Navigation Links
Glaucoma Begins in Mid-Brain, Not in Eye, Research Shows
Date:3/3/2010

Animal study shows degeneration occurring in reverse order than commonly believed

WEDNESDAY, March 3 (HealthDay News) -- Early signs of glaucoma can be detected in the brain, according to a new study that may trigger a major change in how the disease is treated.

It has long been believed that glaucoma -- the leading cause of blindness in the United States -- results from pressure within the eye that damages the retina and optic nerve, so treatments have focused on reducing pressure within the eye. However, this new study suggests that glaucoma is a central nervous system disease that requires different treatment approaches.

"This is a paradigm shift in how we think about the disease," study author David Calkins, director of research at the Vanderbilt Eye Institute, said in a news release from the Vanderbilt University Medical Center. "This will have global implications. This information opens up an entirely new domain of nerve-derived therapeutics."

In research with lab animals, Calkins and his team found that a very early mechanism of glaucoma-related vision loss involves deterioration of communication between the optic nerve and the mid-brain, which handles information about sensory input such as sound, heat, cold, pain and pressure.

"If you followed the disease long enough, eventually the optic nerve, then the retina, show signs of degeneration," Calkins explained. "So the degeneration works in reverse order. It starts in the brain and works its way back to the retina so that in the very latest stages of the disease, the earliest structures, the one nearest the eye, are the last to go."

The study findings were released online March 1 in advance of publication in an upcoming print issue of the journal Proceedings of the National Academy of Sciences.

More information

The U.S. National Eye Institute has more about glaucoma.



-- Robert Preidt



SOURCE: Vanderbilt University Medical Center, news release, March 1, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
2. Glaucoma surgery in the blink of an eye
3. Glaucoma surgery in the blink of an eye
4. Chair of U.S. Preventive Services Task Force Pledges to Recommend Re-evaluation of Recent Glaucoma Findings
5. Looking at Glaucoma as a Systemic Disease
6. Cost of glaucoma medications may impact treatment
7. January is National Glaucoma Awareness Month
8. Upcoming meeting will explore new technologies for glaucoma clinical drug trials
9. Dr. Welsh Self-Test Diagnoses Glaucoma, the Leading Cause of Preventable- Blindness
10. Mayor Bloomberg Declares March 6, 2008 World Glaucoma Day in New York City
11. Glaucoma May Boost Cardiovascular Death Risk in Blacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... 2017 , ... On Sunday, September 24, hundreds will gather at Flo Jo ... considered the fastest woman of all time. Flo Jo passed away from complications ... the National Anthem. Mary was a contestant on the 2012 season of America’s ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... assembles Passive House buildings, and Richard Pedranti Architect (RPA), a full-service ... from the strategic partner’s Solsken Line of Model Homes . Independently, Ecocor ...
(Date:9/22/2017)... ... September 22, 2017 , ... SABRE is ... Sweepstakes.,  , Molli C., a graduate student from Sonora, California, who will begin ... at St. Thomas University in Miami, Florida, was selected from a pool of ...
(Date:9/22/2017)... ... ... “Cursed with a Curse: The Truth about Tithing”: a ... when breaking free from this misconception. “Cursed with a Curse: The Truth about ... Christian Faith Publishing, Lysa M. Harrison’s new book is a powerful and thought-provoking ...
(Date:9/22/2017)... ... 2017 , ... "Success Files," a short- and long-form documentary ... a disease estimated to affect the lives of more than 5 million Americans ... a leading voice in the fight for cure and research into the disease, ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... -- As the latest Obamacare repeal effort moves is debated, ... and Lindsey Graham (R-SC) medical device market ... is in an odd place.  The industry wants repeal ... on medical device sales passed along with the Affordable ... visits and hospital customers with the funding to invest ...
(Date:9/18/2017)... , Sept. 18, 2017 EpiVax, ... of bioinformatics and immune engineering, today announced ... influenza A (H7N9) vaccine. ... to seasonal influenza and presents a challenge ... prior exposure to be effective. Using state-of-the-art ...
(Date:9/9/2017)... Sept. 8, 2017 ... MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September 18 th ... offering free MRI brain scans to the public.Where:  ... parked at 501 K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, ...
Breaking Medicine Technology: