Navigation Links
'Good cholesterol' nanoparticles seek and destroy cancer cells
Date:4/1/2011

HOUSTON - High-density lipoprotein's hauls excess cholesterol to the liver for disposal, but new research suggests "good cholesterol" can also act as a special delivery vehicle of destruction for cancer.

Synthetic HDL nanoparticles loaded with small interfering RNA to silence cancer-promoting genes selectively shrunk or destroyed ovarian cancer tumors in mice, a research team led by scientists from The University of Texas MD Anderson Cancer Center and the University of North Texas Health Science Center reports in the April edition of Neoplasia.

"RNA interference has great therapeutic potential but delivering it to cancer cells has been problematic," said Anil Sood, M.D., the study's senior author and MD Anderson's director of Ovarian Cancer Research and co-director of the Center for RNA Interference and Non-Coding RNA at MD Anderson. "Combining siRNA with HDL provides an efficient way to get these molecules to their targets. This study has several important implications in the ability to fight certain cancers."

Sood and Andras Lacko, Ph.D., professor of Molecular Biology and Immunology at UNT Health Science Center, jointly developed the nanoparticles, which build on Lacko's original insight about HDL's potential for cancer drug delivery.

The next step is to prepare for human clinical trials, the two scientists said. "If we can knock out 70, 80 or 90 percent of tumors without drug accumulation in normal tissues in mice, it is likely that many cancer patients could benefit from this new type of treatment in the long run," Lacko said.

Only cancer and liver cells express HDL receptor

Previous studies have shown that cancer cells attract and scavenge HDL by producing high levels of its receptor, SR-B1. As cancer cells take in HDL, they grow and proliferate. The only other site in the body that makes SR-B1 receptor is the liver. This selectivity for cancer cells protects normal, healthy cells from side
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Laughter Not Only Feels Good, Its Good for the Heart
2. Good vibrations?
3. Being in a good mood may lead to poor memory
4. Social Media Has Good and Bad Effects on Kids: Experts
5. Good news! Hope makes headlines
6. Good news for meat lovers: Most ready-to-eat meat products contain very few cancerous compounds
7. Study: Multi-tasking on the street not a good idea for older people
8. Think You Have a Perfect Partner? Thats a Good Sign
9. Good Cholesterol May Cut Colon Cancer Risk
10. Optimism Is Good for Your Heart
11. Free radicals may be good for you
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Good cholesterol' nanoparticles seek and destroy cancer cells
(Date:5/18/2013)... swallow high-powered magnets often need surgery and other invasive ... study. The researchers, from the Louisiana State University ... 79 percent of children who swallowed very strong "neodymium ... which a tube containing a camera is inserted into ... can be treated through observation or by pumping the ...
(Date:5/18/2013)... MOOSGO.COM published an original art book for iPad ... group of artists who share their creations based on the ... Exclusively for iPad . , This work gathers ... that reflect the signature idiosyncrasy and passion of tango. Such ... Store and it includes a free trailer of the ...
(Date:5/18/2013)... 2013) There are significant cost and risk ... diagnose or treat gastrointestinal problems, according to research ... A study by New York Presbyterian Hospital and ... may substantially reduce the cost and risk of ... believed to affect nearly 25 percent of adults, ...
(Date:5/18/2013)... In a May 14, 2013 article entitled “Angelina ... Cancer Gene,” Fox News reported the movie star had ... carried a gene that doctors estimated gave her an ... percent risk of ovarian cancer (go to: goo.gl/5JHBP). Ms. ... with a blog post entitled “A Patient’s Journey: Angelina ...
(Date:5/18/2013)... Orlando, FL (May 18, 2013) A ground-breaking ... colorectal care, according to research presented today at ... optimizing the minimal withdrawal time for colonoscopies and ... , During colonoscopy, doctors use a device called ... test for colorectal cancer allows a doctor to ...
Breaking Medicine News(10 mins):Health News:Swallowing Magnets Can Be Fatal for Children 2Health News:New Art Book for iPad: Tango Art 2Health News:New research identifies practice changes to improve value and quality of GI procedures 2Health News:Angelina Jolie – Scarless Breast Augmentation Surgery 2Health News:New colonoscope provides ground-breaking view of colon 2Health News:New colonoscope provides ground-breaking view of colon 3Health News:New colonoscope provides ground-breaking view of colon 4
... American Speech-Language-Hearing Association (ASHA) has announced plans to award ... of the Association for her pioneering research and academic ... Chair in Communication Disorders in the School of Behavioral ... research in the Callier Center for Communication Disorders. In ...
... INDIANAPOLIS Technologies for rapid detection of bacterial ... supply. Researchers from the School of ... the Bindley Bioscience Center at Purdue University have ... classification of harmful bacteria in food. The investigators ...
... in the Oct. 15 issue of the Journal of ... a much higher prevalence and risk of restless legs syndrome ... may improve sleep and quality of life in people with ... syndrome was about 10 times higher in the fibromyalgia group ...
... precursors of all the tissues in our body, can ... cancer. Now research from Rockefeller University shows that having ... for too long, can increase the odds of developing ... death in precursor cells for blood, or hematopoietic stem ...
... known as beta blockers have been proven to increase patients, ... workload and oxygen demand on the heart. In a breakthrough ... Medicine cardiologist Jeffrey J. Goldberger found the majority of patients ... drugs, which can put their recovery from heart attacks and ...
... HealthDay Reporter , THURSDAY, Oct. 14 (HealthDay News) ... follows all the recommended colon cancer screening guidelines, a new ... for some tests, while the remaining 40 percent don,t follow ... "There,s more work to be done to understand how to ...
Cached Medicine News:Health News:Award to honor pivotal career in speech research 2Health News:Award to honor pivotal career in speech research 3Health News:Eat safer: Novel approach detects unknown food pathogens 2Health News:Study finds a high rate of restless legs syndrome in adults with fibromyalgia 2Health News:Gene identified that prevents stem cells from turning cancerous 2Health News:Gene identified that prevents stem cells from turning cancerous 3Health News:Low beta blocker dose can put patients at risk for subsequent heart attacks 2Health News:Most Doctors Don't Follow Colon Cancer Screening Guidelines 2Health News:Most Doctors Don't Follow Colon Cancer Screening Guidelines 3
(Date:5/16/2013)... and SYDNEY , May 16, 2013 /PRNewswire/ ... HIN), a leading innovator of less invasive, miniaturized circulatory support ... today announced that CEO Doug Godshall ... Conference at 11:00 a.m. EDT on Monday, May 20, 2013.  ... Sheraton New York Hotel. A live webcast of ...
(Date:5/16/2013)... REDWOOD CITY, Calif. , May 16, 2013 ... pharmaceutical company focused on the development and commercialization of innovative ... announced that Richard King , President and ... Healthcare Conference at the Sheraton New York Hotel in ... for Wednesday, May 22, 2013 at 9:30 a.m. ET/6:30 a.m. ...
(Date:5/16/2013)... Developers of a pill bottle that wirelessly transmits data, measures ... winners in the Healthcare Innovation World Cup , the ... by HITLAB . Winning team members ... and Mike Morena of Team ... will receive $50,000 in prize money. They earned the ...
Breaking Medicine Technology:HeartWare Presentation At The 2013 UBS Global Healthcare Conference To Be Webcast 2AcelRx Pharmaceuticals to Present at the UBS Global Healthcare Conference 2AcelRx Pharmaceuticals to Present at the UBS Global Healthcare Conference 3Wireless Pill Bottle Wins Healthcare Innovation World Cup 2Wireless Pill Bottle Wins Healthcare Innovation World Cup 3Wireless Pill Bottle Wins Healthcare Innovation World Cup 4Wireless Pill Bottle Wins Healthcare Innovation World Cup 5
... WASHINGTON, Sept. 27, 2011 Nearly three quarters ... comprised of products imported from developed markets, but the next ... developed specifically for the unique needs of the India market, ... PRTM Management Consulting , which were presented today at AdvaMed ...
... 2011 Critical information that dietary supplement manufacturers ... Food & Drug Administration,s (FDA) good manufacturing practices ... paper available at http://www.microtestlabs.com/dietarypaper . ... A New Paradigm for Manufacturers ," provides how-to ...
Cached Medicine Technology:Made in India, for India, is Next Wave of Growth for Region's Medical Technology Sector 2Made in India, for India, is Next Wave of Growth for Region's Medical Technology Sector 3New White Paper for Dietary Supplement Manufacturers Provides How-to for New FDA Compliance Paradigm 2New White Paper for Dietary Supplement Manufacturers Provides How-to for New FDA Compliance Paradigm 3
PT wires combine the enhanced durability of a linear elastic nitinol distal core and a highly resilient polymer tip. This provides excellent access in difficult cases involving severe tortuosity, tig...
9mm Gently Curved Jaws, WIth Lock, in Titanium....
5mm Gently Curved Wing Span, With Centering Pin, Low Profile; in stainless steel....
Retractable, straight double Lancet Blade, 15 Degree Angle , available in variations; Titanium handle...
Medicine Products: