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Golimumab Eases Rheumatoid Arthritis Symptoms
Date:6/11/2008

pital in Toronto, said in prepared statement. "Since some patients do not respond adequately to methotrexate alone, this combination therapy could prove to be a highly valuable treatment option based on these results."

In the second study, rheumatoid arthritis patients who had never taken methotrexate were treated with that drug and either 50 milligrams or 100 milligrams of golimumab. These patients also experienced a lessening of the signs and symptoms of arthritis as well as in disease activity, with 38 percent of those receiving the two drugs experiencing a 50 percent drop in signs and symptoms of RA after 24 weeks. Just 29 percent of those receiving a placebo plus methotrexate experienced a similar improvement in their condition.

Thirty-eight percent of patients receiving golimumab meet the remission standard after 24 weeks.

"These data show that treatment with golimumab induces an important depth of response, improving multiple aspects of rheumatoid arthritis and leading to significant decreases in disease activity," study investigator Dr. Roy Fleischmann, chief of the rheumatology division at St. Paul University Hospital in Dallas, said in a prepared statement. "Golimumab is a promising treatment option for multiple patient populations with this chronic and potentially debilitating inflammatory disease."

More information

The U.S. National Library of Medicine has more about rheumatoid arthritis.



-- Kevin McKeever



SOURCE: Centocor Inc., news release, June 10, 2008


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