Navigation Links
GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer
Date:1/30/2009

slow-growing NHL.(8) Finally, a Phase II study is evaluating ofatumumab plus ICE or DHAP chemotherapy regimen in relapsed/refractory diffuse large B-cell lymphoma (DLBCL).

About ofatumumab

Ofatumumab is an investigational monoclonal antibody that targets a membrane-proximal (close to the cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B-cells.(9) This epitope is different from the binding sites targeted by other CD20 antibodies currently available.(10) The CD20 molecule is a key target in CLL therapy because it is highly expressed in most B-cell malignancies.(11)

Ofatumumab is being developed to treat chronic lymphocytic leukemia, non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, rheumatoid arthritis, and relapsing-remitting multiple sclerosis under a co-development and commercialization agreement between Genmab and GlaxoSmithKline. It is not yet approved in any country.

The companies intend to submit an application for marketing approval in Europe shortly.

About CLL

CLL is the most common adult leukemia(1,2) and one of the most common malignant lymphoid diseases.(12) Based on 2007 worldwide estimates, leukemia accounted for more than 330,000 new cases and more than 245,000 deaths.(13)

CLL cells are malignant B-cells(14) that have low surface expression levels of CD20 molecules.(9) B-cells normally protect the body from invading pathogens by developing into plasma cells, which make antibodies. These antibodies directly inactivate pathogens or attach to pathogens to prepare them for destruction by other white blood cells.(14,15)

GlaxoSmithKline (GSK)

GlaxoSmithKline - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better, an
'/>"/>

SOURCE GlaxoSmithKline
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. GlaxoSmithKlines Drug Will Become New Clinical Gold Standard by 2012 for the Treatment of Relapsed/Refractory CLL
2. GlaxoSmithKline Awards Ten Area Healthcare Nonprofits with $40,000 Each in Funding
3. GlaxoSmithKline and Dynavax Announce Worldwide Strategic Alliance : – Developing First-in-Class Endosomal TLR Inhibitors for Autoimmune and Inflammatory Diseases –
4. GlaxoSmithKline Statement on FDA Advisory Committee Vote on Use of Asthma Medicines Containing Long-Acting Beta-Agonists
5. GlaxoSmithKline and The Carter Center Reaffirm Commitment to Global Public Health with Expansion of LF Program
6. GlaxoSmithKline to Acquire the Leading Dry Mouth Brand, Biotene
7. AUDIO from Medialink and GlaxoSmithKline: Give Kids A Boost For Their Health!
8. GlaxoSmithKline Acquires Sirtris Pharmaceuticals, Inc., a World Leader in Sirtuin Research and Development
9. Amira Pharmaceuticals Achieves Milestones in FLAP Inhibitor Program With GlaxoSmithKline
10. Emerging Combination Therapies, Including Drugs from Novartis/Schering-Plough and GlaxoSmithKline/Theravance Will Drive the COPD Drug Market to More Than $11 Billion in 2017
11. Video: GlaxoSmithKline Consumer Healthcare Offers Free Nicotine Lozenges for All Certified Pilots and Air Traffic Controllers to Help Them Safely Quit Smoking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Steven Reinberg HealthDay Reporter ... intended to help with weight loss by blocking a certain ... in a trial among obese patients. Using electric impulses ... and stomach, researchers hoped to suppress feelings of hunger. And, ... "A device that safely blocks the nerve that connects the ...
(Date:9/2/2014)... Reinberg HealthDay Reporter ... Ebola outbreak continues to overwhelm health-care workers in three ... and the United Nations called on Tuesday for a ... the often-fatal virus. Dr. Thomas Frieden, director of ... that without a greater global commitment in resources -- ...
(Date:9/2/2014)... on sleep apnea, tonsillectomies, hearing loss, head and ... presented in Orlando, FL, September 21-24, at the ... American Academy of OtolaryngologyHead and Neck Surgery Foundation ... throat, head and neck physicians in the world. ... were released today, and are available online at ...
(Date:9/2/2014)... September 02, 2014 When weather conditions are ... or night, leaving behind a path of destruction. In fact, ... an average of 1,253 tornadoes per year. Rainbow International offers ... case a tornado strikes., , Select a ... room in your home with no windows to stay during ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Ticket Down ... The first week in September will be an exciting ... from Brazil, Colombia, Mexico, Chile, Ecuador and Bolivia will battle ... matches will take place between September 5th - September 9th: ... on Tuesday, September 9th , Mexico vs. Chile Tickets ...
Breaking Medicine News(10 mins):Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 2Health News:Nerve Blocking Procedure Fails to Impress in Weight Loss Study 3Health News:More Global Help Needed to Fight Ebola Outbreak 2Health News:More Global Help Needed to Fight Ebola Outbreak 3Health News:Act Quickly in Case of Tornado: Rainbow International® Offers Tips on How to Be Prepared for a Tornado 2Health News:Ticket Down Substantially Slashes Ticket Prices on Brazil vs. Ecuador Tickets, Brazil vs. Colombia Tickets, Mexico vs. Chile Tickets and Mexico vs. Bolivia Tickets 2Health News:Ticket Down Substantially Slashes Ticket Prices on Brazil vs. Ecuador Tickets, Brazil vs. Colombia Tickets, Mexico vs. Chile Tickets and Mexico vs. Bolivia Tickets 3
... Derma Sciences, Inc. (OTC ... products, announced today that it has begun shipping BIOGUARD(TM) ... that it has been awarded reimbursement codes for the ... BIOGUARD will offer surgeons, wound care clinicians, infection ...
... A study released earlier this month by Harvard Law ... found that medical bills are involved in more than ... six years ago. Additionally, more than 75 percent of these ... out-of-pocket expenses. In the wake of these startling increases and ...
... community with the help of donors , , ROYAL ... ), a comprehensive nonprofit community resource that creates solutions ... the newly-constructed Autism Center at its 4410 W. 13 Mile ... advocates and families as well as local leaders and media ...
... Continues to Accelerate , , SAN FRANCISCO, June 23 ... today announced that it was issued patent number 7,540,615 by ... owns or licenses 90 US and foreign patents covering inventions ... Posit Science develops and distributes brain fitness software demonstrated to ...
... ... found that there are significant differences in the way our brains function depending on whether ... ... owl?", , ,Scientists at the University of Alberta have found that there are significant differences ...
... HONG KONG, June 23 /PRNewswire-Asia/ -- Wan (Corporate Services) ... further statement,to clarify the NITRITE level of Perrier. , ... Council Findings , We strongly believe the Consumer ... submit that the figure 0.4 mg/L of Nitrite in Perrier is,not correct. ...
Cached Medicine News:Health News:Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings 2Health News:Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings 3Health News:Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings 4Health News:The Wellness Community Launches National Education Program Addressing the Cost of Cancer Care 2Health News:The Wellness Community Launches National Education Program Addressing the Cost of Cancer Care 3Health News:Judson Center Celebrates Grand Opening of its New Autism Center 2Health News:90 Brain Fitness Patents for Posit Science 2Health News:Morning People and Night Owls Show Different Brain Function: University of Alberta Study 2Health News:Perrier Clarifies the NITRITE Level in Consumer Council Findings 2
(Date:9/2/2014)... 2, 2014 According to the ... Pre-packed, Analytical, Preparative), by Material (Metal, Glass, Plastic), by ... Forecast to 2018", published by MarketsandMarkets, the Chiral Chromatography ... is poised to grow at a CAGR of 5.2% ... Browse 90 market data tables and 15 ...
(Date:9/2/2014)... , September 2, 2014 , ... patients, quality of life and treatment satisfaction [ ... ]        ... 2014, 02 September 2014, Barcelona, Spain ... the PREvention oF thromboembolic events-European Registry in Atrial Fibrillation ...
(Date:9/2/2014)... and ,S-HERTOGENBOSCH, the Netherlands , ... ) has expanded its North American operations through its ... providing warehousing, fulfillment and order to cash services for ... , utilizing our global ERP platform. Building ... our customers in Europe with ...
Breaking Medicine Technology:Chiral Chromatography Column Market Worth $87.8 Million by 2018 2Chiral Chromatography Column Market Worth $87.8 Million by 2018 3Chiral Chromatography Column Market Worth $87.8 Million by 2018 4One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 2One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 3One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 4One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 5One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 6One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 7One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 8HealthLink Europe opens North American medical warehouse operation 2
... Medical Device Media Group today announced its leading brands, ... ) magazine, MPMN ( Medical Product Manufacturing ... virtual event focusing on progressive trends in the design ... device manufacturers. (Logo:   http://photos.prnewswire.com/prnh/20101214/LA16070LOGO ) ...
... WomanCare Global is pleased to announce that it ... Screen in New York,s Times Square.  The purpose of ... 215 million women worldwide that do not have access ... "Women are the cornerstone of every ...
Cached Medicine Technology:MD+DI, MPMN, and OrthoTec Announce Virtual Event Dedicated to Cutting-Edge Trends in Implantable Medical Devices 2MD+DI, MPMN, and OrthoTec Announce Virtual Event Dedicated to Cutting-Edge Trends in Implantable Medical Devices 3WomanCare Global Highlights the Unmet Need of 215 Million Women on Famous CBS Super Screen in Times Square 2
... These dual pressure sensor catheters ... injection, slow-speed injection/guide wire, or ... SPC-784A for high-speed injection has ... openings and an open-end pigtail ...
... pressure intravascular catheters provide a simple, ... measuring pressures in the heart or ... catheters are ideal for high fidelity ... size from 2 to 7 French ...
... Intravascular Mikro-Tip Pressure Catheters; Millar manufactures ... pressure sensor catheters for simultaneous high ... suitable for measuring pressure gradients across ... a vascular stenosis. The catheters are ...
... pressure intravascular catheters provide a simple, ... measuring pressures in the heart or ... catheters are ideal for high fidelity ... size from 2 to 7 French ...
Medicine Products: