Navigation Links
Grant initiates new stem cell research for patients suffering with corneal blindness
Date:6/21/2013

LOS ANGELES (June 21, 2013) Corneal blindness affects roughly 8 million people worldwide, and traditional treatments and surgical interventions have seen little long-term success. With a new vision for stem cell corneal transplantation, and a $1.25 million grant from the National Eye Institute, Cedars-Sinai co-investigators Alexander V. Ljubimov, PhD, FARVO, and Clive Svendsen, PhD, hope to treat previously untreatable patients suffering with corneal blindness.

"Our proposed and first-of-a-kind research deals with collecting human eye cells, reprograming them back in time to a stem cell state and then using them to create a corneal cell source for transplantation. If successful, this could result in future human clinical trials that may lead to improved vision and overall quality of life," said Ljubimov, principal investigator of the grant and director of the Eye Program at the Cedars-Sinai Regenerative Medicine Institute. "We are first experimenting with allogeneic cells from eye donors, but hope to use person's own cells in the near future."

A common cause of corneal blindness is limbal epithelial stem cell deficiency, which means that a patient's history of genetics or eye injuries results in corneal scarring, blood vessel growth, and outgrowth of conjunctiva, all of which lead to vision loss.

This stem cell therapy approach uses induced pluripotent stem cells (iPSC), which are adult cells that are genetically reprogrammed to function as embryonic stem cells. Typically, iPSC technology has used stem cells from other places in the patient's body, such as the skin, or from donor cells. However, advances in stem cell technology could make it possible for doctors to harvest stem cells from a patient's own cornea or sclera (the white of the eye) and then transplant the reprogrammed cells back into the cornea of the patient.

"If successful, this new approach may pave the way for human trials in patients affected by limbal ep
'/>"/>

Contact: Cara Lasala
cara.lasala@cshs.org
310-423-7798
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. University of Cincinnati researchers win $3.7M grant from US Department of Defense
4. $9 million grant awarded to UH to study, treat learning disabilities
5. Louisiana Tech University professor earns NSF Early Career Development grant
6. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
7. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
8. 2 Grand Challenges Explorations grants for global health
9. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
10. LA BioMed receives Grand Challenges Explorations grant
11. UC San Diego Superfund Research Program receives $15 million grant renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 Gabe’s Chemo Duck Program ... App, the first app ever created for kids with cancer. The ... phones and devices, is filled with enjoyable games to help children ... treatments. The free app helps to keep kids entertained, educated and ...
(Date:1/22/2015)... Houston, TX (PRWEB) January 22, 2015 The ... Pro Bodybuilder Ben Pakulski to increase lean muscle by up ... This has caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting ... shows that it is a step-by-step, scientific diet formula that ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, ... dresses. View website of AngelWeddingDress.com to find ... wedding dresses online for a bridal party. AngelWeddingDress offers ... for them. Its maternity wedding dresses are specially designed ...
(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of Cruz ... has treated just about every type of injury that can result ... those same twenty-plus years, the team at Doctors on Liens ... best possible doctor. With the combined breadth of experience ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2
... and adolescence can cause abnormal development of the femur ... reduced rotation and pain during movement. This may explain ... more sedentary individuals, according to Dr. Klaus Siebenrock, from ... work is published online in Springer,s journal Clinical ...
... TUESDAY, July 19 (HealthDay News) -- Older adults who keep ... their mental abilities, two new studies suggest. Both reports ... Internal Medicine , to coincide with presentations scheduled to be ... Paris. "We looked at an objective measure of physical ...
... of the University of Granada and Edimbourgh have developed ... might improve significantly chemotherapy, as it has not cause ... encapsulation of a catalyst (palladium) into microspheres, to synthesize ... avoiding any toxicity. This system captures palladium within its ...
... A group of French scientists (from the Unit of ... Research, Bobigny, France; the French Institute for Prevention and ... Cancer Institute) have published a paper in the ... guidelines for drinking and the relation of alcohol to ...
... HealthDay Reporter , MONDAY, July 18 (HealthDay News) -- ... have radically improved the life expectancy of HIV-infected patients ... that when made affordable and accessible, the same drug ... finding stems from a Canadian research team,s investigation -- ...
... French . A new study that ... of congenital hypothyroidism in the United States, and aimed at ... that the increase is entirely artifactual. CH is characterized by ... of preventable intellectual disability. The results were published in the ...
Cached Medicine News:Health News:Painful legacy of teen sports 2Health News:More Evidence That Exercise May Keep The Brain Sharp 2Health News:More Evidence That Exercise May Keep The Brain Sharp 3Health News:A new therapy without side effects could improve dramatically chemotherapy 2Health News:Are drinking guidelines adequate regarding the risk of cancer? 2Health News:Are drinking guidelines adequate regarding the risk of cancer? 3Health News: Drugs Can Bring HIV-Infected Africans Normal Life Spans 2Health News: Drugs Can Bring HIV-Infected Africans Normal Life Spans 3Health News: Drugs Can Bring HIV-Infected Africans Normal Life Spans 4Health News:No increase in commonest preventable cause of intellectual disability over 20 years 2
(Date:1/23/2015)... Jan. 23, 2015  MedScope ( www.medscope.org ), the leading ... a 2015 Connected World magazine Connected World ... (mPERS), that can be used anywhere, anytime. The nomination ... In nominating MedScope, Landon Garner , ...
(Date:1/23/2015)... and DUBLIN , Jan. 23, ... agreement with KRS Global Biotechnology, Inc. for the compounding, packaging ... compounded for shipment in the United States ... approved Outsourcing Facility capable of compounding naltrexone tablets in various ...
(Date:1/23/2015)... 2015  Pete Rose, baseball,s all-time hits leader, is the new ... Myoflex, Ducere Pharma has announced. "Pete,s a Hall ... have him on board with Myoflex," said Ducere Pharma Chief ... player who is known across all generations. The passion and ...
Breaking Medicine Technology:MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4Pete Rose bets on Myoflex to relieve aches and pains 2
... 6, 2012  PAREXEL International Corporation (NASDAQ: PRXL ... that Ramita Tandon, Global Head, Late Phase Clinical Trials ... Operations at PAREXEL will address innovative approaches to late ... ( SCOPE ), to be held February 7-9, 2012 ...
... New York, February 6, 2012 In the news ... of USD 6.8 billion in 2015, China Osteoporosis Market Will be ... 11:30 GMT, by Transparency Market Research over PR Newswire, we are ... "Market Size of USD 6.8 billion" has been changed to "Market ...
Cached Medicine Technology:PAREXEL to Address Innovative Approaches to Late Stage Development at Summit for Clinical Ops Executives 2PAREXEL to Address Innovative Approaches to Late Stage Development at Summit for Clinical Ops Executives 3PAREXEL to Address Innovative Approaches to Late Stage Development at Summit for Clinical Ops Executives 4CORRECTION - Transparency Market Research: Global Osteoporosis Market is Expected to Attain a Market Size of USD 11.4 billion in 2015, China Osteoporosis Market Will be Worth USD 2.5 Billion in 2015 2CORRECTION - Transparency Market Research: Global Osteoporosis Market is Expected to Attain a Market Size of USD 11.4 billion in 2015, China Osteoporosis Market Will be Worth USD 2.5 Billion in 2015 3CORRECTION - Transparency Market Research: Global Osteoporosis Market is Expected to Attain a Market Size of USD 11.4 billion in 2015, China Osteoporosis Market Will be Worth USD 2.5 Billion in 2015 4
... Mesh Self-Forming Plug is a mesh plug ... well as primary inguinal hernias and femoralhernias. ... defect and fills it completely. Premilene Mesh ... of the established Premilene Mesh. The plug ...
... The Celsius Control System provides ... can safely,and rapidly lower patient ... target temperature and,rewarm patients to ... System consists of an endovascular,catheter, ...
... lightsource , it maximizes use by ... from it, while the third lamp ... managed care in mind, it includes ... cables. An excellent choice for hospital ...
... the patented Orion incorporates superior optics in ... The fully adjustable headband, made of ... low on the brow, directing the spot ... clips on the headband position the cable ...
Medicine Products: