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Gold nanoparticles help target, quantify breast cancer segments in a living cell
Date:4/23/2014

WEST LAFAYETTE, Ind. - Purdue University researchers have developed a way to detect and measure cancer levels in a living cell by using tiny gold particles with tails of synthetic DNA.

A team led by Joseph Irudayaraj, professor of agricultural and biological engineering, used gold nanoparticles to target and bind to fragments of genetic material known as BRCA1 messenger RNA splice variants, which can indicate the presence and stage of breast cancer. The number of these mRNA splice variants in a cell can be determined by examining the specific signal that light produces when it interacts with the gold nanoparticles.

"This is a simple yet sophisticated technique that can be used to detect cancer in a single cell and determine how aggressive it is," said Irudayaraj, who is also the deputy director of the Bindley Bioscience Center. "Being able to quantify these genetic molecules could ultimately help clinicians provide better and more individualized treatment to cancer patients."

The technique also could increase our understanding of cell biology and paves the way for genetic profiling and diagnosis based on a single cell, Irudayaraj said.

BRCA1 is a tumor suppressor gene that can transform a cell into a cancerous type under certain circumstances. Measuring the number of BRCA1 mRNA splice variants in a cell can indicate if the gene is being under-expressed, a possible sign of breast cancer.

But current methods of detecting cancer rely on samples made up of hundreds or thousands of cells and cannot provide detailed information about how genes tied to cancer are being expressed in individual cells.

Irudayaraj and his team are the first to detect and quantify BRCA1 mRNA splice variants - fragments of genetic material that are removed when mRNA is formed - in a single cell. Splice variants can determine the fate of a cell and how specific proteins are expressed. Errors in the splicing process have been linked to a variety of diseases.
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Contact: Natalie van Hoose
nvanhoos@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

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