Navigation Links
Gladstone scientists identify target that may reduce complications of obesity
Date:2/3/2010

SAN FRANCISCO, CA February 2, 2010 -- Although obesity is a risk factor for diabetes and coronary heart disease worldwide, only some obese individuals go on to develop these metabolic complications, while others are relatively protected. Defining these protective factors could help scientists prevent disease in the wider population.

To this end, a research team at the Gladstone Institute of Cardiovascular Disease, led by Suneil Koliwad, MD, PhD, recently added new details that link obesity to diabetes and heart disease.

When individuals become obese from overeating, cells called adipocytes located in the fat tissue fill up with dietary fats and begin to die. Immune cells called macrophages move out of the blood stream and into this tissue, where they accumulate around dying adipocytes. As the macrophages work to clear away the dead cells, they are exposed to large amounts of dietary fat that can result in unwanted consequences. Exposure to saturated fats, in particular, causes the macrophages to enter an inflammatory state. In this state, the macrophages secrete cytokines, such as tumor necrosis factor (TNF) alpha, that encourage the development of insulin resistance, diabetes, and heart disease.

The Gladstone team hypothesized that enhancing the capacity of macrophages to store dietary fats might alter this process. To do this, they focused on an enzyme called DGAT1, which makes triglycerides from dietary fats for storage as cellular energy reserves.

They examined a transgenic strain of mice (aP2-Dgat1) that make large amounts of DGAT1 in both adipocytes and macrophages. On a high-fat diet, these mice became obese, but the macrophages in their fat tissue did not undergo inflammatory activation, and the mice were protected from developing systemic inflammation, insulin resistance, and fatty livers, all problems that were profound in the control mice.

Even more interesting was the team's finding that the protectio
'/>"/>

Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gladstone scientists identify single microRNA that controls blood vessel development
2. Gladstone scientists identify role of fatty acids in Alzheimers disease
3. HBO, Gladstone Institute of Neurological Disease, UC Davis Alzheimers Disease Center, UCSF Memory & Aging Center and The Alzheimers Association, No. Cal. Present an Advance Screening of THE ALZHEIMERS PROJECT: Momentum In Science
4. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
5. Scientists Probe Sepsis Deadly Secrets
6. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
7. Scientists Develop Natural Protection for Stored Foods
8. Scientists detect presence of marburg virus in african fruit bats
9. Scientists Spot Brains Free Will Center
10. Scientists ID Likely Culprit in Popcorn Lung
11. Scientists explain how insulin secreting cells maintain their glucose sensitivity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... July 30, 2015 , ... As more hospitals across ... of recruiting patients becomes a serious challenge. Because of growing competition, it is ... within the local community. , The team at Wound Care Advantage ...
(Date:7/30/2015)... ... July 30, 2015 , ... OSF Healthcare System has been ... Most Wired Survey conducted by Hospitals & Health Networks. This marks the fourth consecutive ... by The Sisters of the Third Order of St. Francis . , Health ...
(Date:7/30/2015)... ... ... a healthy head of hair and a feeling of confidence is a powerful one for ... a devastating impact on the daily life of a person. From increased anxiety to ... loss are not to be taken lightly. , The skilled staff at Parsa Mohebi Hair ...
(Date:7/30/2015)... ... July 30, 2015 , ... Zaca Life has created ... With no water needed, the refreshing berry-flavored tablets are the perfect travel companion. ... natural ingredients that may help with body detoxification, protection and hydration,” said Mark ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... ... TikiLIVE, has worked to protect victims in San Diego, California’s Gaslamp Quarter Plaza ... used by Gaslamp Quarter Plaza actively monitor the area for any suspicious activity. ...
Breaking Medicine News(10 mins):Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 2Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 3Health News:WCA Offers Shockwave; The Marketing Module for Hospital Wound Care Programs 4Health News:OSF HealthCare Named One of the Most Wired Systems 2Health News:OSF HealthCare Named One of the Most Wired Systems 3Health News:New Study Shows the Link between Hair Restoration and Healthy Self-Image 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 3Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 4Health News:Eyepartner Software Helps Victims in Gaslamp Quarter Plaza 2Health News:Eyepartner Software Helps Victims in Gaslamp Quarter Plaza 3
... United States, the management of glaucoma costs about $2.5 ... costs, glaucoma medications account for an estimated 38% to ... the January 2008 issue of the American Journal of ... Science Center College of Medicine, Temple, Texas; analyzed the ...
... Advice for Doctors About Low-Fat, Low-Carb Restricted Diets ... The American,Diabetes Association (ADA) today issued its ... treat people with diabetes,using the most current evidence ... in the Medical Nutrition Therapy,section dealing with weight ...
... Arcade for Kids, Teens, and Adult Gamers --, ... ft. Mega-Center officially opened for workouts on December 17, ... off Cincinnati-Dayton,Road & I-75 next to Wal-Mart. A month ... a silent auction on Saturday, January,19th from 5pm-8pm to ...
... more likely to broach the topic with patients than ... (HealthDay News) -- Many doctors avoid issues of spirituality ... true for most psychiatrists, a new study finds. , ... said it,s always or usually appropriate to ask patients ...
... Dec. 27 Eclipsys Corporation(R),(Nasdaq: ECLP ), ... in the 2008 JPMorgan Healthcare Conference taking place ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050209/FLW006LOGO ), Eclipsys ... January,8th at 3:00 p.m. Pacific time. To access ...
... 27 The dental group that operates the,Park ... today,that it has settled litigation with its administrative ... Minnesota subsidiary,PDHC, Ltd., On December 14, 2007, ... known as PDG, P.A., and Dental Specialists of ...
Cached Medicine News:Health News:Cost of glaucoma medications may impact treatment 2Health News:ADA Issues New Clinical Practice Recommendations 2Health News:ADA Issues New Clinical Practice Recommendations 3Health News:Fitworks West Chester Mega-Center Now Open 2Health News:Fitworks West Chester Mega-Center Now Open 3Health News:Most Psychiatrists Open to Discussing Spiritual Concerns 2Health News:Most Psychiatrists Open to Discussing Spiritual Concerns 3Health News:Eclipsys to Present at JPMorgan Healthcare Conference 2Health News:Eclipsys to Present at JPMorgan Healthcare Conference 3Health News:Park Dental Doctor Group Settles Litigation With Service Provider 2
(Date:7/30/2015)...  Medimetriks Pharmaceuticals, Inc. announced today that its ... study for Ozenoxacin, a novel bactericidal non-fluorinated quinolone ... U.S. rights to Ozenoxacin 1% cream.  ... with an emphasis on U.S. patients, involved 412 ... older with a clinical diagnosis of bullous or ...
(Date:7/30/2015)... , July 30, 2015 Vermillion, ... on gynecologic disease, announced today it will ... after the market close on Thursday, August ... call and webcast at 4:30pm Eastern.Conference Call ... at 4:30pm Eastern/1:30pm Pacific  Domestic: ...
(Date:7/30/2015)... , July 30, 2015  Big Cloud Analytics, ... analytics technology, announces it is working with Intel ... for the new Lockheed Martin Healthcare Technology Alliance. ... health information technology providers, medical technology companies and ... and innovation to improve care in rapidly evolving ...
Breaking Medicine Technology:Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3Big Cloud Analytics Develop Internet of Things (IoT) Solutions with Intel Supporting Launch of Lockheed Martin Healthcare Technology Alliance 2Big Cloud Analytics Develop Internet of Things (IoT) Solutions with Intel Supporting Launch of Lockheed Martin Healthcare Technology Alliance 3
Quantitative determination of Fibrinogen by STA Analyzers (Clauss Method). Freeze-dried human thrombin (~100NIH units/mL) with heparin inhibitor and calcium....
Determination of Prothrombin Time (PT) by STA Analyzers (ISI~1.3).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
The ALB method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of albumin in serum...
The PHOS method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of phosphorus in serum....
Medicine Products: