Navigation Links
Grant to study if early BPA exposure leads to late prostate cancer
Date:2/20/2008

Does exposure of baby boys -- in utero or in infancy -- to bisphenol A, a man-made chemical which mimics natural estrogens, predispose them to prostate cancer later in life?

A five-year, $2.6 million grant to a University of Illinois at Chicago researcher and her colleague aims to answer this question by shedding light on the mechanism by which it may occur.

Gail Prins, professor of urology at the UIC College of Medicine and lead investigator on the grant, and her colleague, Shuk-Mei Ho, professor and chair of environmental health at the University of Cincinnati, established in earlier studies in animals that perinatal exposure to BPA at very low doses results in increased sensitivity to estrogen as the male animal ages and an increased risk of developing prostate cancer.

Demonstrating a similar link in humans in an epidemiological study is difficult because of the small dosages and long lag time between exposure and effect. With the new grant, from the National Institute of Environmental Health Sciences, Prins and Ho will attempt to unravel the genetic mechanism by which the dose-response effect in animals is thought to occur.

Scientists think that sensitization to estrogen due to a much earlier exposure to an estrogen-like compound is an "epigenetic" phenomenon -- a heritable change in gene function that occurs without a change in the DNA sequence, as in mutation.

In this model, the early environment of the fetus causes chemical changes in DNA, called imprinting, which may cause later changes in gene expression. These epigenetic changes, which result in increased or decreased expression of a gene -- or changes in the type of tissues in which the gene is expressed -- can have profound affects on the development of an organism, Prins said. And there is increasing evidence that these changes may be implicated in the origin of a number of adult diseases, like prostate cancer.

"We hypothesize that early 'imprin
'/>"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pennsylvania Department of Public Welfare Announces Grant Opportunity for Regional Autism Centers
2. Alzheimers Foundation Offers Grant for Innovative Service
3. Centene Foundation for Quality Healthcare Awards Grant to Texas Parent to Parent
4. Brandeis researcher awarded grant to investigate memory and aging
5. Elsevier Foundation announces grants for innovative libraries and new scholars
6. Elsevier Foundation Announces Grants for Innovative Libraries and New Scholars
7. Kaiser Permanente Approves $29 Million in Community Benefit Grants
8. Lisa Beth Gerstman Foundation Awarded CVS/pharmacy Community Grant
9. Photo: Animal Rescue League of Boston Receives $3 Million Grant to Establish a Center for Shelter Dogs
10. Isis Announces Approximately $2.8 Million in Government Grants and Contracts Awarded to its Ibis Subsidiary to Advance Ibis Pathogen Identification Technology
11. Carringtons DelSite Drug Delivery Technology Granted Patent From Eurasian Patent Office
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... (PRWEB) July 31, 2014 Ticket Down ... at Levi’s Stadium in Santa Clara, California. Fans in the ... see some of the best club and national teams in the ... to Brazil, this has become the best time to be a ... and special events being held on American soil this year, as ...
(Date:7/31/2014)... 2014 David Kekich, anti-aging icon ... ) is thrilled that the acceptance of his ... Artificial Intelligence (AI) algorithms and then screening thousands ... acceptance. , “It took longer than ... proof is in," said Kekich. "Client acceptance is ...
(Date:7/31/2014)... July 31, 2014 Much of the liver,s metabolic ... body clock and UC Irvine researchers have now ... The study, published online today in Cell , ... metabolism and points the way to more focused drug ... obesity and diabetes. , Paolo Sassone-Corsi, UCI,s Donald Bren ...
(Date:7/31/2014)... July 31, 2014 BioProcess ... delivering cutting-edge information focused on the development ... launched its newly designed website, http://www.bioprocessintl.com ... by providing visitors specialized content under upstream ... business areas. As the site is updated ...
(Date:7/31/2014)... -- Many teens never outgrow their "growing pains," according ... for years, affecting teens, participation in sports and other ... growing pains can become chronic, the researchers cautioned. ... three young people between the ages of 12 and ... Michael Skovdal Rathleff, a physiotherapist from Aarhus University. "Seven ...
Breaking Medicine News(10 mins):Health News:Mexico vs. Chile Tickets Levi’s Stadium: Ticket Down Slashes Ticket Prices for Chile vs. Mexico at Levi’s Stadium in Santa Clara, California on September 6th 2Health News:Mexico vs. Chile Tickets Levi’s Stadium: Ticket Down Slashes Ticket Prices for Chile vs. Mexico at Levi’s Stadium in Santa Clara, California on September 6th 3Health News:MaxLife Solution™ Expands Distribution Globally for Breakthrough Anti-Inflammatory Support Supplement – InflaGene™ 2Health News:Strict genomic partitioning by biological clock separates key metabolic functions 2Health News:BioProcess International Launches New Website 2Health News:Teen 'Growing Pains' May Persist For Years 2
... University of Southern ... Angeles County Hospital, STEINBACH, Manitoba, Feb. 4 Partnered ... of Santa Monica, MCM,served as the millwork provider for the ... highly detailed work involving a large,number of custom nursing stations ...
... MCM,s Biggest Project Completed With Detailed Precision, ... a joint,venture of Pei Architects and Perkins & ... replacement hospital in Westwood, the Ronald,Reagan UCLA Medical ... Angeles,California. Featuring over 70,000 square feet of wall ...
... deficits , , MONDAY, Feb. 4 (HealthDay News) -- Eye ... during pregnancy but who don,t have the distinctive facial ... suggests. , "Eyeblink conditioning (EBC) is a Pavlovian ... such as a tone, with an unconditioned stimulus, such ...
... Renowned esthetician, Karen,Dunlap, has developed an advanced ... the number-one most nutritious and powerful food,in the ... between science and,nature, Dunlap discovered that topical application ... its benefits. Her new signature facial, the,Acai Berry ...
... Progen,Pharmaceuticals, Management Team (ASX: PGL; Nasdaq: PGLA) will ... 9.00am,Australian (Sydney time) and Monday 4 February at 5:00pm ... overview of the Cellgate, Inc.,acquisition and will be available ... refer to the relevant presentation at: http://www.progen-pharma.com , ...
... Trust for America,s,Health warns that the proposed 7 percent ... (CDC) in the president,s fiscal year 2009,budget could harm ... CDC would fall to a six year low for ... are skyrocketing, we should be,investing more to keep Americans ...
Cached Medicine News:Health News:MCM Completes LAC+USC Replacement Medical Facility Project 2Health News:Eye Blinks May ID Fetal Alcohol Exposure 2Health News:Breakthrough 'Acai Berry Anti-Aging Facial' Applies Benefits of Nature's Super-Food to the Skin 2Health News:Progen Investor Teleconference Dial In Details 2Health News:Cuts to HHS Could Leave Americans' Health in Critical Condition, TFAH Says; New Poll Shows Americans Believe Disease Prevention is Key to Reducing Healthcare Costs 2
(Date:7/31/2014)... LAWRENCEVILLE, N.J. , July 31, 2014  Celsion ... the Company will host a conference call to discuss ... EDT on Thursday, August 7, 2014. To participate in ... North America ) or 1-785-830-1924 (International/Toll) and ask ... (Conference Code: 8283269) to register ten minutes before the ...
(Date:7/31/2014)... , 31. Juli 2014 Marken ... Miami bekanntgegeben, um die wachsenden ... und Lateinamerika zu erfüllen. Die neu ausgebaute Einrichtung ... Proben und für die Zusammenlegung von Sendungen in ... zusätzliche Lagerkapazität bereitstellen.   Logo - ...
(Date:7/31/2014)... LAVAL, Quebec, July 31, 2014   , 2014 ... over the prior year , Overall organic growth was 4% ... facial injectable products; Bausch + Lomb grew 12% , ... increase of 43% , 2014 Second Quarter GAAP Operating ... , Highlights of the Second Quarter , Launched ...
Breaking Medicine Technology:Celsion Corporation to Hold Second Quarter 2014 Financial Results 2Marken erweitert regionales Logistikzentrum in Miami 2Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 2Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 3Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 4Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 5Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 6Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 7Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 8Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 9Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 10Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 11Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 12Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 13Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 14Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 15Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 16Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 17Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 18Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 19Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 20Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 21Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 22Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 23Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 24Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 25Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 26Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 27Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 28Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 29Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 30Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 31Valeant Pharmaceuticals Reports Second Quarter 2014 Financial Results 32
... June 14, 2011 /PRNewswire-iReach/ -- URINOZINC® ... (Photo:   http://photos.prnewswire.com/prnh/20110614/CG20097 ) ... available at all corporate-owned GNC Live Well stores ... 1935, GNC has more than 6,000 stores spread ...
... Watson Pharmaceuticals, Inc. (NYSE: WPI ) ... filed an Abbreviated New Drug Application (ANDA) with ... approval to market Olopatadine Hydrochloride Ophthalmic Solution USP, ... is a generic version of Alcon, Inc.,s Pataday™ ...
Cached Medicine Technology:Patented URINOZINC® Prostate Formula Now Available at GNC Stores 2Patented URINOZINC® Prostate Formula Now Available at GNC Stores 3Watson Confirms Pataday™ Patent Challenge 2Watson Confirms Pataday™ Patent Challenge 3
... The iCycler thermal cycler maximizes what ... laboratory. It features multiple sample formats, an ... direct upgradability to real-time quantitative PCR. The ... of what a thermal cycler can do ...
... small footprint, simple intuitive programming and almost ... the ideal personal cycler in the modern ... and the self-adjusting heated lid allows a ... vessels or a microplate of 5 x ...
... The system includes: Mx3005P instrument ... choice of five (5) filters. The ... I (492nm-516nm), HEX/JOE/VIC (535nm-555nm), ROX/Texas Red ... Also included: desktop computer, Mx3005P analysis ...
... The SmartCycler System is a rapid, real-time ... prepared biological samples. By automating much of ... site individually programmable, it is the fastest, ... now on the market. The SmartCycler delivers ...
Medicine Products: