Navigation Links
Going Straight to Chemo May Be Better for Certain Breast Cancers

TUESDAY, Sept. 6 (HealthDay News) -- Breast cancer patients with the BRCA1 gene mutation have a much better response to neoadjuvant chemotherapy -- chemo given before other treatment -- than other breast cancer patients, a new study finds.

U.S. researchers looked at 317 patients with different stages of breast cancer who underwent neoadjuvant chemotherapy.

Complete pathological response (pCR) -- the disappearance of all evidence of cancer from the breast tissue and lymph nodes -- occurred in 46 percent of those with the BRCA1 mutation, 13 percent of those with the BRCA2 mutation, and 22 percent of patients with neither mutation, the study authors found.

BRCA1 carriers who achieved a pCR after neoadjuvant chemotherapy also had a better five-year, relapse-free survival and overall survival rates, although the latter difference was not statistically significant, said the University of Texas M.D. Anderson Cancer Center researchers.

After neoadjuvant chemotherapy, 61 patients had breast-conserving surgery and 256 underwent mastectomy.

"While hereditary breast cancers typically carry aggressive tumor features compared to sporadic [non-inherited] breast cancers, we found that BRCA1-related tumors were as responsive and sensitive to anthracycline and taxane-based chemotherapy as were sporadic breast cancers," lead author Dr. Banu Arun, a professor in the department of breast medical oncology, said in an M.D. Anderson news release. "These findings may help physicians determine the best treatment method for this subset of women with unique genetic mutations."

The study is published in the Sept. 6 online edition of the Journal of Clinical Oncology.

A lack of prospective studies means there is no consensus on the most effective chemotherapy regimen for breast cancer patients with a BRCA1 mutation, according to Arun.

"This new insight tempts us to speculate that the presence of the BRCA1 mutation determines how some women will respond to neoadjuvant chemotherapy. However, we need future prospective studies with larger cohorts and longer-term follow up to validate these findings and determine optimum treatment," Arun said in the news release.

More information

The U.S. National Cancer Institute explains adjuvant and neoadjuvant therapy for breast cancer.

-- Robert Preidt

SOURCE: University of Texas M.D. Anderson Cancer Center, news release, Sept. 6, 2011

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Going Full-Tilt Into Turns May Ease Motion Sickness on Trains
2. Afghan Medical Staff Face Ongoing Security Threats: Study
3. More People May Benefit From Going Gluten-Free
4. Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications
5. Ongoing relationship with care provider key for patients with a chronic condition: UBC study
6. Researchers find many elderly men are undergoing unnecessary PSA screenings
7. Negative attitudes toward fat bodies going global, study finds
8. Going Green May Cut Hospital Costs
9. Many Higher-Income Parents Forgoing Kids Vaccinations: Report
10. Younger Men Not Going to the Doctor Enough, Survey Shows
11. Studies identify complications in women undergoing mastectomy and immediate breast reconstruction
Post Your Comments:
Related Image:
Going Straight to Chemo May Be  Better for Certain Breast Cancers 
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research ... Pharma News Issue 52" report to their offering. ... in influenza treatment creates a favourable commercial environment for MedImmune ... growing patient base that will serve to drive considerable growth ... vaccine would serve to cap sales considerably, but development is ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
Breaking Medicine Technology: