Navigation Links
Going from ulcers to cancer
Date:8/22/2008

Researchers have uncovered a big clue as to why some of the bacteria that cause stomach ulcers pose a greater risk for serious problems like stomach cancer than others; it turns out these bacteria can exploit the surrounding stomach cells to protect them from the immune system.

Helicobacter pylori is a bacterial strain that can infect the human stomach and induce inflammation, ulcers, and potentially even stomach cancer. However, only a small fraction of H. pylori infections ultimately lead to cancer, leading researchers to figure out what biological events will trigger this path.

One type of H. pylori strain that seems to increase disease risk is the cag+ strain, which contains a set of proteins that allows it to inject bacterial proteins into cells following attachment to the stomach lining; this interaction between bacteria and gastric cells may be a key contributor to chronic damage.

Richard Peek and colleagues investigated a cag+ strain in mouse models of H. pylori infection and found that a protein called CagE could induce gastric cells to turn on a receptor called Decay-accelerating factor (DAF); DAF acts to remove nearby immune proteins that can kill cells to prevent unwanted immune damage.

In essence, the bacteria use the DAF receptor on the host cell they're attached to like a bodyguard to protect them from the immune system. Peek and colleagues also note that by continually inducing DAF expression, H. pylori creates an environment of persistent inflammation that can reduce the threshold required for more serious diseases to develop.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related medicine news :

1. American Red Cross on the Gulf Coast: Storms Coming and Going
2. Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame
3. Beleaguered Howe Developmental Center Remains Open Despite Additional Deaths and Ongoing Violations of Human Rights
4. Going Online to Draw the Line on High Blood Pressure
5. 228 People in 22 States Sickened in Ongoing Salmonella-Tomato Outbreak
6. Research shows patients must re-learn going from sitting to standing after total knee replacement
7. Eleven Going on 70: SCAN Health Plan Helps Fifth Graders Understand Aging Through First-Ever Senior Sensitivity Training for Kids
8. Charitable Donations to Private Organizations in Haiti Critical Component to Ongoing Food Crisis Relief Efforts
9. Ongoing study continues to show that extra sleep improves athletic performance
10. Sen. Kennedy Undergoing Surgery for Brain Tumor
11. More Young People Going Without Health Insurance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating ... , As the stress of modern life continually makes more demands on time and ... artificial stimulants can trap people in vicious high/low cycles and can also cause long ...
(Date:8/21/2017)... ... August 22, 2017 , ... PracticeMatch, a company that provides online ... with physicians and advanced practitioners like nurse practitioners and physician assistants ... through November of this year. The online career fairs will allow job seekers to ...
(Date:8/21/2017)... ... 21, 2017 , ... Los Angeles area medical group Beverly ... year 2017-2018, Christina M. Busuito, M.D. and Lukasz Swistun, M.D. This one year ... Reconstructive Surgery. The candidate will have the opportunity to work with leading ...
(Date:8/21/2017)... California (PRWEB) , ... August 21, 2017 , ... Five ... money and awareness for Alzheimer’s Family Center. , Guests will be able to ... Newport Beach Plaza, Braised Lamb Shank with Fennel Dill Salad, Feta Cheese Sauce & ...
(Date:8/21/2017)... ... ... The experts have spoken. Prolonged sitting and standing are a no-no for ... healthy way these days? FlexiSpot, one of the fastest-growing manufacturers of ergonomic office solutions, ... Deskcise Pro™– the world’s first sit-stand-cycle desk to backers worldwide. , The Launch , ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO), has been named one ... by Crain,s Detroit Business . The annual ... three-year revenue growth. This year,s edition measures growth from 2013 ... the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... said Phil Hagerman , CEO and chairman of Diplomat. ...
(Date:7/28/2017)... CHICAGO, July 28, 2017 Hill-Rom Holdings, Inc. ... fiscal third quarter ended June 30, 2017, and updated ... For the fiscal third quarter, ... to $0.68 per diluted share in the prior-year period. ... of $0.39 per diluted share primarily related to the ...
(Date:7/27/2017)... 2017  West Pharmaceutical Services, Inc. (NYSE: ... second-quarter 2017 and updated financial guidance for the full-year ... Highlights Reported net sales of $397.6 ... quarter. Net sales at constant currency (organic) grew by ... $0.51, compared to $0.60 in the prior-year quarter. Second-quarter ...
Breaking Medicine Technology: