Navigation Links
Global platelet reactivity identifies high risk ACS patients
Date:8/28/2012

Munich, Germany August 26 2012: Global platelet reactivity is more effective than responsiveness to clopidogrel in identifying acute coronary syndrome (ACS) patients at high risk of ischemic events, according to research presented at the ESC Congress today. The results from the RECLOSE 2-ACS study were presented by Dr Rossella Marcucci from Italy.

The Responsiveness to Clopidogrel and Stent thrombosis 2 ACS (RECLOSE 2-ACS) study is a prospective, observational, referral center cohort study of 1,789 patients with acute coronary syndromes undergoing percutaneous coronary intervention (PCI) at the Division of Cardiology, Careggi Hospital, Florence, Italy.

Dual antiplatelet therapy with aspirin and clopidogrel is the cornerstone of therapy in these patients to improve prognosis and reduce adverse cardiovascular events, stent thrombosis and cardiovascular death.

"In recent years, we and other groups have focused our attention on the role of platelet inhibition," said Dr Marcucci. "We found that a significant percentage of patients on clopidogrel therapy the so-called nonresponders to clopidogrel had a high platelet reactivity (HPR) on clopidogrel and a significantly higher risk of developing an adverse ischemic event at a follow-up of 2 years."

A number of genetic and acquired conditions are associated with a high platelet reactivity on clopidogrel. Carriers of a genetic variant (the CYP2C19*2 polymorphism), diabetics, older patients, females and patients with a reduced renal and cardiac function have a higher risk of maintaining a high platelet reactivity on clopidogrel. In addition, the concomitant use of drugs such as proton pump inhibitors (PPIs) is associated with a reduced metabolization of clopidogrel (which is a prodrug and needs to be metabolized to the active drug by the liver) and a high risk of high platelet reactivity.

The aim of the current study was to evaluate whether a high platelet reactivity due to n
'/>"/>

Contact: ESC Press Office
press@escardio.org
49-176-104-18223
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Global platelet reactivity and high risk ACS patients
2. Global study suggests need for strategies to combat unhealthy lifestyles among the poor and the rich
3. New technology combats global pandemic of drug counterfeiting
4. Global Tobacco Use Remains High, Survey Finds
5. Global health researchers urge integrating de-worming into HIV care in Africa
6. Global sleeplessness epidemic affects an estimated 150 million in developing world
7. Keystone Symposia announces new 3-year grant to tackle major global health challenges
8. Conference brings global focus to social inequality
9. Global Budget Payment Model lowers medical spending, improves quality
10. High-level commission finds an epidemic of bad laws is stifling the global AIDS response
11. Dr. Prabhat Jha, global health researcher, appointed to Order of Canada
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 31, 2014 This Method to ... health effects for practitioners. , The Hypopresive ... of Science and Movement specializing in physical rehabilitation. ... pelvic floor reeducation that traditional abdominal exercises after ... Recti, Prolepses, etc. , The Hipopressives exercises pull ...
(Date:10/31/2014)... October 31, 2014 Activz Whole-Food ... Activz Silver line offering natural silver healing support† ... over a century, silver has been used to support ... Silver products is the most advanced version available. This ... unique chemical structure that supports the existing healing mechanisms ...
(Date:10/31/2014)... 31, 2014 (HealthDay News) -- Sleep apnea may make it ... you parked your car or left your house keys, a ... sleep apnea showed that this ability -- called spatial memory ... (REM) sleep, even when other stages of sleep weren,t affected. ... dreams typically occur. "We,ve shown for the first time ...
(Date:10/31/2014)... New research suggests that insomnia is a major contributor ... unintentional fatal injuries. The results underscore the importance of ... Healthy Sleep Awareness Project. , Results show that the ... manner with the number of insomnia symptoms present. People ... more likely to die from a fatal injury than ...
(Date:10/31/2014)... Santa Barbara, CA (PRWEB) October 31, 2014 ... for holiday shoppers to find affordable but tasteful gifts for ... special 22nd Annual Early Bird Gift Giving Special , ... percent off when they purchase Wine Club Gift membership. ... to take advantage of this special. Besides offering discounts, Gold ...
Breaking Medicine News(10 mins):Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 2Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 3Health News:New Collection of Nano-particle Natural Silver Products by Activz Whole-Food Nutrition 4Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Insomnia increases risk of motor vehicle deaths, other fatal injuries 2Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2
... of bioabsorbable polymers, Zeus presents free webinar on August 28, 2008. ... ... Zeus, Inc., a leader in polymer science, is pleased to announce ... "Bioabsorbable Polymers as Biomaterials." , , ,Presented by Dr. Bruce Anneaux ...
... Health Solutions Corp.,("SXC" or the "Company") (NASDAQ: ... benefits management services, announces that Mark Thierer,President and ... the 2008 Thomas,Weisel Partners Healthcare Conference at the ... take place on Wednesday, September,3, 2008 at 2:40 ...
... Aug. 21 Hospira, Inc.,(NYSE: HSP ... delivery,company, today announced new national agreements with ... Premier,s 2,000 member,hospitals with access to special ... general-purpose medication infusion devices, related,sets and disposables, ...
... WASHINGTON, Aug. 21 The following was,released by ... Galen Institute - founder of a public policy,research ... reform, Melinna Giannini, Founder & CEO, ABC ... billing platform that helps connect health care,professionals with ...
... Bodaken,Chairman, President & CEO of Blue Shield of California ... Roundtable on Health, Wellness and,Prevention at the start of ... a.m. MDT at Boettcher Hall in the Denver Performing,Arts ... programs,in health reform, and the ways in which health ...
... Meridian International,Center today announced that its board member, ... lead Meridian,s new Global Health,Program. The Global Health ... that include world affairs public briefings and conferences, ... and,cultural activities., "Today, 79% of people suffering ...
Cached Medicine News:Health News:Zeus Webinar: Bioabsorbable Polymers as Biomaterials 2Health News:Hospira Announces New Contracts With Premier Purchasing Partners for Infusion Devices, Solutions And Equipment 2Health News:Blue Shield of California CEO to Speak at Democratic Convention Host Committee's Health Roundtable in Denver 2Health News:Former U.S. Assistant Surgeon General, Dr. Susan Blumenthal, to Lead Meridian International Center's Global Health Program 2
(Date:10/30/2014)... N.Y. , Oct. 30, 2014  Misonix, Inc. ... device company that designs, manufactures and markets innovative therapeutic ... specialties, announced today that it will report financial results ... November 6, 2014. The Company has scheduled a conference ... 4:30 pm ET to review the results. ...
(Date:10/30/2014)... , Oct. 30, 2014  Zimmer Holdings, Inc. (NYSE: ... the future executive leadership team and organizational structure of ... transaction.  Zimmer also announced that the combined organization will ... be named Zimmer Biomet, with the new brand to ... closing of the merger.  The future leadership team is ...
(Date:10/30/2014)... 30, 2014  The number of retail health clinics ... growing steadily, thanks to drug store chains, according to ... the economic downturn, retail clinic growth had been at ... as the number of retail clinics reached nearly 1,600 ... Clinics Market Overview and 2014 Consumer Survey Results .  ...
Breaking Medicine Technology:Misonix, Inc. To Report First Quarter Fiscal Year 2015 Financial Results On Thursday, November 6, 2014 2Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 2Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 3Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 4Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 5Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 6Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 7Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 8Zimmer Announces Executive Leadership Team and New Name of Combined Company Following Closing 9Report: Drugstore Chains Drive Retail Clinic Growth 2Report: Drugstore Chains Drive Retail Clinic Growth 3
... offered as 1-piece or modular, in regular ... may be customized with handles of choice ... and flush ports. Many standard patterns are ... affect delivery times. , Please Note: ...
... Many special order products are offered ... extra long lengths. The modular instruments may ... other options such as ratchets, insulation and ... from Mediflex stock. Customer specifications may affect ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
Medicine Products: