Navigation Links
Gold nanoparticles for controlled drug delivery
Date:12/30/2008

CAMBRIDGE, Mass. -- Using tiny gold particles and infrared light, MIT researchers have developed a drug-delivery system that allows multiple drugs to be released in a controlled fashion.

Such a system could one day be used to provide more control when battling diseases commonly treated with more than one drug, according to the researchers.

"With a lot of diseases, especially cancer and AIDS, you get a synergistic effect with more than one drug," said Kimberly Hamad-Schifferli, assistant professor of biological and mechanical engineering and senior author of a paper on the work that recently appeared in the journal ACS Nano.

Delivery devices already exist that can release two drugs, but the timing of the release must be built into the device it cannot be controlled from outside the body. The new system is controlled externally and theoretically could deliver up to three or four drugs.

The new technique takes advantage of the fact that when gold nanoparticles are exposed to infrared light, they melt and release drug payloads attached to their surfaces.

Nanoparticles of different shapes respond to different infrared wavelengths, so "just by controlling the infrared wavelength, we can choose the release time" for each drug, said Andy Wijaya, graduate student in chemical engineering and lead author of the paper.

The team built two different shapes of nanoparticles, which they call "nanobones" and "nanocapsules." Nanobones melt at light wavelengths of 1,100 nanometers, and nanocapsules at 800 nanometers.

In the ACS Nano study, the researchers tested the particles with a payload of DNA. Each nanoparticle can carry hundreds of strands of DNA, and could also be engineered to transport other types of drugs.

In theory, up to four different-shaped particles could be developed, each releasing its payload at different wavelengths.


'/>"/>

Contact: Jen Hirsch
jfhirsch@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1

Related medicine news :

1. Nanoparticles trigger cell death?
2. Consumers Union Urges FDA to Conduct Full Scale Safety Review of Nanoparticles in Sunscreen
3. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
4. New disease-fighting nanoparticles look like miniature pastries
5. Nanoparticles + light = dead tumor cells
6. Using magenetic nanoparticles to combat cancer
7. Nanoparticles aid bone growth
8. Magnetic nanoparticles: Suitable for cancer therapy?
9. Brown chemists create cancer-detecting nanoparticles
10. Iowa State University researcher looks to use nanoparticles for food safety
11. Symposium to explore role nanoparticles may play in disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 16, 2014 Holganix, an elite member ... growing companies in the country, produces an organic Bionutritional ... health-care by naturally decreasing disease and insect damage though ... that it will hold its third annual Bionutritional Summit ... 22, 2014 from 1:00 P.M. through 6:00 P.M., the ...
(Date:9/16/2014)... Recently, iFitDress.com, one of the most famous ... one shoulder evening gown collection. According to the company’s ... discounted rates (up to 69% off) at present. Additionally, all ... , “I am a frequent caller of your site. I ... dress, I feel quite happy. All items are of good ...
(Date:9/16/2014)... HealthDay Reporter TUESDAY, Sept. 16, 2014 ... human papillomavirus (HPV), which is linked to the risk of ... that testing urine for HPV has good accuracy when compared ... lead researcher Dr. Neha Pathak. She is a resident in ... of London, England. The test could be done at ...
(Date:9/16/2014)... These new programs allow those who haven’t owned a home ... in a 0% interest free, 2nd down payment assistance mortgage ... programs, are listed on their private website. The $10,000 does ... move out of the property. The down payment assistance 2nd ... monthly payments paid by the Borrower. The money is paid ...
(Date:9/16/2014)... September 14, 2014 A new study ... branch (SB) stenting of true coronary bifurcation lesions ... care. The DKCRUSH-VI clinical trial is the first ... , Findings were reported today at the 26th ... by the Cardiovascular Research Foundation (CRF), TCT is ...
Breaking Medicine News(10 mins):Health News:Holganix Holds 3rd Annual Bionutrional Summit in Louisville, Kentucky 2Health News:iFitDress.com: One Shoulder Evening Gown Collection Unveiled Online 2Health News:Urine Test for HPV Works Well, Analysis Finds 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 3Health News:Results of DKCRUSH-VI trial reported at TCT 2014 2
... Justice Department,today announced that it has reached a ... headquartered in Southfield, Mich., under the,Americans with Disabilities ... Clinic refused to serve a prospective client because ... today,s agreement, Medical Weight Loss Clinic will,provide training ...
... more than 40 percent of widowers in that country whose ... they were either never told that their spouse,s cancer was ... of her life. Eighty-six percent of widowers believed next-of-kin should ... 71 percent of the men who did not recall being ...
... Preventive Medicine, (http://www.USPreventiveMedicine.com ) the leader in disease ... its campaign to make the,United States a healthier ... Pediatrics, which this week called for children to ... the "Healthiest Nation Campaign," a program aimed,at placing ...
... in Oxygen Orders, Lack of,Trained Technicians, ARLINGTON, ... program for durable medical equipment has created,concern and ... medical equipment providers across the country since it,was ... The bidding program has triggered widespread disruptions ...
... Chicago is one of 11 centers in the United ... Clinical Islet Transplant Consortium funded by the National Institutes ... to test new approaches to islet transplantation that may ... adults with difficult-to-control type 1 diabetes. , Patients with ...
... team will give the men we serve a distinct advantage on, ... ... Directors, DETROIT, July 8 The Mariners Inn shelter ... executive officer and David Sampson as chief operating officer., "Both Jim and ...
Cached Medicine News:Health News:Justice Department Reaches Settlement Agreement With Medical Weight Loss Clinic 2Health News:Study finds that significant proportion of men told wife's cancer was incurable late or not at all 2Health News:U.S. Preventive Medicine Applauds Leading Health Organizations for Disease Prevention Platforms 2Health News:Medicare Bidding Program Creates Major Problems for Physicians, Hospitals, and Beneficiaries Seeking Home Medical Equipment 2Health News:Medicare Bidding Program Creates Major Problems for Physicians, Hospitals, and Beneficiaries Seeking Home Medical Equipment 3Health News:Medicare Bidding Program Creates Major Problems for Physicians, Hospitals, and Beneficiaries Seeking Home Medical Equipment 4Health News:Medicare Bidding Program Creates Major Problems for Physicians, Hospitals, and Beneficiaries Seeking Home Medical Equipment 5Health News:UIC in NIH-funded islet transplantation study for type 1 diabetes 2Health News:Mariners Inn Announces New Executive Leadership 2
(Date:9/16/2014)... , Sept. 16, 2014 EHE International, the recognized ... nationwide physician network, today announced that David Abrams M.D ... named an EHE-certified preventive care center. Through David Abrams ... region now have greater access to EHE,s preventive care ... "EHE is proud to add Dr. Abrams M.D. to its ...
(Date:9/16/2014)... BOSTON , Sept. 16, 2014 QPID ... a move to new headquarters in Boston ... The new headquarters will be at 175 Franklin Street in ... operations and marketing teams. QPID Health,s new Southern ... Parkway in Carlsbad.  The expansion will help meet the demands ...
(Date:9/16/2014)... 2014  Decision Resources Group finds that the rheumatoid arthritis (RA) ... to over $18.2 billion in 2023 in the United ... , Italy , Spain ... Japan . TNF-alpha inhibitors will remain the leading drug class ... growth will be constrained and patient shares will decline due to ...
Breaking Medicine Technology:EHE International Certifies David Abrams M.D. as Its Newest Partner 2QPID Health Announces Major Office Expansion in Boston and Opens Facility in San Diego 2The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 2The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 3
... myeloma is one,of the most common and devastating bone ... dramatically over the past decade. Recent,analyses suggest that this ... aggressive therapeutic interventions such as stem cell transplantation,according to ... the,official journal of the American Society of Hematology., ...
... 1 Regado Biosciences today announced,the enrollment ... open-label,randomized Phase IIa clinical study, named REVERSAL-PCI, ... enrolled at Black Hills Cardiology,in Rapid City, ... undergoing elective,Percutaneous Coronary Intervention (PCI) to assess ...
Cached Medicine Technology:Studies Attribute Recent Increase in Multiple Myeloma Survival to Novel Therapies 2Studies Attribute Recent Increase in Multiple Myeloma Survival to Novel Therapies 3Studies Attribute Recent Increase in Multiple Myeloma Survival to Novel Therapies 4Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System 2Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System 3
80 inch PVC tubing with connectors and 19 gauge straight, beveled cannula. Fits Bausch & Lomb Surgical cassettes. Allows the safe removal of silicone oil in 10 minutes or less. 3/Box...
... gauge, 25 mm cannula with 30 gauge, 4.76 ... mm flattened tip. Cannula is attached to a ... ID x 8 inch long), for use with ... other vitreo-retinal membranes using visco elastic materials. Flattened, ...
20 gauge x 25 mm cannula with 30 degree x 5 mm tip. 30 gauge cannula extends into hub 2 mm from end of hub. 10 per box....
Developed for oculoplastic procedures for corneal and scleral protection. Dimensions enable protector to rest on the sclera and not on the cornea. Easily removed with Bishop-Harmon Forceps. Individua...
Medicine Products: