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Glutamate Identified As Predictor of Disease Progression in Multiple Sclerosis
Date:4/30/2009

lism byproducts in the brain, and the results strongly support the link between the excess of glutamate and decline of neuro-axonal integrity in MS.

The finding, Pelletier says, goes beyond MS. "Now that we have those markers, we can quantify levels of glutamate for other neurologic diseases, which could be another way to track disease progression and therapeutic intervention."

The UCSF study, known as the EPIC MRI Study, aims to develop reliable genetic biomarkers that correlate with quantitative Magnetic Resonance Imaging (MRI) measures of disease burden and severity. Participants are involved for at least two years and receive an annual brain MRI.

Additional UCSF authors are Sarah J. Nelson, PhD, chair, Division of Bioengineering; John Kornak, PhD, assistant adjunct professor of Radiology; Darin T. Okuda, MD, assistant clinical professor in Neurology; and Bill Chu, specialist in Radiology.

The study was funded in part by the National MS Society.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. For further information, visit www.ucsf.edu.

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Read the full story at http://www.prweb.com/releases/UCSF_Glutamate/Multiple_Sclerosis/prweb2367794.htm.


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