Navigation Links
Grapefruit Juice Boosts Anti-Cancer Drug's Effects
Date:4/20/2009

Small study finds 8-ounce glass enhances absorption of rapamycin 3 to 4 times

MONDAY, April 20 (HealthDay News) -- Grapefruit juice boosts the anti-cancer effects of the drug rapamycin, according to a small study that included 25 patients with advanced solid tumors, for which there is no effective treatment.

The patients took 15- to 35-milligram doses of the drug, as a liquid, once a week. After the first week of the study, they also drank a glass (eight ounces) of grapefruit juice immediately after taking the drug and once a day for the rest of the week.

On this regimen, 7 (28 percent) of the patients had stable disease, with little or no tumor growth. One patient who had a partial response, with tumor shrinkage of about 30 percent, was still doing well more than a year after starting the study.

More than half of the patients experienced side effects such as elevated blood sugar levels, diarrhea, low white blood cell counts, and fatigue.

The findings were to be presented Monday at the annual meeting of the American Association for Cancer Research, in Denver.

For many years, doctors and pharmacists have warned patients that grapefruit juice can interfere with enzymes in the body that break down and eliminate certain kinds of drugs.

"Grapefruit juice can increase blood levels of certain drugs three to five times. This has always been considered a hazard. We wanted to see if, and how much, it could amplify the availability, and perhaps the efficacy of rapamycin, a drug with promise for cancer treatment," stud director Dr. Ezra Cohen, a cancer specialist at the University of Chicago Medical Center, said in a center news release.

Rapamycin, also called sirolimus, was originally developed to suppress the immune system and prevent rejection in kidney transplant patients. It's being studied as a cancer drug, because it disrupts a biochemical pathway involved in the growth of new blood vessels needed by tumors to grow. However, less than 15 percent of rapamycin is absorbed by the body when the drug is taken by mouth.

Grapefruit juice contains compounds called furanocoumarins that decrease the breakdown of rapamycin and increase blood levels of the drug three- to fourfold, which means more of the drug can reach its cancer target, according to the researchers.

More information

The U.S. Food and Drug Administration has more about drug interactions.



-- Robert Preidt



SOURCE: University of Chicago Medical Center, news releaes, April 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Grapefruit compound may help combat hepatitis C infection
2. Grapefruit Compound Inhibits Hepatitis C Virus
3. Grapefruit-Heavy Diet Helped Spur Dangerous Clot
4. Grapefruit juice boosts drugs anti-cancer effects
5. Cranberry Could Juice Up Ovarian Cancer Treatment
6. Naked Juice Brings Consumers Happiness by the Billions With First 100% Juice Smoothie Containing Probiotics
7. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
8. Joint Juice Launches New Ready-to-Drink Glucosamine & Vitamin-Enhanced Dietary Supplement Water Nationwide
9. Red wine and grape juice help defend against food-borne diseases, according to MU researchers
10. Joint Juice Helps America Hydrate Its Joints* With New High Value Coupon Offer
11. Citrus juice, vitamin C give staying power to green tea antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Grapefruit Juice Boosts Anti-Cancer Drug's Effects
(Date:5/26/2016)... ... May 26, 2016 , ... There are many ways to cook ... Council (NHDSC) suggests that Americans prefer their dogs straight off the grill. Of the ... is their favorite way to cook a hot dog, far outpacing other cooking methods ...
(Date:5/26/2016)... Atlanta, Georgia (PRWEB) , ... May 26, 2016 ... ... a certificate in intellectual property (IP) to its specialty academic programs. , Answering ... joins the college’s existing certificate programs in health law, and environmental and land ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac ... significant negative impact on long-term patient survival, reports a team of UPMC researchers ... this week in the Journal of Thoracic and Cardiovascular Surgery, provide critical information ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June 4, 2016, ... public. , Dr. Maisel, founder of Retina Group of New York , ...
(Date:5/26/2016)... Indianapolis, Indiana (PRWEB) , ... May 26, 2016 ... ... national provider of healthcare supply chain solutions, today announced the organization has earned ... management meets international standards and is compliant with all rules and policies associated ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 26, 2016 According to a new ... Market - U.S. Industry Analysis, Size, Share, Growth, Trends, and ... the U.S. was valued at US$ 5.89 Bn in 2014 ... from 2015 to 2023 to reach US$ 7.99 Bn in ... and emerging needle free drug delivery devices and the market ...
(Date:5/25/2016)... FDA 510(k) clearance covers Confocal Miniprobes ... and surgical applications Mauna Kea Technologies ... multidisciplinary confocal laser endomicroscopy (CLE) platform, today announced ... the 12 th 510(k) clearance from United ... FDA clearance covers Confocal Miniprobes indicated for use ...
(Date:5/25/2016)... YORK , May 25, 2016  According to ... reached $381 billion in 2015.  Though these are ... plenty of opportunity for success for companies that ... in search of new growth prospects medical device ... on research and development (R&D) than do companies ...
Breaking Medicine Technology: