Navigation Links
Going Straight to Chemo May Be Better for Certain Breast Cancers
Date:9/6/2011

TUESDAY, Sept. 6 (HealthDay News) -- Breast cancer patients with the BRCA1 gene mutation have a much better response to neoadjuvant chemotherapy -- chemo given before other treatment -- than other breast cancer patients, a new study finds.

U.S. researchers looked at 317 patients with different stages of breast cancer who underwent neoadjuvant chemotherapy.

Complete pathological response (pCR) -- the disappearance of all evidence of cancer from the breast tissue and lymph nodes -- occurred in 46 percent of those with the BRCA1 mutation, 13 percent of those with the BRCA2 mutation, and 22 percent of patients with neither mutation, the study authors found.

BRCA1 carriers who achieved a pCR after neoadjuvant chemotherapy also had a better five-year, relapse-free survival and overall survival rates, although the latter difference was not statistically significant, said the University of Texas M.D. Anderson Cancer Center researchers.

After neoadjuvant chemotherapy, 61 patients had breast-conserving surgery and 256 underwent mastectomy.

"While hereditary breast cancers typically carry aggressive tumor features compared to sporadic [non-inherited] breast cancers, we found that BRCA1-related tumors were as responsive and sensitive to anthracycline and taxane-based chemotherapy as were sporadic breast cancers," lead author Dr. Banu Arun, a professor in the department of breast medical oncology, said in an M.D. Anderson news release. "These findings may help physicians determine the best treatment method for this subset of women with unique genetic mutations."

The study is published in the Sept. 6 online edition of the Journal of Clinical Oncology.

A lack of prospective studies means there is no consensus on the most effective chemotherapy regimen for breast cancer patients with a BRCA1 mutation, according to Arun.

"This new insight tempts us to speculate that the presence of the BRCA1 mutation determines how some women will respond to neoadjuvant chemotherapy. However, we need future prospective studies with larger cohorts and longer-term follow up to validate these findings and determine optimum treatment," Arun said in the news release.

More information

The U.S. National Cancer Institute explains adjuvant and neoadjuvant therapy for breast cancer.

-- Robert Preidt

SOURCE: University of Texas M.D. Anderson Cancer Center, news release, Sept. 6, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Going Full-Tilt Into Turns May Ease Motion Sickness on Trains
2. Afghan Medical Staff Face Ongoing Security Threats: Study
3. More People May Benefit From Going Gluten-Free
4. Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications
5. Ongoing relationship with care provider key for patients with a chronic condition: UBC study
6. Researchers find many elderly men are undergoing unnecessary PSA screenings
7. Negative attitudes toward fat bodies going global, study finds
8. Going Green May Cut Hospital Costs
9. Many Higher-Income Parents Forgoing Kids Vaccinations: Report
10. Younger Men Not Going to the Doctor Enough, Survey Shows
11. Studies identify complications in women undergoing mastectomy and immediate breast reconstruction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Going Straight to Chemo May Be  Better for Certain Breast Cancers 
(Date:2/11/2016)... ... 12, 2016 , ... The Journal of Pain Research has seen ... SJR uses data taken from the Scopus database (Elsevier B.V.) and is a measure ... by the journal over a three year period and also the importance of the ...
(Date:2/11/2016)... ... 11, 2016 , ... The president released a FY 2017 budget request on ... more of the cost burden to military beneficiaries. , MOAA’s president, retired Air ... budget as including limited quantifiable benefit fixes mixed with numerous beneficiary fee hikes. , ...
(Date:2/11/2016)... ... February 11, 2016 , ... Hall Integrative Health and ... for their simultaneous grand openings in March. All seven practices are set to ... wondering, is reversing diabetes possible? According to this 2011 CNN article it is ...
(Date:2/11/2016)... ... 2016 , ... Thermi™, a world leader in thermistor-regulated energy ... promotions of Allison Kelly to executive vice president of the company’s new North ... North American capital sales, and Wendy Oseas to vice president of global marketing. ...
(Date:2/11/2016)... ... 11, 2016 , ... Atlantic Information Services, Inc. (AIS) is ... Case Study for Plans and Purchasers.” Executives from Intel Corp. and Providence Health ... value-based health benefits program Connected Care, will discuss the challenges they faced (and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016 Jeffrey Zucker , ... Trials, will present at this year,s Summit for Clinical Operations ... in Miami, FL. Zucker will discuss ... study execution, supporting SCOPE,s "Improving Site Study Activation and Performance" ... Thursday, Feb. 25 at 11:05 a.m. --> ...
(Date:2/11/2016)... , February 11, 2016 F ... answers at the ... a world-leading provider of scientific, technical and medical information products and services, ... to evidence-based, peer reviewed clinical information via a mobile device. Elsevier designed ... ClinicalKey for Nursing. The new app is available in Android ...
(Date:2/11/2016)... Feb. 11, 2016 Exactus Pharmacy Solutions, ... high-quality specialty pharmacy care for those suffering from ... has achieved full Specialty Pharmacy Accreditation from URAC, ... to promoting health care quality through accreditation, education ... --> The URAC accreditation process demonstrates a ...
Breaking Medicine Technology: