Navigation Links
Grant for brain tumor and deafness research
Date:7/27/2009

Researchers at the Peninsula Medical School have received a grant of over 39,000 from the charity Deafness Research UK, to investigate the role of brain tumours causing deafness in children and adults and the development of therapies using in vitro models.

These tumours and a variety of other tumours are caused by mutations affecting a protein called merlin, which in turn cause cancers in a range of cell types including Schwann cells in the nervous system. Schwann cells produce the sheaths that surround and insulate neurons.

Although the tumours are benign, they are frequent. They can be inherited and come in numbers. The sheer number of them can overwhelm a patient, often leading to deafness and eventually to death. Patients can suffer from 20 to 30 tumours at any one time, and the condition typically affects older children and young adults.

No therapy, other than invasive surgery aiming at a single tumour and which may not eradicate the full extent of the tumours, exists. The hereditary condition affects one in every 2,500 people worldwide. It can affect any family, regardless of past history, through gene mutation and currently there is no cure.

In some cases, pressure from the tumours affect the process of hearing leading to hearing loss or total deafness. The research will use a human acoustic neuroma in vitro model to identify how and why the tumours grow and eventually lead to hearing damage, and to test drug-based therapies designed to alleviate the problem.

The research is led by Professor Oliver Hanemann, Chair of Clinical Neurobiology at the Peninsula Medical School. He said: "We have already achieved some success in re-profiling an existing drug called sorafenib by using the human in-cell model. The re-profiled drug has a positive affect on multiple brain tumours. As a consequence, we can go straight to clinical trials and introduce therapies to patients sooner rather than later using sorafenib or simila
'/>"/>

Contact: Andrew Gould
andrew.gould@pms.ac.uk
The Peninsula College of Medicine and Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
2. UT Southwesterns obesity research receives $22 million NIH Roadmap grant
3. $21.8 Million NIH Grant for Fragile X Research
4. Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine
5. Boston University School of Medicine researcher recipient of Memory Ride Grant
6. RAND researchers offer options to improve immigrant health care quality, access
7. Pennsylvania Department of Aging Receives Grant to Improve Alzheimers Support
8. CAS Medical Systems, Inc. Awarded $2.8 Million Grant by National Institutes of Health
9. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
10. Johns Hopkins receives $100 million grant to speed research from clinic to community
11. Major grant advances UWs clinical and translational research enterprise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Aug. 20, 2014 (HealthDay News) -- Loss of brain ... explain why many seniors have trouble falling and staying ... sleep disruption can be especially severe and often results ... The investigators analyzed data from the Rush Memory ... enrolled at age 65 and are being followed until ...
(Date:8/20/2014)... Steven Reinberg HealthDay Reporter ... speed at which cancer cells grow may help doctors diagnose ... Using this measure, investigators have found that the deadliest skin ... older men with a long history of sun exposure. ... researchers discovered. Rapid cell growth -- called "high ...
(Date:8/20/2014)... 2014 The Board of Directors of ... is pleased to announce the expansion of its ... China and the surrounding region. In support of ... AIA has relocated to the firm’s office in ... planning and design and to better support regional clients. ...
(Date:8/20/2014)... is one of the most persistent and deadliest infectious ... people each year. , Scientists who study tuberculosis have ... likely spread from humans in Africa to seals and ... and transmitted it to Native people there before Europeans ... Genomes Reveal Seals as a Source of New World ...
(Date:8/20/2014)... that sprint to spawning grounds through fast-moving waters may ... British Columbia scientists. , When salmon encounter turbulent, fast-moving ... dams they must move upstream using a behaviour ... for humans. , "Days after sockeye passed through extremely ... a short distance from their spawning grounds," said Nicholas ...
Breaking Medicine News(10 mins):Health News:Seniors' Sleep Woes May Be Linked to Loss of Brain Cells 2Health News:High-Risk Melanomas Often on Head or Neck, Study Finds 2Health News:High-Risk Melanomas Often on Head or Neck, Study Finds 3Health News:Perkins Eastman Expands Presence in China 2Health News:Perkins Eastman Expands Presence in China 3Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Salmon forced to 'sprint' less likely to survive migration 2
... Nov. 11 Health care costs and heightened public ... That,s according to a recent MamboTrack(TM) study by ... and organic product marketing and promotions, which surveyed the organic ... get an outlook for the coming year. , Nine ...
... ... has teamed up with world renowned high altitude mountaineer and adventure athlete Will Cross to ... , ... November 11, 2009 -- Tender Corp ., a leading manufacturer of over-the-counter topical cream ...
... Security Division of EMC (NYSE: EMC ) announced ... services company, has almost quadrupled its deployment of the ... network access in order to help guarantee business continuity. ... of employees including members of upper management. It decided ...
... OrthoAccel Technologies, Inc., developers of the ... to enhance orthodontics, announced that its application to market ... Australia,s Therapeutic Goods Administration (TGA) . ... in Australia. , (Photo: http://www.newscom.com/cgi-bin/prnh/20091111/DA09142 ...
... The New York Conference on Well-Being ... bringing together an international group of leading psychiatrists, ... and the International Network of Person-Centered Medicine organized ... and health promotion in medicine and psychiatry. Participants ...
... radiology treatment that uses targeted image-guided drug delivery ... clots in the lungssaves lives and should be ... embolism, note researchers in the November Journal ... "Modern catheter-directed therapy for acute pulmonary embolism saves ...
Cached Medicine News:Health News:Natural and Organic Consumers Focus on Health and Wellness Amidst Public Health Concerns 2Health News:High Altitude Mountaineer Will Cross Joins Tender's HealthiFeet Team to Raise Awareness On Foot Care for People Battling Diabetes 2Health News:High Altitude Mountaineer Will Cross Joins Tender's HealthiFeet Team to Raise Awareness On Foot Care for People Battling Diabetes 3Health News:High Altitude Mountaineer Will Cross Joins Tender's HealthiFeet Team to Raise Awareness On Foot Care for People Battling Diabetes 4Health News:Swiss Environmental Company Taps RSA to Ensure Business Continuity in the Event of Global H1N1 Pandemic 2Health News:Swiss Environmental Company Taps RSA to Ensure Business Continuity in the Event of Global H1N1 Pandemic 3Health News:AcceleDent System From OrthoAccel Technologies, Inc. Secures Medical Device Regulatory Clearance to Market in Australia 2Health News:AcceleDent System From OrthoAccel Technologies, Inc. Secures Medical Device Regulatory Clearance to Market in Australia 3Health News:Conference of International Experts Calls for a Focus on Well-Being and The Person in Health 2Health News:Conference of International Experts Calls for a Focus on Well-Being and The Person in Health 3Health News:When seconds count: Interventional radiology treatment for pulmonary embolism saves lives 2Health News:When seconds count: Interventional radiology treatment for pulmonary embolism saves lives 3
(Date:8/20/2014)... 2014  The National Association of Drug Diversion ... by the real-time, pseudoephedrine (PSE) blocking system in ... Exchange (NPLEx), automatically blocks unlawful PSE sales and ... and make arrests. Data released by NPLEx shows ... blocked the sale of more than 23,478 boxes of ...
(Date:8/20/2014)... 2014  The National Association of Drug Diversion ... by the real-time, pseudoephedrine (PSE) blocking system in ... Exchange (NPLEx), automatically blocks unlawful pseudoephedrine sales and ... and make arrests. Data released by NPLEx shows ... blocked the sale of more than 32,890 boxes of ...
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com ... available in its catalogue: The Impact ... Industry http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html ... (H.R. 3590) is complex legislation that affects virtually ... its provisions are beginning to take effect now. ...
Breaking Medicine Technology:Kentucky's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Michigan's Stop-Sale System Achieves Significant Results In Battle Against Meth 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6
... Pa., May 17, 2011 Inovio Pharmaceuticals, Inc. (NYSE ... development of therapeutic and preventive vaccines against cancers and ... its DNA vaccines and electroporation delivery technology at the ... & Cell Therapy to be held May 18-21 in ...
... May 16, 2011 Awarepoint Corporation , the ... for hospitals, announced today that it named Ralph Keiser ... as executive vice president of marketing and business development ... opportunities in the domestic and international RTLS markets. ...
Cached Medicine Technology:Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 2Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 3Inovio Pharmaceuticals to Present at American Society of Gene & Cell Therapy Annual Meeting May 18 - 21, 2011 4Awarepoint Expands Senior Management Team 2Awarepoint Expands Senior Management Team 3
... Agarose-HR™ High Resolution - ... from 50 to 1000 ... for sizing PCR fragments, ... by restriction enzyme digestion, ...
... for screening donors on the PK7200 Automated ... CMV antigen attached to a gelatin particle ... and specificity of the CMV assay as ... respectively. The use of a gelatin particle ...
The reading of agglutinations process in Diana Reader is by image treatment which allows great sensitivity....
... works on patented microplate agglutination technology. Its ... for donor ABO/Rh testing. PK7200 also handles ... cytomegalovirus antibody detection. The Automated Microplate System ... the proven reliability that for the past ...
Medicine Products: