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Grant initiates new stem cell research for patients suffering with corneal blindness
Date:6/21/2013

LOS ANGELES (June 21, 2013) Corneal blindness affects roughly 8 million people worldwide, and traditional treatments and surgical interventions have seen little long-term success. With a new vision for stem cell corneal transplantation, and a $1.25 million grant from the National Eye Institute, Cedars-Sinai co-investigators Alexander V. Ljubimov, PhD, FARVO, and Clive Svendsen, PhD, hope to treat previously untreatable patients suffering with corneal blindness.

"Our proposed and first-of-a-kind research deals with collecting human eye cells, reprograming them back in time to a stem cell state and then using them to create a corneal cell source for transplantation. If successful, this could result in future human clinical trials that may lead to improved vision and overall quality of life," said Ljubimov, principal investigator of the grant and director of the Eye Program at the Cedars-Sinai Regenerative Medicine Institute. "We are first experimenting with allogeneic cells from eye donors, but hope to use person's own cells in the near future."

A common cause of corneal blindness is limbal epithelial stem cell deficiency, which means that a patient's history of genetics or eye injuries results in corneal scarring, blood vessel growth, and outgrowth of conjunctiva, all of which lead to vision loss.

This stem cell therapy approach uses induced pluripotent stem cells (iPSC), which are adult cells that are genetically reprogrammed to function as embryonic stem cells. Typically, iPSC technology has used stem cells from other places in the patient's body, such as the skin, or from donor cells. However, advances in stem cell technology could make it possible for doctors to harvest stem cells from a patient's own cornea or sclera (the white of the eye) and then transplant the reprogrammed cells back into the cornea of the patient.

"If successful, this new approach may pave the way for human trials in patients affected by limbal ep
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Contact: Cara Lasala
cara.lasala@cshs.org
310-423-7798
Cedars-Sinai Medical Center
Source:Eurekalert

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