Navigation Links
Glaucoma drug can cause droopy eyelids
Date:5/21/2013

BOSTON (May 21, 2013) Prostaglandin analogues (PGAs), drugs which lower intraocular pressure, are often the first line of treatment for people with glaucoma, but their use is not without risks. PGAs have long been associated with blurred vision, dryness, changes in eye color and other side effects. Now a new study has found that these drugs also cause upper and lower eyelid drooping and other issues that can interfere with vision. The findings are described in PLOS ONE.

Researchers from the Massachusetts Eye and Ear performed multivariable analysis accounting for age, body mass index (BMI), medical conditions, and other glaucoma medications that could confound the potential association between PGAs and the periocular changes in a large, cross-sectional study that assesses the ocular anatomy of glaucoma patients with masked reviewers using a validated instrument.

"We identified important side effects of PGAs, namely the loss of periorbital fat in the upper and lower lid and the presence of ptosis," said senior author Louis R. Pasquale, M.D., F.A.R.V.O., director of the Glaucoma Service at Mass. Eye and Ear and associate professor of ophthalmology at Harvard Medical School. "The loss of periorbital fat was previously described by us in a small series of unilateral PGA users. In fact, those observations did ultimately lead to a change in drug labeling. These new findings could change labeling for the PGAs, as the upper lid ptosis could aggravate pre-existing visual field loss."

Researchers performed this study to confirm whether prostaglandin-associated periorbitopathy (PAP) is clearly associated with PGA application among bilateral users using a validated grading scheme applied by masked observers and confirmed by clinical examination. They performed multivariable analyses to assess whether PAP was independently associated with PGA use or if it was the result of confounding features such as age, ethnicity, BMI or use of other classes of glaucoma medications. They studied 343 patients (186 females and 157 males) over the course of seven months in 2011.

The study showed associations between current bilateral PGA use and deepened upper eyelid sulci, hollowing of the inferior periorbital fat pads, upper eyelid ptosis with levator muscle dysfunction, and lower lid retraction. Their work demonstrated that PAP is fairly common and consists of findings that extend beyond deepening of the upper eyelid sulcus. A full description of the methods and results are in the paper.

"Because PGAs are a first line of treatment for glaucoma, these results provide physicians with one reason to reconsider when they should be added in new patients, particularly those where the aim is to prevent glaucoma such as in ocular hypertension patients or glaucoma suspects," Dr. Pasquale said.

Mamta Shah, M.D., a medical student from Boston University School of Medicine, led the research.


'/>"/>

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
617-573-4170
Massachusetts Eye and Ear Infirmary
Source:Eurekalert

Related medicine news :

1. New study pinpoints biochemical mechanism underlying fibrosis following glaucoma surgery
2. Best Glaucoma Treatments Still a Puzzle, Task Force Reports
3. The Boston Eye Group Implants First Intraocular Pressure Transducer for Glaucoma Monitoring
4. Atlanta LASIK Surgery Center Publishes Response to Correlation Between Coffee Consumption and Glaucoma
5. Researchers identify an early predictor for glaucoma
6. U.S. Glaucoma Cases Jump 22 Percent Over Decade: Report
7. Glaucoma study could inspire e-reader apps
8. Rapid eye movements significantly delayed in people with glaucoma
9. Micro-Stents May Hold Potential to Treat Glaucoma
10. Drivers Glaucoma May Boost Accident Risk
11. Glaucoma-related vision loss may increase risk for auto accidents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2017)... Chicago, IL (PRWEB) , ... May 27, 2017 , ... ... dentistry. , Regardless of the talent of your dental team at presenting treatment, there ... Dental professionals invest a lot of time and money on best practices when it ...
(Date:5/26/2017)... ... May 26, 2017 , ... Leading CEOs from ... May 30th and 31st at The Four Seasons Hotel Boston. , The ... life sciences, offering exclusive access to key decision makers who influence deal making ...
(Date:5/26/2017)... ... 26, 2017 , ... Boar’s Head Brand®, one of the ... Day entertaining that are sure to satisfy your guests’ flavor cravings, while adding ... cheeses featured in these refreshingly balanced recipes are packed with flavor, creating the ...
(Date:5/26/2017)... ... ... Silver Birch of Hammond, a new assisted lifestyle community, has welcomed its ... land at 5620 Sohl Avenue in Hammond, serves older adults who need some help ... one-bedroom apartments. Each of the private apartments at Silver Birch features a kitchenette, spacious ...
(Date:5/26/2017)... Colorado (PRWEB) , ... May 26, 2017 , ... ... will be this year’s recipient of proceeds from its 14th Annual Clays for ... 46700 E. County Road 30, Bennett, Colorado. , As part of BluSky’s ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... May 5, 2017   Provista , a proven leader ... 200,000 customers, today announced Jim Cunniff as the ... executive and business experience to Provista, including most recently serving ... California . He assumed his new role ... a great fit for Provista," says Jody Hatcher , ...
(Date:5/6/2017)... , May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: ... approximately 100,000 square feet to its Welch Allyn campus. ... its commitment to bring more than 100 new jobs ... Welch Allyn has maintained a significant presence for more ... these new positions, a large portion of which will ...
(Date:5/4/2017)... MEMPHIS, Tenn. , May 4, 2017 /PRNewswire/ ... of Infection Control, Ultraviolet-C light as ... demonstrated Tru-D SmartUVC,s ability to reduce bioburden on ... influenced bioburden reduction on high-touch, complex medical equipment ... in surgical infections. "This study further ...
Breaking Medicine Technology: