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Gold nanoparticle probes may allow earlier cancer detection
Date:12/23/2007

of many human tumors including head and neck and lung carcinomas.

In the study, antibody-linked particles accumulate in tumors ten times more than particles without antibodies. However, both kinds of nanoparticles tended to accumulate in the liver and spleen over several days, the researchers found.

Dr. Nie says his lab plans to modify the coatings of the nanoparticles to improve tumor targeting. Eventually, he says, the gold particles could also be used to selectively deliver drugs to cancer cells.

The Nature Biotechnology report is a collaboration between first author Ximei Qian, PhD and graduate student Dominic Ansari in Dr. Nie's laboratory, Xiang-Hong Peng, MD PhD in Dr. Shin's laboratory and research specialist Qiqin Yin-Goen in the laboratory of Andrew Young, MD PhD, assistant professor of pathology and laboratory medicine.

Other Emory faculty investigators included Georgia Chen, PhD, associate professor of hematology and oncology and Lily Yang, MD, associate professor of surgery.

"The joint Department of Biomedical Engineering at Georgia Tech and Emory University provides an excellent environment for translating new biotechnologies into biomedical applications and clinical practice," Dr. Wang says.

"This work on cancer nanotechnology illustrates a significant collaboration involving five academic departments and four Georgia Cancer Coalition Scholars," Dr. Nie says. "It is also a product of inter-programmatic collaboration between two NIH-funded centers at Emory and Georgia Tech, one for cancer nanotechnology and one for studying head and neck cancer."


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Contact: Vince Dollard
vincent.dollard@emoryhealthcare.org
404-778-4580
Emory University
Source:Eurekalert

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