Navigation Links
Grape seed promise in fight against bowel cancer
Date:2/14/2014

University of Adelaide research has shown for the first time that grape seed can aid the effectiveness of chemotherapy in killing colon cancer cells as well as reducing the chemotherapy's side effects.

Published in the prestigious journal PLOS ONE, the researchers say that combining grape seed extracts with chemotherapy has potential as a new approach for bowel cancer treatment to both reduce intestinal damage commonly caused by cancer chemotherapy and to enhance its effect.

Lead author Dr Amy Cheah says there is a growing body of evidence about the antioxidant health benefits of grape seed tannins or polyphenols as anti-inflammatory agents and, more recently, for their anti-cancer properties.

"This is the first study showing that grape seed can enhance the potency of one of the major chemotherapy drugs in its action against colon cancer cells," says Dr Cheah, researcher in the School of Agriculture, Food and Wine.

"Our research also showed that in laboratory studies grape seed taken orally significantly reduced inflammation and tissue damage caused by chemotherapy in the small intestine, and had no harmful effects on non-cancerous cells. Unlike chemotherapy, grape seed appears to selectively act on cancer cells and leave healthy cells almost unaffected."

The researchers used commercially available grape seed extract, a by-product of winemaking. Tannins extracted from the grape seed were freeze-dried and powdered. The extract was tested in laboratory studies using colon cancer cells grown in culture.

The research showed grape seed extract:

  • showed no side effects on the healthy intestine at concentrations of up to 1000mg/kg;
  • significantly decreased intestinal damage compared to the chemotherapy control;
  • decreased chemotherapy-induced inflammation by up to 55%
  • increased growth-inhibitory effects of chemotherapy on colon cancer cells in culture by 26%

"Our experimental studies have shown that grape seed extract reduced chemotherapy-induced inflammation and damage and helped protect healthy cells in the gastrointestinal tract," says Dr Cheah. "While this effect is very promising, we were initially concerned that grape seed could reduce the effectiveness of the chemotherapy."

"In contrast, we found that grape seed extract not only aided the ability of chemotherapy to kill cancer cells, but was also more potent than the chemotherapy we tested at one concentration."

Co-author and project leader Professor Gordon Howarth says: "Grape seed is showing great potential as an anti-inflammatory treatment for a range of bowel diseases and now as a possible anti-cancer treatment. These first anti-cancer results are from cell culture and the next step will be to investigate more widely."

Fellow co-author and joint lead researcher Dr Sue Bastian, Senior Lecturer in Oenology, says: "These findings could be a boost to the wine grape industry as it value adds to what is essentially a by-product of the winemaking process."


'/>"/>

Contact: Dr. Amy Cheah
ker.cheah@adelaide.edu.au
61-433-910-099
University of Adelaide
Source:Eurekalert

Related medicine news :

1. Biosynthetic grape-derived compound prevents progression of Alzheimers disease in mice
2. Grapefruit Juice May Give Boost to Cancer Treatment: Study
3. More New Drugs a Bad Fit With Grapefruit, Study Finds
4. Grape News: Global Wine Manufacturing Industry Market Research Report from IBISWorld has Been Updated
5. As colorectal cancer gets more aggressive, treatment with grape seed extract is even more effective
6. Westbridge Agricultural Products Announces that Botector® has been EPA Approved as an Organic Biopesticide to Prevent Gray Mold in Grapes
7. Grape seed and skin extract - a weapon in the fight against kidney disease caused by high-fat diets
8. New Study Results Suggest that Grape Seed Extract, Like that Found in Weight Loss Supplement Prescopodene, May Help Fight Kidney Disease
9. UofL scientists uncover how grapefruits provide a secret weapon in medical drug delivery
10. Active component of grape seed extract effective against cancer cells
11. Early Study Finds Some Promise for Lung Cancer Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... , ... Lori R. Somekh, founder of the Law Office of Somekh ... law and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up ... network with elder law attorneys nationwide,” said Somekh. , ElderCounsel was ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that ... insurance companies have a waiver for care if the client has a cognitive impairment ... family pays for care, is often waived, so the benefits from their insurance start ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
Breaking Medicine Technology: