Navigation Links
Grapefruit Compound Inhibits Hepatitis C Virus
Date:5/6/2008

Flavonoid called naringenin silences infection pathway, hints of new disease treatments

TUESDAY, May 6 (HealthDay News) -- The grapefruit flavonoid naringenin inhibits the secretion of Hepatitis C virus (HCV) in infected cells and could offer a new approach for treating the disease, according to a Harvard Medical School study.

About 3 percent of the global population is infected with HCV, which can lead to cirrhosis and liver cancer. The current standard therapy of interferon and ribavirin is only effective in about 50 percent of cases and can cause major side effects, according to background information in the study.

Recent research suggests that HVC may be "hitching a ride" along the lipoprotein life cycle, and that compounds and dietary supplements that influence lipoprotein metabolism may also affect HCV.

In this new study, researchers demonstrated that HCV is actively secreted by infected cells while bound to a very low-density lipoprotein.

"Silencing apolipoprotein B (Apo-B) mRNA in infected cells causes a 70 percent reduction in the secretion of both ApoB-100 and HCV. This ApoB-dependent HCV secretion pathway suggests a novel therapeutic approach for the treatment of HCV infection," the researchers wrote.

They then tested the grapefruit flavonoid naringenin and found it reduced HCV secretion in infected cells by 80 percent.

"The concept of supplementing HCV patients' diets with naringenin is appealing," the researchers wrote. But they noted the intestinal wall doesn't absorb naringenin well, which means therapeutic doses of the flavonoid would have to be given by injection or combined with other compounds to boost its absorption by the intestines.

The researchers also noted that naringenin and several other compounds in grapefruit have significant drug-drug interactions.

"Future studies would focus on long-term ability of naringenin and perhaps other citrus f
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Grapefruit compound may help combat hepatitis C infection
2. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
3. Sugary Sodas High in Diabetes-Linked Compound
4. Red wine compound shown to prevent prostate cancer
5. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
6. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
7. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
8. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
9. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
10. Cannabis Compound May Stop Metastatic Breast Cancer
11. Prostate Cancer Treatments Often Compound Existing Health Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... have developed a chip capable of simulating a ... system to test the effectiveness of nanoparticles and ... a tumor-microenvironment-on-chip (T-MOC) device, will allow researchers to ... barriers that prevent the targeted delivery of therapeutic ... professor of mechanical engineering., Researchers are trying to ...
(Date:9/22/2014)... Almost three-quarters (74%) of parents are aware of ... one-quarter (28%) have used those online ratings to ... to U-M research published today in Pediatrics ... Mott Children,s Hospital National Poll on Children,s Health, ... of physicians influenced their choices in seeking healthcare ...
(Date:9/22/2014)... 22, 2014 (HealthDay News) -- Metformin, a drug commonly ... low levels of thyroid-stimulating hormone (TSH) among patients with ... researchers cautioned that low TSH levels may be associated ... link was not established in this study. Among ... there were 495 incidences of low levels of thyroid-stimulating ...
(Date:9/22/2014)... 2014 “The Race is On!” for the ... Sunday, October 12, 2014 as it moves to its new ... As the signature fundraising and awareness event for Susan G. ... Phoenix Race for the Cure provides supporters of all ages ... and even sleeping in. , “Moving the Race to ...
(Date:9/22/2014)... A study led by University of North Carolina at ... the accurate diagnosis of people who are experiencing the ... delusions that define the development of severe mental disorders ... early adulthood and affects about 1 in every 100 ... person can be a life compromised, and the burden ...
Breaking Medicine News(10 mins):Health News:New chip promising for tumor-targeting research 2Health News:Online ratings influence parents' choices of physicians for their children 2Health News:Diabetes Drug Metformin May Affect Thyroid in Some Patients 2Health News:22nd Annual Susan G. Komen Phoenix Race for the Cure® 2014 Moves to Downtown Phoenix 2Health News:22nd Annual Susan G. Komen Phoenix Race for the Cure® 2014 Moves to Downtown Phoenix 3Health News:Blood test may help determine who is at risk for psychosis 2
... , , PANAMA CITY, Fla., ... hospital, diligence of staff washing their hands when moving from patient ... The Joint Commission , handwashing failures contribute to ... and cost U.S. hospitals $4 billion to $29 billion annually to ...
... , , MINNEAPOLIS, ... officers, introduced new Board Members and thanked outgoing members for their ... General Counsel, Ltd., was elected as the new Board Chair. The ... , David Fisher, Board ...
... , SAN DIEGO, Sept. 16 ... device company, today announced that its application for premarket approval (PMA) ... approved by the Food and Drug Administration. The Company can now ... , Jim Hitchin, SpectraScience,s, CEO said, "We are pleased ...
... ... supplements at 9th Annual Conference on Protein Expression in Animal Cells (PEACe) in Jackson Hole, ... Fort ... well defined and regulatory friendly cell culture media supplements at the 9th Annual PEACe conference ...
... 16 Prime Staffing, a premier staffing services has achieved ... from The Joint Commission. , , Prime ... national standards addressing how staffing firms determine the qualifications and ... how they monitor staff,s performance. , , ...
... , LONDON, Sept. 16 McGraw-Hill Medical won ... Medical Book Competition awards ceremony, including two category first prize awards ... coveted award went to the ground-breaking Robotic Surgery: Theory and ... , , Speaking about the award, Dr Vivienne ...
Cached Medicine News:Health News:Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300% 2Health News:Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300% 3Health News:Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300% 4Health News:ClearWay Minnesota(SM) Board Approves New Officers 2Health News:SpectraScience Receives FDA Approval for Enhancements to WavSTAT(R) Optical Biopsy System 2Health News:InVitria Cell Culture Product Line to Headline PEACe 2Health News:Prime Staffing Awarded Certification from The Joint Commission 2Health News:McGraw-Hill Medical Wins 2009 BMA Medical Book of the Year Award 2
(Date:9/22/2014)... DIEGO , Sept. 22, 2014  Aethlon ... targeted therapeutic devices to address infectious disease, cancer ... Defense Advanced Research Projects Agency (DARPA) has informed ... option to proceed with year four of a ... Aethlon on September 30, 2011 under DARPA,s Dialysis-Like ...
(Date:9/22/2014)... Inc. (NYSE MKT: CUR) announced that Jonathan D. ... long-term follow up data on the Phase I trial ... of amyotrophic lateral sclerosis (ALS or Lou Gehrig,s ... Symposium on ALS of the Foundation Andre-Delambre, in ... not open to the public, covered data up to ...
(Date:9/22/2014)... CENTER VALLEY, Pa. , Sept. 22, 2014 ... and delivering innovative solutions for medical and surgical ... has reached a deal with Munich ... distributor of Kick ® Navigation. This agreement ... maintain distribution for cross-disciplinary U.S. sales and all ...
Breaking Medicine Technology:Aethlon Medical Receives Notice of DARPA Contract Renewal 2Aethlon Medical Receives Notice of DARPA Contract Renewal 3Aethlon Medical Receives Notice of DARPA Contract Renewal 4Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 3Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 4Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 2Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 3Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 4
... N.J. , May 19 ... CardioTec, the first and only conference dedicated to addressing ... event, sponsored by Medical Product Outsourcing magazine, ... issues through a specialized agenda and extraordinary lineup of ...
... May 18 Thoratec Corporation (Nasdaq: ... support therapies to save, support and restore failing hearts, ... early termination of the waiting period under the Hart-Scott-Rodino ... previously announced sale of International Technidyne Corporation (ITC) to ...
Cached Medicine Technology:Medical Product Outsourcing Magazine Announces the First Annual CardioTec Conference 2Medical Product Outsourcing Magazine Announces the First Annual CardioTec Conference 3Thoratec Announces Early Termination of HSR Waiting Period for the Sale of ITC to Danaher Corporation 2
... with concave seats and large backrests with ... backrests, armrests, and casters and glides. • ... in a variety of environments including: industry, ... care and office. • With reinforced nylon ...
... with concave seats and large backrests with ... backrests, armrests, and casters and glides. • ... in a variety of environments including: industry, ... care and office. • With reinforced nylon ...
... concave seats and large backrests with lumbar ... armrests, and casters and glides. • Choose ... a variety of environments including: industry, education, ... and office. • With reinforced nylon base ...
... chairs with concave seats and large backrests ... seats, backrests, armrests, and casters and glides. ... performance in a variety of environments including: ... health care and office. • With cast ...
Medicine Products: