Going from ulcers to cancer ( Researchers have uncovered a big clu...)

Going from ulcers to cancer

Date:8/22/2008

Researchers have uncovered a big clue as to why some of the bacteria that cause stomach ulcers pose a greater risk for serious problems like stomach cancer than others; it turns out these bacteria can exploit the surrounding stomach cells to protect them from the immune system.

Helicobacter pylori is a bacterial strain that can infect the human stomach and induce inflammation, ulcers, and potentially even stomach cancer. However, only a small fraction of H. pylori infections ultimately lead to cancer, leading researchers to figure out what biological events will trigger this path.

One type of H. pylori strain that seems to increase disease risk is the cag+ strain, which contains a set of proteins that allows it to inject bacterial proteins into cells following attachment to the stomach lining; this interaction between bacteria and gastric cells may be a key contributor to chronic damage.

Richard Peek and colleagues investigated a cag+ strain in mouse models of H. pylori infection and found that a protein called CagE could induce gastric cells to turn on a receptor called Decay-accelerating factor (DAF); DAF acts to remove nearby immune proteins that can kill cells to prevent unwanted immune damage.

In essence, the bacteria use the DAF receptor on the host cell they're attached to like a bodyguard to protect them from the immune system. Peek and colleagues also note that by continually inducing DAF expression, H. pylori creates an environment of persistent inflammation that can reduce the threshold required for more serious diseases to develop.

'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

0

GOOD

Post Your Comments:

(Date:5/24/2013)... May 24, 2013 In a coup that ... Greg DeLange of the Estetica Institute of the Palm ... KOOL 105.5 FM’s popular morning show, “The Mo & Sally ... experiences and their satisfaction with the results, giving Dr. DeLange ... located in Palm Beach Gardens, very valuable free publicity. , ...

(Date:5/24/2013)... CBT News.com recently announced the addition of Tom ... automotive industry news organization with 12 years experience in online ... a group that’s so forward-thinking in their approach,” says Gonter. ... content is on the rise.” , Atlanta born and raised, ... into advertising at Cycle News and Boating World. He made ...

(Date:5/24/2013)... 24, 2013 The Institute for Integrative ... announce that it has donated $10,000 to the Cleveland ... captive in Cleveland, Ohio. , “When the news came out ... and Amanda Berry and her daughter had escaped from a ... were shocked and horrified,” said Integrative Nutrition Founder, Director, and ...

(Date:5/24/2013)... 24, 2013 The point-of-care (POC) ... used outside the central laboratory, by other healthcare ... practitioner or by consumers. This includes products that ... pregnancy, infectious and cardiovascular disease and cancer, as ... critical care, surgical and emergency departments. , Critical ...

(Date:5/24/2013)... first conference of its kind, Impacts World 2013 ... decision makers from politics, business and civil society ... climate impact research across sectors and scales. , ... 2013 on May 27th, 1pm to 1:55pm and ... Speakers include: , Connie Hedegaard, EU ...

Breaking Medicine News(10 mins):Health News:Dr. Greg DeLange of the Estetica Institute Recently Performed Eye Surgery on Both Members of Popular Morning Radio Team 2 Health News:Integrative Nutrition Donates $10,000 to the Cleveland Courage Fund 2 Health News:Point of Care Diagnostics Market (POC) Analysis and 5 Year Forecast in New Research Report at ReportsnReports.com 2 Health News:Point of Care Diagnostics Market (POC) Analysis and 5 Year Forecast in New Research Report at ReportsnReports.com 3

[0] Dr. Greg DeLange of the Estetica Institute Recently Performed Eye Surgery on Both Members of Popular Morning Radio Team [0] Tom Gonter to Drive Sales at Retail Automotive News Organization CBT News [0] Integrative Nutrition Donates $10,000 to the Cleveland Courage Fund [0] Point of Care Diagnostics Market (POC) Analysis and 5 Year Forecast in New Research Report at ReportsnReports.com [0] Impacts conference on climate change effects

... , , FRANKLIN ... (NYSE: MHS ), the world,s most advanced pharmacy(R) ... into a joint venture with United Drug plc, a Pan-European healthcare ... for patients covered by the country,s National Health Service (NHS). ...

... , MARINA DEL RAY, Calif., Aug. 12 Dr. ... to welcome Italian students from the University of L,Aquila by assisting ... school is being rebuilt after the devastating April 5th earthquake in ... who were displaced by the earthquake in L,Aquila, Italy, including the ...

... ISELIN, N.J., Aug. 12 Pharmos Corporation (Pink Sheets: PARS) today reported financial ... , Second Quarter Ended June 30, 2009 , ... or $0.05 per share, for the second quarter 2009 compared to a net ... Cash and cash equivalents totaled $2.9 million at June 30, 2009. , ...

... have given for years , WEDNESDAY, Aug. 12 (HealthDay News) ... painful swelling of the arm that often occurs after breast ... to what women have been told for years -- that ... other exercise because muscle strain can cause lymphedema to worsen. ...

... Goal is to help patients who might benefit from ... By clarifying rules governing patient access to so-called investigational ... to expand the number of people who might benefit ... can get the drugs hasn,t changed, but there is ...

... , WASHINGTON, Aug. 12 During a town ... stated his opposition to legislation that would cover illegal aliens. Specter ... was the author of the 2006 amnesty bill (S. 2611) that ... illegal aliens under the proposed reforms is a clear indication of ...

Medco Health Solutions, United Drug Announce U.K. Homecare Pharmacy Joint Venture Serving Patients with Chronic and Complex Health Conditions; Innovations to Improve Clinical Quality, Reduce Costs Heritage Provider Network and Dr. Richard Merkin Come to the Aid of Italian Earthquake Victims Pharmos Corporation Reports 2009 Second Quarter Results Weight Lifting Can Ease Arm Swelling in Breast Cancer Survivors FDA Details Access to 'Investigational' Drugs Specter Promises to Oppose Health Care Reform That Covers Illegal Aliens

(Date:5/23/2013)... 2013 TeamHealth Medical Call Center (THMCC), a ... advice lines, announces its newly formed Clinical Advisory ... administrative leaders, provides clinical expertise to advance THMCC,s ... for hospital clients, physician clients and patients. ... it,s imperative to continuously advance our services and ...

(Date:5/23/2013)... 23, 2013 More than half of women ... from chemotherapy and still have excellent outcomes. To educate ... of the largest sources of online consumer information about ... Facebook page provide recently diagnosed women with information sources, ... chemotherapy. "We anticipate these innovative social media ...

(Date:5/23/2013)... May 23, 2013 Anthem Blue Cross patients ... have required them to obtain their medications by mail ... and Whatley Kallas LLC. The lawsuit, ... that Blue Cross,s mandatory mail order program announced late ... and privacy. "This settlement brings to a ...

Breaking Medicine Technology:TeamHealth Medical Call Center Forms Clinical Advisory Committee 2 Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 2 Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 3 Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 2 Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 3

[0] TeamHealth Medical Call Center Forms Clinical Advisory Committee [0] Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions [0] Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog

... ... ... ... ...

Cached Medicine Technology:Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 2 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 3 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 4 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 5 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 6 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 7 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 2 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 3 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 4 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 5 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 6 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 7

Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International

... The Isoseeds I-125 are brachytherapy sources which ... of localized tumors, especially in the prostate. ... the conclusion of the therapeutic effect, i.e. ... are intended for single use. They are ...

... Four 64 mirrors for complete anterior ... rotation. Directly hand held for easy ... small holding ring. Small diameter contact ... without methylcellulose. Advanced technology, multi-layer polymer ...

... Three mirrors of 64, 67 ... diameter contact surface for use ... be viewed through the central ... polymer coating protects mirrors and ...

West lacrimal cannula blunt tip with side port....

Medicine Products:

IsoSeed I-125 (I25.S06)Ocular Sussman Four Mirror Hand Held Gonioscope Ocular Three Mirror 10 mm Gonio West Cannula