to Announce SoundMatters(TM) Initiative: GRAMMY-Nominated Artist Taylor Swift, Along With Emerging Artists Crosby Loggins, Jimmy Wayne and GRAMMY-Nominated Sara Bareilles Lead the Way in the Pr
8. The Museum of Modern Arts Meet Me at MoMA Program for People with Alzheimers and Other Dementia Featured in National Center for Creative Agings Creativity Matters Symposium on Health, Wellness, and the Arts
9. National Center for Creative Aging Features Timeslips in Creativity Matters Symposium on Health, Wellness, and the Arts
10. Thomson Reuters Publishes Pharma Matters White Paper, The Five Myths of Generic Competition
11. National Center for Creative Aging Presents Creativity Matters Symposium on Health, Wellness, and the Arts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... (PRWEB) December 17, 2014 Dr. Myo Nwe ... Weight Loss Diet of the Future” and co-founder of the ... her book, Dr. Nwe takes a broad look at the ... hold up under scientific scrutiny. On film and in television ... emphasized mostly toward the social aspects and played for basic ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 In its ... and its Argus Claim Review division have recently ... the most common ways savings are achieved on behalf ... attributes millions of dollars in savings to Argus each ... 2013. , As explained by Tom Doney, Cypress president ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. ... diseases, one worrisome phenomenon is when an illness that originated ... known as zoonosis -- is not uncommon and keeps researchers ... animal-borne disease might make inroads into the human population. ... and the culprits in this case were guinea pigs. More ...
(Date:12/17/2014)... Amy Norton HealthDay Reporter ... long been believed to improve overall health, but a growing ... the heart, a new review finds. In fact, the ... brisk walking, said lead researcher Paula Chu, a doctoral candidate ... review, of 37 clinical trials, found that people randomly assigned ...
(Date:12/15/2014)... Main Street Dental Team ( http://www.MainStreetDentalTeam.com ), Unionville’s first ... study providing evidence on the impact of 100% pure ... Sufficient enough evidence already exists showing a negative link ... with the onset of tooth decay. One question that ... 100% fruit juice, meaning it is completely natural with ...
Breaking Medicine News(10 mins):Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Out-of-Network & Medical Necessity Reviews among Top Ways TPA Identifies Significant Medical Claim Savings 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 2Health News:Guinea Pigs Can Be Source of Serious Strep Infection 3Health News:Yoga May Cut Heart Disease Risk Factors 2Health News:Yoga May Cut Heart Disease Risk Factors 3Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Comments on New Study Relating Pure Fruit Juice to Poor Oral Hygiene 2
... NEW YORK, March 4, 2011 Despite significant investment in ... has seen a marked decline in the number of ... at the New York Academy of Sciences on Wednesday, ... experts in clinical, translational, and basic neuroscience to address ...
... By Ellin Holohan HealthDay Reporter , THURSDAY, ... chance of getting a kidney transplant than whites do, claims ... used to decide who gets which donated organs. The ... that once "waitlisted" for a needed kidney, white patients were ...
... - DNA provides the instruction manual for all life ... and bad messages are sent leading to the creation ... , Paul Doetsch, PhD, professor of radiation oncology and ... Winship Cancer Institute and Damien Brgeon, PhD, at Institut ...
... Dr. David Levin, Professor of Molecular & Cell ... Dental Medicine and Professor of Microbiology at Boston University ... mechanism for the regulation of gene expression. The study ... Paf1 Complex Blocks Sen1-Mediated Premature Transcription Termination," appears in ...
... on producing radiation inside a tumour using,boron-10 and thermal ... help of a special carrier substance (phenylalanine), after which ... react with the boron to generate high-LET radiation, which ... treatment sessions may be sufficient to destroy a tumour, ...
... Congress on Osteoporosis & Osteoarthritis - the most ... held in Valencia,s award-winning ,Palacio de Congresos, from ... to take advantage of lower registration fees. ... world,s top bone experts, Learn about key topics in ...
Cached Medicine News:Health News:White Patients Most Likely to Get Kidney Transplants: Study 2Health News:White Patients Most Likely to Get Kidney Transplants: Study 3Health News:Nature Reviews Cancer article traces possible role of damaged DNA in tumor development 2Health News:Novel mechanism for control of gene expression revealed 2Health News:BNCT, a new-generation radiation treatment, is effective in advanced head and neck cancer 2
(Date:12/15/2014)... BRIDGEWATER, N.J. , Dec. 15, 2014   ... SAN and NYSE: SNY) are collaborating with nationally-recognized patient ... Counts , an awareness program that will gauge how ... risks associated with high LDL-C (bad cholesterol).  American adults ... to take a brief poll and answer a few ...
(Date:12/15/2014)... --  DaVita HealthCare Partners Inc.  (NYSE: ... most innovative health care communities, today announced that ... Research  (DCR) and  HealthCare Partners Clinical Research , will ... research and data analytics services, specifically in patients ... disease (ESRD), as well as primary care and ...
(Date:12/13/2014)... December 12, 2014 ... the addition of the  "Global Catheters Market ... Global Trends, Company Profiles, Analysis, Segmentation and ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... up of medical grade material such as ...
Breaking Medicine Technology:Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 2DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 3DaVita Clinical Research and HealthCare Partners Clinical Research to Merge and Expand Clinical Trials and Data Analytics Capabilities 4Global Catheters Market (Product Types and Geography) - Forecast to 2020 2Global Catheters Market (Product Types and Geography) - Forecast to 2020 3
... Uroplasty, Inc. (NASDAQ: UPI ), a medical device ... treat voiding dysfunctions, announced today that its President and CEO ... on Tuesday, June 7, 2011.  The ceremony, held at the ... be broadcast live beginning at 3:45 p.m. ET via the ...
... 6, 2011 University Hospitals (UH) Seidman Cancer ... hospital, opens to patients on June 6. The ... cancer-fighting treatments and technology – all in a ... ) The $260 million, 375,000-square-foot ...
Cached Medicine Technology:Uroplasty's Dave Kaysen to Ring NASDAQ Closing Bell 2University Hospitals Seidman Cancer Center Opens: First Cancer Hospital in Northeast Ohio Offers Nation's Most Advanced Technology and Treatments 2University Hospitals Seidman Cancer Center Opens: First Cancer Hospital in Northeast Ohio Offers Nation's Most Advanced Technology and Treatments 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: