Navigation Links
Glutamate Identified As Predictor of Disease Progression in Multiple Sclerosis
Date:4/30/2009

for MS suggests a new way for clinicians to monitor treatment of these drugs.

"This is the first time that we have had the ability to measure glutamate toxicity in the brain in real time, which gives us a marker for monitoring disease progression as well as our treatment of the disease," said Daniel Pelletier, MD, study author, associate professor of neurology and a member of the Multiple Sclerosis Research Group at the University of California, San Francisco.

"For instance, we already have anti-glutamate drugs, so now we can assess, with imaging, the impact of the therapy and the progression of the disease," he said.

Elevated levels of glutamate in the brain are understood clinically as a cause of cell injury and death. Injury to neuro-axons, which are the long fibers that extend from the cell body of a neuron cell toward other nerve cells, is partly responsible for disability progression in MS. In a previous study using proton MR spectroscopic imaging, the research team reported that MS brains have significant elevation of glutamate concentrations. For this study, researchers looked for levels of glutamate and levels of NAA (n-acteylaspartate), a marker of axonal integrity in mature brains, to see if a relationship existed.

The team scanned 265 MS patients annually and followed them for an average of 1.8 years. Accounting for disease duration and age of onset, researchers found that significant annual loss of NAA, which is a measure of neurodegeneration, was associated with concentration of glutamate. This finding indicated that the higher the level of glutamate, the greater the expected neuro-axonal loss over time.

According to the authors, the study is the largest clinical analysis to date of metabo
'/>"/>

Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Migraine prevention by targeting glutamate receptors?
2. Glutamate: Too much of a good thing in schizophrenia?
3. Webinar on June 25 to Focus on Opportunity for Treating Chronic Pain, Migraine and Muscle Spasticity Through Inhibition of Neurotransmitter Glutamate
4. TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack
5. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
6. Early-stage lung cancer identified using computer-aided system
7. New risk variant for atopic dermatitis identified
8. Eye Cells Believed to Be Retinal Stem Cells Are Misidentified
9. New target for heart failure therapy identified
10. WNS Identified at Six Sites in Pennsylvania
11. Compounds that trigger beta cell replication identified by JDRF funded researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... 2015 “ Food Cost Calculator ” was ... takes a look at the latest and coolest applications on ... host of AppWatch and technology expert, conducted the app review ... to manage and efficiently calculate food costs. , The restaurant ... fact, the industry has an estimated 1.8 trillion dollar impact ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Fast on ... Gladen’s documentary Trace Amounts, and Allison Folmar, JD, join ... conference held internationally. , On Sunday, May 24, the ... from autism possible?" Are you interested in Ryan Hinds' ... There: winning our war against autism was written ...
(Date:5/4/2015)... May 04, 2015 The ... released the first-ever congenital heart disease (CHD) ... Laboratory (PCCL) accreditation. Driven by the latest ... a comprehensive review of interventional procedures in ... disease. , “The ACE CHD Standards for ...
(Date:5/4/2015)... 04, 2015 Peacock Alley knows ... He said, “My mother was the most beautiful woman I ... in lovely, feminine prints and textures to remind ... further than the Eloise Robe to get you there. The ... cap sleeve and tapered waist. It is available in small/medium ...
(Date:5/4/2015)... “St. Louis has long represented opportunity and ... so it is the perfect place for Zerorez to ... Litalien, Chief Development Officer for Zerorez. “We have ... provide veterans with a $10,000 discount on our franchise ... a number of Military Veterans in its ranks including ...
Breaking Medicine News(10 mins):Health News:An Application to Manage a Successful Restaurant Was Featured on NewsWatch Television 2Health News:Perhaps the most important information families touched by autism will ever hear is available this month at international conference in Chicago 2Health News:Perhaps the most important information families touched by autism will ever hear is available this month at international conference in Chicago 3Health News:Perhaps the most important information families touched by autism will ever hear is available this month at international conference in Chicago 4Health News:Accreditation for Cardiovascular Excellence (ACE) Publishes New Standards for Pediatric and Adult Congenital Cardiac Catheterization Laboratories 2Health News:Feminine Classics for Mother's Day Gifts from Peacock Alley 2Health News:Zerorez® Creates “Gateway” for Veterans--Announces VetFran Participation. Plans Expansion into the St. Louis Region. 2Health News:Zerorez® Creates “Gateway” for Veterans--Announces VetFran Participation. Plans Expansion into the St. Louis Region. 3
... March 14 The American public,believes doctors and physicians ... and they want doctors to make decisions about patient ... be allowed to own,hospitals where they work and that ... A recent Lake Research Partners, national survey(1) shows ...
... were African-American were much more likely to suffer ... Surgery may provide only short-term relief for some ... Children,s Hospital Medical Center. , Adenotonsillectomy surgery is ... (SDB) in children. It is the most common ...
... 14 Sergeant,s Pet Care Products,today announces ... of Virbac,Corporation. The brands and technology acquired ... include internal and external health care,products, dental ... recognized,brands include WormXPlus(TM), WormX(R), Petrodex(R), Zema(R), Mardel(R),and ...
... report, COLORADO SPRINGS, Colo., March 14 ... for heart disease as early as,the toddler years, ... Conference on Cardiovascular Disease Epidemiology and,Prevention., It ... cardiovascular disease in,adults are initiated and progress silently ...
... is available in French and German . ... basic biological questions ranging from the role of lipids in ... 79 research groups include 39 from the two federal polytechnic ... Swiss universities, one group is part of the Swiss Institute ...
... not always manifested in children as dejection and anhedonia. ... features may be weeping, irritability or defiance, as explained ... Ulm University in the new edition of Deutsches rzteblatt ... signs of depression in infants are often screaming, restlessness, ...
Cached Medicine News:Health News:New Poll From Lake Research Shows Americans Support Allowing Physicians to Own and Operate Hospitals 2Health News:New Poll From Lake Research Shows Americans Support Allowing Physicians to Own and Operate Hospitals 3Health News:Surgery Only Works for Some Kids with Sleep Apnea 2Health News:Sergeant's(R) Pet Care Products Acquires the Consumer Brand Division of Virbac Corporation 2Health News:Toddlers Affected Most by Secondhand Smoke Exposure at Home 2Health News:Toddlers Affected Most by Secondhand Smoke Exposure at Home 3Health News:Toddlers Affected Most by Secondhand Smoke Exposure at Home 4Health News:Swiss Systems Biology Initiative announces Flagship Projects 2
(Date:5/4/2015)... 2015  Lors du salon Control 2015 de ... 5510), North Star Imaging Europe (NSI, www.4nsi.eu ... spécialement conçu pour la métrologie. Cette nouvelle machine ... la CXMM 50, a été développée dès le ... à offrir à l,utilisateur un outil de développement ...
(Date:5/4/2015)... HAVEN, Conn. , May 4, 2015 /PRNewswire/ ... chosen by the American Optometric Association (AOA) to ... delivery and outcomes for the millions of patients ... Measures and Outcomes Registry for Eyecare (MORE) ... will securely facilitate efficient secondary uses of essential ...
(Date:5/4/2015)... EspeRare today announced that the ... Designation (ODD) for rimeporide, its lead compound for the ... rare, life-threatening disease affecting boys early in childhood that ... most common and serious form of paediatric muscular dystrophies. ... inhibitor, originally developed by Merck Serono in the intended ...
Breaking Medicine Technology:NSI sera présente lors du salon Control 2015, du 5 au 8 mai à Stuttgart, en Allemagne : axer la GMAO vers une nouvelle dimension 2American Optometric Association, Prometheus Research to Create Transformative Health Outcomes Registry 2EspeRare's Investigational Compound Rimeporide Receives European Orphan Drug Designation in Duchenne Muscular Dystrophy 2
... BOSTON, Aug. 23 Do people cringe when you,sing? ... 1 in 20,people truly has amusia, the technical term ... bad singing voices hear music just fine.,Amusics are a ... out,differences in pitch or follow the simplest tunes, reports ...
... Iomai Corporation,(Nasdaq: IOMI ) today announced that ... double-blind Phase 2 field study of a patch-based,vaccine ... "late breaker",presentation at Interscience Conference on Antimicrobials and ... to 20. The abstract, "Transcutaneous Immunization with ...
Cached Medicine Technology:Tone Deafness Explained, from the Harvard Health Letter 2Iomai Announces Data from Phase 2 Field Study of Travelers' Diarrhea Vaccine Accepted for Presentation at ICAAC 2
The unique MR-frame and its indicators are made of a highly tensile and fibre reenforced Epoxyd material....
VG2 PLIF (Trapezoid) Posterior lumbar interbody fusion. Frozen preservation. Consists of two outer cortical planks, center cancellous plank, all from the same donor, held together by two press-fit co...
VG1 ALIF (Anterior) Anterior lumbar interbody fusion. Frozen freeze-dried preservation....
Allograft implants can be easily used to repair and promote the healing of a wide variety of bone and other tissue defects....
Medicine Products: