Navigation Links
Grant helps UT Southwestern researcher study causes of preterm birth

DALLAS April 7, 2011 A UT Southwestern Medical Center gynecologist is one of five researchers nationwide selected to receive a $600,000 Burroughs Wellcome Fund grant to investigate the biological mechanisms and causes of premature birth.

Dr. Mala S. Mahendroo, associate professor of obstetrics and gynecology in the Cecil H. and Ida Green Center for Reproductive Biological Sciences, will use the support to develop a second harmonic generation imaging (SHG) endoscope to be used in vivo in animals, and eventually in women, to assess premature collagen changes that precede preterm birth.

"This grant will allow us to do molecular studies on the cervix and develop a clinical tool to identify women at risk for preterm birth," Dr. Mahendroo said.

According to medical experts, nearly 13 percent of births in the U.S. more than one-half million annually are preterm. Rates are even higher in African-American and obese populations. While a normal term delivery occurs at around 40 weeks, more than 70 percent of premature babies are born between 34 and 36 weeks gestation.

The causes of preterm labor are not fully understood. Premature babies are at increased risk for newborn health complications such as breathing problems, underdeveloped organs and even death.

"Biological research is done in small steps," said John Burris, president of the Burroughs Wellcome Fund. "It is our hope that by funding creative, innovative research, new therapies will be developed."

An independent private foundation, the Burroughs Wellcome Fund helps advance the medical sciences by supporting research and other scientific and educational activities. Its board's general strategy is to help scientists early in their careers develop as independent investigators, and to support scientists who are working in, or entering, biomedical science fields that are poised for significant advance but currently undervalued and underfunded.

Dr. Mahendroo's laboratory work focuses on the molecular processes that bring about cervical ripening and remodeling from a closed rigid structure to one that expands enough to allow the passage of a full-term baby. She and colleagues hope to understand the molecular events that regulate the change in collagen structure in order to develop therapies that prevent preterm labor.

"Changes in cervical collagen organization begin relatively early in pregnancy and are incremental and progressive," she said. "SHG imaging allows us to visualize and distinguish these microscopic collagen changes."

Dr. Mahendroo joined the UT Southwestern faculty in 2000. A Texas A&M graduate, she earned her doctorate in biochemistry and molecular biology from UT Southwestern, where she also completed a postdoctoral fellowship in molecular genetics.


Contact: Robin Russell
UT Southwestern Medical Center

Related medicine news :

1. NACDD Receives Two-Year Grant From Merck & Co., Inc. to Improve Diabetes Education
2. Kaiser Permanente Approves $170 Million in Community Benefit Grants in 2009
3. Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders
4. Perrigo Granted Summary Judgment of Non-Infringement in Mucinex(R) Case
5. US21, Inc. is Granted a Wholesale Distributor Permit from the Commonwealth of Virginia Board of Pharmacy
6. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
7. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
8. Special Olympics Georgia Receives Grant from The Home Depot Foundation
9. NIH grant will create behavioral health registry for pediatric inflammatory bowel disease
10. San Diego Unified School District Awarded Silent Hero Grant From got breakfast?(R) Foundation
11. Congressional Staff Briefing, Wed., Feb. 24 on Mental Health, Medicaid & Block Grants
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... ... center software Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term Support) ... supported Asterisk 11 LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, they also ... buy during the Black Friday and Cyber Monday massage chair sales to ... Internet high and low to find the best massage chair deals, they can see ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... Express Travel Representative. As a franchise owner, Somu now offers travelers, value and ... destination wedding packages, private cruise sales, as well as, cabin upgrades and special ...
(Date:11/26/2015)... NE (PRWEB) , ... November 26, 2015 , ... Jobs ... searched by healthcare professionals and offered by healthcare staffing agency Aureus Medical Group ... during the month of October 2015 among those searching for healthcare jobs through the ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... second medical opinion process, participated in the 61st annual Employee Benefits Conference. The ... and took place Sunday, November 8th through Wednesday, November 11th, 2015. The conference ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... november 2015 AAIPharma Services Corp./Cambridge ... investering aan van ten minste $15,8 miljoen ... het mondiale hoofdkantoor in Wilmington, ... in extra kantoorruimte en extra capaciteit voor ... behoeften van de farmaceutische en biotechnologische markten. ...
(Date:11/26/2015)... --> --> Juntendo University ... contrast weighting of MRI for patients with Multiple Sclerosis ... agreement with SyntheticMR in order to use SyMRI in clinical ... to generate multiple contrast images from a single scan and ... making it possible to both fine tune images and recreate ...
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new ... Japanese therapeutic drug monitoring market, including emerging tests, ...
Breaking Medicine Technology: