Navigation Links
Glaucoma Begins in Mid-Brain, Not in Eye, Research Shows
Date:3/3/2010

Animal study shows degeneration occurring in reverse order than commonly believed

WEDNESDAY, March 3 (HealthDay News) -- Early signs of glaucoma can be detected in the brain, according to a new study that may trigger a major change in how the disease is treated.

It has long been believed that glaucoma -- the leading cause of blindness in the United States -- results from pressure within the eye that damages the retina and optic nerve, so treatments have focused on reducing pressure within the eye. However, this new study suggests that glaucoma is a central nervous system disease that requires different treatment approaches.

"This is a paradigm shift in how we think about the disease," study author David Calkins, director of research at the Vanderbilt Eye Institute, said in a news release from the Vanderbilt University Medical Center. "This will have global implications. This information opens up an entirely new domain of nerve-derived therapeutics."

In research with lab animals, Calkins and his team found that a very early mechanism of glaucoma-related vision loss involves deterioration of communication between the optic nerve and the mid-brain, which handles information about sensory input such as sound, heat, cold, pain and pressure.

"If you followed the disease long enough, eventually the optic nerve, then the retina, show signs of degeneration," Calkins explained. "So the degeneration works in reverse order. It starts in the brain and works its way back to the retina so that in the very latest stages of the disease, the earliest structures, the one nearest the eye, are the last to go."

The study findings were released online March 1 in advance of publication in an upcoming print issue of the journal Proceedings of the National Academy of Sciences.

More information

The U.S. National Eye Institute has more about glaucoma.



-- Robert Preidt



SOURCE: Vanderbilt University Medical Center, news release, March 1, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
2. Glaucoma surgery in the blink of an eye
3. Glaucoma surgery in the blink of an eye
4. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
5. Looking at Glaucoma as a Systemic Disease
6. Cost of glaucoma medications may impact treatment
7. January is National Glaucoma Awareness Month
8. Upcoming meeting will explore new technologies for glaucoma clinical drug trials
9. Dr. Welsh Self-Test Diagnoses Glaucoma, the Leading Cause of Preventable- Blindness
10. Mayor Bloomberg Declares March 6, 2008 World Glaucoma Day in New York City
11. Glaucoma May Boost Cardiovascular Death Risk in Blacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
Breaking Medicine Technology: