Navigation Links
Got taste?
Date:12/22/2009

Waltham, MAAs anyone suffering through a head cold knows, food tastes wrong when the nose is clogged, an experience that leads many to conclude that the sense of taste operates normally only when the olfactory system is also in good working order. Evidence that the taste system influences olfactory perception, however, has been vanishingly rareuntil now. In a novel study this week in Nature Neuroscience, Brandeis researchers report just such an influence.

Neuroscientist Don Katz and colleagues discovered that if the taste cortex in rats is inactivated when a rat first smells an odor, at least a food odor, then the rat subsequently will only recognize the food associated with that odor if the taste cortex is again inactivated.

"We discovered that rats use their taste system to smell with, so when you knock out the taste cortex, even for an hour, as we did, you alter their sense of smell," explained Katz. The researchers wrote that "this is the only example of state dependency in neural circuit function of which we are aware."

Katz and his colleagues used a multi-step training process to test the interdependence of the taste and olfactory systems. In the first step, a demonstrator rat that had just eaten chow flavored with one of four spices was introduced to a subject rat, which then smelled the demonstrator rat's breath.

In the second step, the subject rat was offered two choices of chow: one dish with the same flavor previously consumed by the demonstrator rat and another with a different flavor. The subject rat reliably preferred the food that it had previously smelled on the demonstrator rat's breath the day before. The researchers concluded that the social "smell test" of rat's breath is a good enough cue for rats to prefer one food over another.

At the outset they predicted that the rat's sense of smell would not be affected by changes in its taste system. "But we were wrong," said Katz. "Most surprisingly, the rats whose taste cortex was knocked out again the next day preferred the chow that they had experienced in an altered state, with no taste cortex.

"We discovered in this experiment that the sensory systems don't work in isolation from each other, said Katz. "One part of the cortex takes direct input from the nose, and one part from the tongue, and while it's convenient to think that the nose and taste receptors operate independently, they don't."

Katz actually tested two possible explanations for the basic result: First, taste cortex might be an integral component of how the animal processes smells. Alternatively, it might be that taste cortex changes, or modulates, olfactory circuits rather than coding them, fundamentally changing perception of smell at that point in time. Such "incorrect" memories of smell apparently last across at least a week of the rats' lives, and perhaps forever.

The Katz lab is now using brain recordings to pinpoint which parts of the olfactory system are affected when taste cortex is silenced, and to characterize the nature of the interaction between the taste and smell systems during feeding.

"I am hoping that ultimately this discovery will help drive us to an entirely different approach to brain function," said Katz. "It doesn't make sense to probe one system separately from the other. Just like in a chorus, you can't appreciate the fullness of the music if you hear only the bass or the tenor in isolation."


'/>"/>

Contact: Laura Gardner
gardner@brandeis.edu
781-736-4204
Brandeis University
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... , ... February 08, 2016 , ... ... in Houma, LA, celebrates the beginning of a new charity campaign. As part ... Court Appointed Special Advocates (CASA). In the belief that children deserve a voice, ...
(Date:2/8/2016)... PISCATAWAY, N.J. (PRWEB) , ... February 08, 2016 ... ... of protective footwear and clothing, announced expansion into Canada to provide its range ... has opened a sales office in Quebec City that will provide bilingual customer ...
(Date:2/8/2016)... Atlanta, GA (PRWEB) , ... ... ... information technology and security executive networking and relationship-marketing firm, announced today that ... the 2016 Information Security Executive® (ISE®) West Awards. , Awards include ...
(Date:2/8/2016)... CA (PRWEB) , ... February 08, 2016 , ... ... showing greater than 50% lower incidence rate of type 2 diabetes in the ... averages. ”It is time to make a change in public health,” states Carole ...
(Date:2/8/2016)... ... February 08, 2016 , ... The schedule is now online ... The AutismOne 2016 Conference, which is being held May 25-29 at the Loews Chicago ... about helpful interventions and causes of chronic illness in children. , Very recent articles ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  As people age, ... The multitude of recommended screenings and tests that are ... a priority. However, for the majority of aging individuals, ... health planning. For the 37.5 million American adults who ... the present to make hearing health a 2016 healthy ...
(Date:2/5/2016)... , Feb. 5, 2016  Aralez Pharmaceuticals Inc. ("Aralez") ... POZEN Inc. ("POZEN") and Tribute Pharmaceuticals Canada Inc. ("Tribute") following ... shareholders of Tribute. The combined company will operate under ... with operations in Canada , ... States . Under the terms of the Agreement ...
(Date:2/5/2016)... , Feb. 5, 2016 Aethlon Medical, Inc. (Nasdaq: ... Chairman and CEO, will be presenting at Source Capital Group,s ... York, NY at 2:15 p.m. ET on Wednesday, ... Immunotherapy Panel discussion taking place at 3:15 p.m. ET. ... approximately one hour after the conclusion of the live event. ...
Breaking Medicine Technology: