Navigation Links
Grant to study if early BPA exposure leads to late prostate cancer
Date:2/20/2008

Does exposure of baby boys -- in utero or in infancy -- to bisphenol A, a man-made chemical which mimics natural estrogens, predispose them to prostate cancer later in life?

A five-year, $2.6 million grant to a University of Illinois at Chicago researcher and her colleague aims to answer this question by shedding light on the mechanism by which it may occur.

Gail Prins, professor of urology at the UIC College of Medicine and lead investigator on the grant, and her colleague, Shuk-Mei Ho, professor and chair of environmental health at the University of Cincinnati, established in earlier studies in animals that perinatal exposure to BPA at very low doses results in increased sensitivity to estrogen as the male animal ages and an increased risk of developing prostate cancer.

Demonstrating a similar link in humans in an epidemiological study is difficult because of the small dosages and long lag time between exposure and effect. With the new grant, from the National Institute of Environmental Health Sciences, Prins and Ho will attempt to unravel the genetic mechanism by which the dose-response effect in animals is thought to occur.

Scientists think that sensitization to estrogen due to a much earlier exposure to an estrogen-like compound is an "epigenetic" phenomenon -- a heritable change in gene function that occurs without a change in the DNA sequence, as in mutation.

In this model, the early environment of the fetus causes chemical changes in DNA, called imprinting, which may cause later changes in gene expression. These epigenetic changes, which result in increased or decreased expression of a gene -- or changes in the type of tissues in which the gene is expressed -- can have profound affects on the development of an organism, Prins said. And there is increasing evidence that these changes may be implicated in the origin of a number of adult diseases, like prostate cancer.

"We hypothesize that early 'imprinting' of the prostate gland by exposure to small doses of BPA is the result of specific modifications which permanently affect gene expression in the gland," Prins said.

"As men age, they produce less testosterone and relatively more estrogen. Our work with animals has shown that exposure of the 'BPA-imprinted' prostate gland to this more estrogen-rich environment is the key to the heightened risk of developing cancer."

BPA is a key chemical in the production of polycarbonate plastic and epoxy resins and is found in products ranging from baby bottles to tin can linings. BPA may break down and leach into food or beverages when it is heated. More than a billion pounds of BPA is produced in the United States each year. The U.S. Centers for Disease Control and Prevention has found BPA in 92 percent of Americans age six or older.

The new study will work with both an animal model and human prostate-like structures and is designed to characterize the dose-response and the period of susceptibility in the developing male, to determine which genes are modified and turned on or off as a result. The researchers also plan to test directly whether the epigenetically modified genes play an active role in the later development of cancer of the prostate gland.

"It's our hope that the findings of this study will serve as a model for human exposures to prevalent environmental hormonal disruptors with suspected carcinogenic potential," said Prins.

The study may also lead to improved methods of screening men who may already be at risk, Prins said.

"In addition to increasing our understanding of how BPA affects these changes on a molecular level, identification of the specific gene modifications caused by early exposure to BPA may provide us with biomarkers for identifying men at higher risk for prostate cancer as a result of environmental exposures," said Prins.


'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Pennsylvania Department of Public Welfare Announces Grant Opportunity for Regional Autism Centers
2. Alzheimers Foundation Offers Grant for Innovative Service
3. Centene Foundation for Quality Healthcare Awards Grant to Texas Parent to Parent
4. Brandeis researcher awarded grant to investigate memory and aging
5. Elsevier Foundation announces grants for innovative libraries and new scholars
6. Elsevier Foundation Announces Grants for Innovative Libraries and New Scholars
7. Kaiser Permanente Approves $29 Million in Community Benefit Grants
8. Lisa Beth Gerstman Foundation Awarded CVS/pharmacy Community Grant
9. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
10. Isis Announces Approximately $2.8 Million in Government Grants and Contracts Awarded to its Ibis Subsidiary to Advance Ibis Pathogen Identification Technology
11. Carringtons DelSite Drug Delivery Technology Granted Patent From Eurasian Patent Office
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet is proud to announce ... covers the innovative treatments, therapeutic technologies, and revolutionized nutrition that are helping patients ... life 6 years in the last 3 decades,” says Dr. Valentine Fuster, a ...
(Date:12/2/2016)... ... 02, 2016 , ... Universal Medical Systems, Inc. (UMS) the ... company to offer robotic imaging to veterinary medicine is sponsoring the appearance of ... the American Association of Equine Practitioners 62nd Annual Convention from December 4-6, 2016 ...
(Date:12/2/2016)... ... December 02, 2016 , ... Yisrayl Hawkins, at The House of Yahweh in ... fits into Bible Prophecy. Yisrayl says this generation, known as the Last Generation, started ... how the details line up exactly with Bible Prophecy – a protected way for ...
(Date:12/2/2016)... ... 02, 2016 , ... On November 24th, 2016, Thanksgiving morning, ... different sites throughout Miami-Dade and Broward counties. This is the largest meal delivery ... Thanksgiving morning by putting together individual meals via assembly lines and passing them ...
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! ... each from the National Family Partnership and the Drug Enforcement Administration as part of ... homes and the 10 winning schools who decorated their campuses with this year’s Red ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2, 2016 CVS Health Corporation (NYSE: ... in New York City on Thursday, December 15, 2016, beginning at 8:00 a.m. ... will provide an in-depth review of the company,s strategies ... company will also discuss 2017 earnings guidance during the ... the event will be broadcast simultaneously on the Investor ...
(Date:12/2/2016)... 2016 Lianluo Smart Limited (Nasdaq: ... which develops, markets and sells medical devices and ... and international markets, recently attended the ... New Progress Forum, co-hosted by the Institute of ... , Guangdong Provincial People,s Hospital and Cardiology Department ...
(Date:12/2/2016)... -- On Thursday, the NASDAQ Composite ended the ... Average edged 0.36% higher, to finish at 19,191.93; and the ... based as six out of nine sectors ended the day ... following Services equities: Myriad Genetics Inc. (NASDAQ: MYGN ... Holdings Inc. (NASDAQ: INCR ), and La Quinta ...
Breaking Medicine Technology: