Navigation Links
Going from ulcers to cancer

Researchers have uncovered a big clue as to why some of the bacteria that cause stomach ulcers pose a greater risk for serious problems like stomach cancer than others; it turns out these bacteria can exploit the surrounding stomach cells to protect them from the immune system.

Helicobacter pylori is a bacterial strain that can infect the human stomach and induce inflammation, ulcers, and potentially even stomach cancer. However, only a small fraction of H. pylori infections ultimately lead to cancer, leading researchers to figure out what biological events will trigger this path.

One type of H. pylori strain that seems to increase disease risk is the cag+ strain, which contains a set of proteins that allows it to inject bacterial proteins into cells following attachment to the stomach lining; this interaction between bacteria and gastric cells may be a key contributor to chronic damage.

Richard Peek and colleagues investigated a cag+ strain in mouse models of H. pylori infection and found that a protein called CagE could induce gastric cells to turn on a receptor called Decay-accelerating factor (DAF); DAF acts to remove nearby immune proteins that can kill cells to prevent unwanted immune damage.

In essence, the bacteria use the DAF receptor on the host cell they're attached to like a bodyguard to protect them from the immune system. Peek and colleagues also note that by continually inducing DAF expression, H. pylori creates an environment of persistent inflammation that can reduce the threshold required for more serious diseases to develop.


Contact: Nick Zagorski
American Society for Biochemistry and Molecular Biology

Page: 1

Related medicine news :

1. American Red Cross on the Gulf Coast: Storms Coming and Going
2. Vote now for an Everyday Person with Never-Quit Spirit to join the Energizer(R) Keep Going(R) Hall of Fame
3. Beleaguered Howe Developmental Center Remains Open Despite Additional Deaths and Ongoing Violations of Human Rights
4. Going Online to Draw the Line on High Blood Pressure
5. 228 People in 22 States Sickened in Ongoing Salmonella-Tomato Outbreak
6. Research shows patients must re-learn going from sitting to standing after total knee replacement
7. Eleven Going on 70: SCAN Health Plan Helps Fifth Graders Understand Aging Through First-Ever Senior Sensitivity Training for Kids
8. Charitable Donations to Private Organizations in Haiti Critical Component to Ongoing Food Crisis Relief Efforts
9. Ongoing study continues to show that extra sleep improves athletic performance
10. Sen. Kennedy Undergoing Surgery for Brain Tumor
11. More Young People Going Without Health Insurance
Post Your Comments:
(Date:12/1/2015)... Viejo, CA (PRWEB) , ... December 01, 2015 , ... ... length of footage, and with full control over customization, the possibilities are truly endless, ... frame rate, position randomization, overlay depth position, vertical flip, horizontal flip, depth of field ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... receiving the 2015 HSJ Acute Sector Innovation Award on November 18th. This prestigious ... care experience, and propose exciting enhancements to the medical landscape. , The UCLH ...
(Date:11/30/2015)... Cary, NC (PRWEB) , ... November 30, 2015 ... ... Dominique Dawes, Amanda Beard and Brooke Bennett are collaborating with brands across various ... , These four influential figures make up an elite group of Gold Medal ...
(Date:11/30/2015)... , ... December 01, 2015 , ... ... Christina Colon as a 2015-2016 inductee into its VIP Woman of the ... NAPW is the nation’s leading networking organization exclusively for professional women, boasting 850,000 ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... programs of the19th Bi-National Convention of the Federation of Philippine American Chambers of ... in Las Vegas, Nevada. , 1Heart Caregiver Services, as an active delegate ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... VERONA, Virginia , 1 de diciembre ... líder en tecnología para cuchillas de precisión, ... un programa de identidad de marca. El ... en el diseño y la ingeniería de ... toda la diferencia". ...
(Date:12/1/2015)... , Dec. 1, 2015 During the ... San Francisco, CA , Medinol ... the coronary marketplace. During a satellite symposium, "The ... Design to Minimize Restenosis", a renowned physician panel ... Medinol NIRxcell™ CoCr Coronary Stent System and the ...
(Date:12/1/2015)... YORK , Dec. 1, 2015 Relmada Therapeutics, ... the treatment of chronic pain, announced today that the company ... will be held December 1-3 at the Luxe Sunset Boulevard ... Sergio Traversa , CEO of Relmada Therapeutics, will present on ... Eastern Time). . Please register at least ...
Breaking Medicine Technology: