Navigation Links
Grandmother's cigarette habit could be the cause of grandchild's asthma
Date:3/4/2013

LOS ANGELES (March. 4, 2013) Grandmother's cigarette smoking could be responsible for her grandchild's asthma, and the recent discovery of this multi-generational transmission of disease suggests the environmental factors experienced today could determine the health of family members for generations to come, two Los Angeles Biomedical Research Institute (LA BioMed) lead researchers write in the March edition of Review of Obstetrics & Gynecology.

The researchers, John S. Torday, PhD, and Virender K. Rehan, MD, wrote an editorial citing recent studies by Dr. Rehan that found pregnant rats given nicotine produced asthmatic pups that went on to produce their own asthmatic pups, despite the absence of nicotine exposure in the third generation.

The findings suggest nicotine can leave heritable epigenetic marks on the genome, which make future offspring more susceptible to respiratory conditions.

The researchers also cited the Children's Health Study from Southern California, which reported that grandmaternal smoking during pregnancy increases the risk of asthma in grandchildren regardless of whether the mother smoked or not.

Based on those findings, the researchers conclude that environmental factors experienced during pregnancy will affect not only the child in utero but also future generations of the same family. They say this multi-generational transmission could explain why 98% of inherited human diseases are unaccounted for by the prevailing view of genetic trait transmission, known as Mendelian genetics.

The researchers concluded that the cause of the second generation's asthma was epigenetic modification (an environmental factor causing a genetic change). Nicotine was affecting both the lung cells and the sex cells in ways that caused the lungs that developed from those cells to develop abnormally, causing asthma.

"These studies break new ground in validating and further explaining the mechanisms involved in the transmission of epigenetic human diseases," Dr. Torday said. "The transmission of the asthma to the second generation and its prevention by a specifically-targeted molecular intervention are the first unequivocal demonstrations of multi-generational transmission of an epigenetically-mediated effect on the offspring."

Dr. Rehan, who has conducted multiple studies on nicotine's effects, noted that asthma rates are growing in the U.S. and around the world. World-wide, approximately 250,000,000 women smoke daily. Twelve percent of women in the U.S. continue to smoke during pregnancy, resulting in the birth of at least 400,000 smoke-exposed infants per year in the U.S. alone

"Asthma is the most common chronic disease of childhood, resulting in a significant impact on the lives of children and driving up medical costs for all," Dr. Rehan said. "While many factors contribute to asthma, smoking during pregnancy is a well-established one and one that can be avoided. Eliminating smoking during pregnancy would significantly reduce the prevalence of childhood asthma for this generation and for future generations."


'/>"/>

Contact: Laura Mecoy
lmecoy@labiomed.org
310-546-5860
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Source:Eurekalert

Related medicine news :

1. One in Five U.S. Smokers Has Tried an E-Cigarette
2. UIC researchers to study how young adults use e-cigarettes, snus
3. Many Americans Back Nicotine Restrictions in Cigarettes: Survey
4. Pictures Speak Louder Than Words on Cigarette Labeling
5. Graphic warnings on cigarettes effective across demographic groups
6. Pricey Cigarettes, Strict Schools Help Curb Teen Smoking
7. Putting electronic cigarettes to the test
8. Heavy Smokers Cut Back the Most When Cigarette Taxes Rise: Study
9. Gruesome Cigarette Pack Images Sway Smokers, Study Finds
10. Pictures effective in warning against cigarette smoking
11. Researchers find why nicotine in cigarettes may relieve anxiety in smokers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
Breaking Medicine Technology: