Navigation Links
Grant to further childhood sarcoma therapeutic research
Date:6/26/2013

Researchers at Nationwide Children's Hospital will use a $6.3 million grant to further their study of pediatric sarcomas, a rare form of the disease that affects bone or soft tissue and accounts for 11 percent of all childhood cancers. The project, funded by the National Institutes of Health and the National Cancer Institute, will be led by Peter Houghton, PhD, director of the Center for Childhood Cancer and Blood Diseases in The Research Institute at Nationwide Children's.

"The ultimate goal of this project is to develop novel therapeutic approaches for advanced childhood sarcoma," said Dr. Houghton, who has spent more than three decades studying pediatric cancer through work designed to bring knowledge from the laboratory to the bedside.

While more than 70 percent of children with sarcoma are cured, the outcome is still poor for those with advanced or metastatic disease. Specifically, the five-year, event-free survival rates are 30 percent or less in children with advanced or metastatic Ewing sarcoma, osteosarcoma or rhabdomyosarcoma. Intensive chemo-radiotherapy has not significantly altered this outcome, making the search for effective new therapies a critical pursuit.

Each of the three sarcomas targeted by this grant has distinct characteristics requiring in-depth analysis of disease pathways and treatment opportunities.

"The projects will characterize the interrelationship of these pathways and identify combinatorial inhibitory approaches most likely to yield biologic activity in the clinical setting," said Dr. Houghton, also a faculty member at The Ohio State University College of Medicine.

Experts in sarcoma biology, cellular signaling pathways and drug development will collaborate on the grant, bringing together researchers from Nationwide Children's and The Ohio State University. Dr. Houghton is the principal investigator on the grant, and Nationwide Children's is responsible for its management. The researchers will collaborate on each of six smaller sections of the grant, sharing personnel and facilities. Each division of the grant will be overseen by a special director and team to create the best opportunity for synergy and innovation.


'/>"/>

Contact: Mary Ellen Peacock
maryellen.peacock@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. University of Cincinnati researchers win $3.7M grant from US Department of Defense
4. $9 million grant awarded to UH to study, treat learning disabilities
5. Louisiana Tech University professor earns NSF Early Career Development grant
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
8. 2 Grand Challenges Explorations grants for global health
9. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
10. LA BioMed receives Grand Challenges Explorations grant
11. UC San Diego Superfund Research Program receives $15 million grant renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... DIEGO , Sept. 22, 2017 AVACEN ... medical device is now successfully helping those with the ... Fibromyalgia diagnosed Amanda in Essex, ... dressed and washing my hair, experiencing no sleep at ... in painful spasm… I cannot recommend [the AVACEN 100] ...
(Date:9/19/2017)... LOUISVILLE, Ky. , Sept. 19, 2017   ZirMed ... and predictive analytics, today announced that it has been ranked ... the Black Book™ Rankings 2017 User Survey. ZirMed ... software solution for large hospitals and medical centers over 200 ... in Black Book,s healthcare technology user survey history. ...
(Date:9/18/2017)... 18, 2017 EpiVax, Inc. ("EpiVax") ... and immune engineering, today announced a new ... (H7N9) vaccine. ... influenza and presents a challenge for traditional ... to be effective. Using state-of-the-art bioinformatics and molecular ...
Breaking Medicine Technology: