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GlaxoSmithKline Presents Innovative Neuroscience Pipeline
Date:12/13/2007

etabolic-related effects, such as weight gain and blood lipid increases, which are common side effects of antipsychotic treatments. In one study, patients receiving 60mg daily of '812 experienced a decrease of 1.0kg in body weight, which was a statistically significant change compared to patients receiving placebo or olanzapine, whose body weight increased by 0.9kg and 2.2kg respectively. In addition, patients receiving '812 did not show an increase in triglycerides or cholesterol levels.

The development program for '812 continues with phase IIb trials, which are expected to demonstrate benefits versus two commonly used treatments for schizophrenia. These trials are expected to start in 2008.

742457 - A novel treatment to delay the symptoms of Alzheimer's disease:

Alzheimer's disease is a devastating neurological condition, with significant consequences on the quality of life for sufferers and their care givers. GSK has a broad program of research ongoing in Alzheimer's disease, including 742457, a novel treatment that selectively targets the 5HT6 receptors concentrated within the brain. These receptors are associated with learning and memory. Currently available treatments, such as cholinesterase inhibitors, are not brain specific and alter the cholinergic system throughout the body leading to possible side effects, particularly gastrointestinal side effects.

Results from a phase II placebo-controlled dose-ranging study in 371 patients demonstrated that over a 24-week treatment period, patients receiving 35mg doses of '457 showed statistically significant improvements in global function compared to placebo as measured by the CIBIC+. The CIBIC+ is a clinician-rated scale which assesses global improvement, including input from patients' care givers. All doses of '457 appeared generally well tolerated, with a low overall incidence of adverse events.

Another phase II trial comparing 15-35mg of '457, and 5-10mg of donepezil, a commonly
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SOURCE GlaxoSmithKline
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