Navigation Links
Global burden of dengue is triple current estimates

The global burden of dengue infection is more than triple current estimates from the World Health Organization, according to a multinational study published today in the journal 'Nature'.

The research has created the first detailed and up-to-date map of dengue distribution worldwide, enabling researchers to estimate the total numbers of people affected by the virus globally, regionally and nationally. The findings will help to guide efforts in vaccine, drug and vector control strategies.

The study was led by Professor Simon Hay, a Wellcome Trust Senior Research Fellow at the University of Oxford, as part of the International Research Consortium on Dengue Risk Assessment, Management and Surveillance.

Dengue, also known as 'breakbone fever', is a viral infection that is transmitted between humans by mosquitoes. In some people, it causes life-threatening illness.

There are currently no licensed vaccines or specific treatments for dengue, and substantial efforts to control the mosquitoes that transmit the disease have not stopped its rapid emergence and global spread. Until now, little was known about the current distribution of the risk of dengue virus infection and its public health burden around the world.

Dr Samir Bhatt, who led the modelling for the study, says: "Our aim was to take all of the evidence that is currently available on the distribution of dengue worldwide and combine it with the latest in mapping and mathematical modelling to produce the most refined risk maps and burden estimates. We then hope to use this knowledge to help predict the future burden of the disease."

The findings reveal that dengue is ubiquitous throughout the tropics, with local spatial variations in risk influenced strongly by rainfall, temperature and urbanisation. The team estimate that there are 390 million dengue infections across the globe each year, of which 96 million reach any level of clinical or subclinical severity. This is more than triple the WHO's most recent estimates of 50-100 million infections per year.

Professor Simon Hay explains: "We found that climate and population spread were important factors for predicting the current risk of dengue around the world. With globalisation and the constant march of urbanisation, we anticipate that there could be dramatic shifts in the distribution of the disease in the future: the virus may be introduced to areas that previously were not at risk, and those that are currently affected may experience increases in the number of infections.

"We hope that the research will initiate a wider discussion about the significant global impact of this disease."

Of the 96 million apparent infections, Asia bore 70 per cent of the burden. India alone accounted for around one-third of all infections. The results indicate that with 16 million infections, Africa's burden is almost equivalent to that of the Americas and is significantly larger than previously appreciated. The authors suggest that the hidden African dengue burden could be a result of the disease being masked by symptomatically similar illnesses, under-reporting and highly variable treatment-seeking behaviour.

Professor Jeremy Farrar, Director of the Wellcome Trust Vietnam Research Programme and Oxford University Clinical Research Unit Hospital for Tropical Diseases in Vietnam, explains that the map and estimates produced by Hay's group set the benchmark for the disease: "This is the first systematic robust estimate of the extent of dengue. The evidence that we've gathered here will help to maximise the value and cost-effectiveness of public health and clinical efforts, by indicating where limited resources can be targeted for maximum possible impact

With endemic transmission in Asia and the Americas, recent outbreaks in Portugal, the ever-increasing incidence in Africa, and the challenges of making an effective dengue vaccine or controlling the vector, Professor Farrar stresses: "This really does represent a crucial period in the global spread of dengue."

Jimmy Whitworth, Head of International Activities at the Wellcome Trust, said: "Over time, this comprehensive map of global disease burden will also help to demonstrate which control measures are making the biggest difference in reducing the number of people suffering from dengue infection. Without a vaccine or specific treatment options, it's crucial that we understand where best to direct the limited resources available for preventing this resurgent disease."


Contact: Jen Middleton
Wellcome Trust

Related medicine news :

1. AMD Global Telemedicine Reports Increase in International Adoption of Clinical Telemedicine
2. Global Life and Health Insurance Carriers Industry Market Research Report from IBISWorld has Been Updated
3. Global Vision to Host StandardPractice Seminar NYC - A Seminar Series for Digital File Creation
4. HIV self-testing: The key to controlling the global epidemic
5. Global Biopsy Devices Market - New Market Research Report Published by Transparency Market Research
6. CuraLase Global, Inc. Launches a New Website
7. Offers Connecticut Limo Services For Unite For Sight Global Health & Innovative Conference 2013
8. Quorum Review IRB to Present “eConsent and the iPad: a Case Study” at Global ACRP Conference
9. CuraLase Global, Inc. Now Franchising
10. Global Vision Teams with Four Pees to Offer Automated Proofreading Solutions Worldwide
11. WCCT Global Announces Social Media Clinical Study Recruitment Strategy Webinar to be held on April 4th, 2013.
Post Your Comments:
(Date:10/13/2015)... Boulder, Colorado (PRWEB) , ... October 13, 2015 ... ... launched the first high-tech foam roller with 11 hours of vibrating power. Tested ... to reduce recovery time and increase athletic performance. , Mark's background in sporting ...
(Date:10/13/2015)... , ... October 13, 2015 , ... The American Institutes ... college campus health staff caring for students who have experienced sexual assault and other ... the White House during the Violence Against Women Act's 21st anniversary. ...
(Date:10/13/2015)... M.A. (PRWEB) , ... October 13, 2015 , ... Sir ... service to the local Boston chapter of Ronald McDonald House Charities® (RMHC®). This ... that has supported Sir Grout of Greater Boston since its inception. , “We believe ...
(Date:10/13/2015)... ... ... "My friend's son suffers from eczema, and he had a horrible habit ... Platteville, Colo. "I came up with this kit as a way to prevent children ... child from rubbing or scratching his or her face. This protects sensitive skin from ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... anesthesia and pain management services, today announced its partnership with WPC Healthcare ... data from disparate systems and organizes the data into an aggregated data repository ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Oct. 13, 2015 Attracting mid- to large-sized medical ... to growing Baltimore into a major ... by the Maryland Technology Enterprise Institute (Mtech) . ... pieces in place to support innovation hubs and a thriving ... Mtech Baltimore. "This study is important because we believe ...
(Date:10/13/2015)... , Oct. 13, 2015  Graduate students ... care and medical research, will soon have the ... patient care – the drug discovery and development ... ) has collaborated with 10 leaders from academic ... "Making Medicines: The Process of Drug Development."  Lilly ...
(Date:10/13/2015)... SAN FRANCISCO , October 13, 2015 ... expected to reach USD 26.8 billion by 2022, according ... Anesthesia and respiratory devices, owing to their capability to ... expected to witness a substantial growth. --> ... reach USD 26.8 billion by 2022, according to a ...
Breaking Medicine Technology: