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GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.
Date:11/26/2007

To 100 To 130

(10-year risk >20%) (100-129: drug optional)

++

2+ Risk factors <130 Greater Than or Equal 10-year risk 10-20%:

(10 year risk Less To 130 Greater Than or Equal

Than or Equal To 20%) To 130

10-year risk <10%:

Greater Than or Equal

To 160

0-1 Risk factor+++ <160 Greater Than or Equal Greater Than or Equal

To 160 To 190

(160-189: LDL-lowering

drug optional)

+ CHD, coronary heart disease

++ Some authorities recommend use of LDL-lowering drugs in this category if an LDL-C level of <100 mg/dL cannot be achieved by therapeutic lifestyle changes. Others prefer use of drugs that primarily modify triglycerides and HDL-C, e.g., nicotinic acid or fibrate. Clinical judgment also may call for deferring drug therapy in this subcategory.

+++ Almost all people with 0-1 risk factor have a 10-year risk <10%; thus, 10-year risk assessment in people with 0-1 risk factor is not necessary.

After the LDL-C goal has been achieved, if the TG is still Greater Than or Equal To 200 mg/dL, non-HDL-C (total-C minus HDL-C) becomes a secondary target of therapy. Non-HDL-C goals are set 30 mg/dL higher than LDL-C goals for each risk category.

At the time of hospitalization for an acute coronary event, consideration can be given to initiating drug therapy at discharge if the LDL-C is Greater Than or Equal To 130 mg/dL (see NCEP Guidelines above).

Since the goa
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SOURCE GlaxoSmithKline
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