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GlaxoSmithKline Files for FDA Approval of PROMACTA(TM) (eltrombopag) to be the First Oral Platelet Growth Factor for Rare Blood Disorder
Date:12/20/2007

m Act of 1995, the company cautions investors that any forward-looking statements or projections made by the company, including those made in this Announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Factors that may affect the Group's operations are described under 'Risk Factors' in the 'Business Review' in the company's Annual Report on Form 20-F for 2006.

Note to Editors

PROMACTA(TM) is the proposed registered trademark of the GlaxoSmithKline group of companies to be used in the United States.

To access the latest GSK news, visit http://us.gsk.com/.

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US Media inquiries: Jeff McLaughlin 1 919 483 2839

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References:

(1) National Heart, Lung, and Blood Institute. Diseases and Conditions Index. http://www.nhlbi.nih.gov/health/dci/Diseases/Itp/ITP_WhatIs.html. Accessed November 12, 2007.

(2) Cines DB, Blanchette V. Idiopathic thrombocytopenic purpura. N Engl J Med. 2002;364: 995-1008.

(3) Data on File, GlaxoSmithKline.

(4) Bussel, J., Cheng, G., Saleh, M., et al. Eltrombopag, an Oral Platelet Growth Factor, for the Treatment of Patients with Chronic Idiopathic Thrombocytopenic Purpura. N Engl J Med. 2007; 357(22): 2237-2247.

(5) Cines DB, McMillan R. Management of adult idiopathic thrombocytopenic purpura. Annu Rev Med. 2005;56:425-442.


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