Navigation Links
Gladstone scientists develop technique to decipher the dormant AIDS virus concealed in cells
Date:9/11/2012

SAN FRANCISCO, CASeptember 11, 2012Scientists at the Gladstone Institutes have gotten us one step closer to understanding and overcoming one of the least-understood mechanisms of HIV infectionby devising a method to precisely track the life cycle of individual cells infected with HIV, the virus that causes AIDS.

In a paper being published online today in Lab on a Chip, the laboratory of Gladstone Investigator Leor Weinberger, PhD, announced the development of a device that can pinpoint and track HIV inside CD4 T cellsthe type of white blood cell that the AIDS virus targets. This development is particularly important for understanding "HIV latency," a state in which the virus goes dormant after the patient begins standard antiretroviral treatment. Current antiretroviral drugs do not kill HIVthey only keep it at baymeaning that those with HIV must continue a lifetime of drug treatment so as not to develop AIDS. If they discontinue the drugs, the latent virus "wakes up" within just a few weeks and begins an onslaught against the body's immune system.

The breakthrough comes as the AIDS-researcher community is beginning to speak publicly about the possibility of curing HIV/AIDS. Understandingand consequently interruptingHIV latency is a key element in the effort to discover a cure for this devastating disease.

"HIV latency is perhaps the single greatest obstacle to eradicating HIV/AIDS in the 34 million people who live with the disease worldwide," said Dr. Weinberger, who is also an associate professor of biochemistry and biophysics at the University of California, San Francisco (UCSF), with which Gladstone is affiliated. "Existing techniques that try to uncover the cellular and viral mechanisms behind HIV latency are inefficient at studying very rare cellsand cells housing the latent HIV virus are one-in-a-million. Our technique presents a clear path towards understanding how HIV latency is regulated within a single cell, by tr
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Gladstones Lennart Mucke receives Lifetime Achievement Award from the Alzheimers Association
2. Reconstructed 1918 influenza virus has yielded key insights, scientists say
3. Scientists put a pox on dog cancer
4. MBL and Stanford scientists receive 2012 Lasker Award for Basic Medical Research
5. Scientists Inch Closer to Genetic Blueprint of Diseases
6. Scientists Find Links Among Parkinsons, Cancer and Family History
7. Danish scientists solve old blood mystery
8. First validated method for analyzing flavanols and procyanidins in cocoa products could help scientists and the industry in standardized reporting
9. Scientists ID Happy Gene in Women
10. NIH scientists map first steps in flu antibody development
11. Scientists to design drug for chronic pain
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gladstone scientists develop technique to decipher the dormant AIDS virus concealed in cells
(Date:7/31/2015)... ... 2015 , ... New Energy Works Timberframers invites the public to join their ... 2015 from 9am – 12pm. Timber frame raisings are special, celebrating both ... as the culmination of months of effort, planning, fundraising, and dreaming takes shape. ...
(Date:7/31/2015)... ... July 31, 2015 , ... An article entitled ... talked about a woman’s unfortunate experience having cosmetic skin procedures done by a ... resulted in blistering, swelling, bruising, and pain. This woman’s experience is only one ...
(Date:7/31/2015)... ... July 31, 2015 , ... In the most recent ... District Court in the Northern District of Illinois, Androgel testosterone attorneys report that a ... a docket entry was made recording the minutes of the status conference, which was ...
(Date:7/31/2015)... ... July 31, 2015 , ... India Network Foundation sponsors visitor ... study or family visit for the past 25 years. As India Network offers coverage ... to travel and spend time with their children and grand children. India Network ...
(Date:7/31/2015)... ... 31, 2015 , ... David Gilpin, M.D., a board certified ... Nashville area sinus sufferers about the benefits of Balloon Sinuplasty. , ... is a good candidate for Balloon Sinuplasty. The questionnaire asks questions about symptoms ...
Breaking Medicine News(10 mins):Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 2Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 3Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 2Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 3Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 2Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 3Health News:Testosterone Lawsuit News: Androgel Lawsuit Conference Held 4Health News:India Network Visitor Health Insurance Announces Completion of Food Grains Distribution to Godavari Pushkaram Visitors, Andhra Pradesh, India 2Health News:India Network Visitor Health Insurance Announces Completion of Food Grains Distribution to Godavari Pushkaram Visitors, Andhra Pradesh, India 3Health News:Nashville Otolaryngologist Dr. David Gilpin Launches Balloon Sinuplasty Website 2Health News:Nashville Otolaryngologist Dr. David Gilpin Launches Balloon Sinuplasty Website 3
... Wake Forest University School of Medicine were expecting a ... a semi-conscious,// vomiting “patient” was rolled into the lecture ... the case. ,“SimMan?,” a reproduction of an ... simulated patient makes realistic heart, lung, and bowel sounds ...
... a government AIDS awareness campaign in Swaziland, a country ... feel it suggests that people living with the disease are ... text messages like 'Let's have a quickie, my husband's not ... in the 'Makhwapheni Uyabulala' campaign, which means 'Secret lovers kill'. ...
... to a report in the Thursday edition of a local newspaper, ... condoms for the first time in Vietnam.// ,As a ... of condoms under a law on HIV/AIDS slated to come into ... not allowed in inns as prostitution has been reported in many ...
... cells which act like parasites, infecting dogs around the ... oldest known cancer cells. ,Canine transmissible venereal ... domestic dogs through sexual contact and also through licking, ... that unlike cervical cancer in humans that is caused ...
... project they've begun to draw out a new kind of ... susceptible or resistant to certain diseases. ,It has ... being undertaken by the researchers of the Emory University was ... published in the scientific journal, Genome Research. Lisa Brooks the ...
... Toronto will begin on Sunday, bringing together over 20,000 community ... a more active role in the battle with this scourge. ... around the world especially in sub-Saharan Africa which is still ... nearly 9 out of 10 children diagnosed with HIV/AIDS live ...
Cached Medicine News:Health News:Computerized Patient Used to Teach Science to Medical Students 2Health News:AIDS Campaign Enrages HIV Infected Swazis 2Health News:Venereal Cancer in Dogs Transmitted by Contagious Cancer Cells 2Health News:Researchers from Emory University Undertake A New Genetic Mapping 2Health News:Church to Have an Active Role in the Prevention of AIDS 2
(Date:7/30/2015)... ROCHELLE PARK, N.J. , July 30, 2015 /PRNewswire/ ... is voluntarily recalling one lot of Hydrochlorothiazide tablets 25 ... has been initiated as a precautionary measure due to ... bottle of the product. The risk ... a Hydrochlorothiazide tablet is the increased probability of experiencing ...
(Date:7/30/2015)... OAKS, Calif. , July 30, 2015  Amgen (NASDAQ: ... Hassan , partner and managing director of Warburg Pincus LLC, ... are pleased to welcome Fred Hassan and the ... the Amgen Board," said Robert A. Bradway , chairman ... and commitment to innovation will serve Amgen well." ...
(Date:7/30/2015)... 30, 2015  Growth of the U.S. nonprescription market ... former prescription users to the OTC market. Due to ... robust Rx-to-OTC switch activity over the next five years ... many new brands entering the market into existing categories. ... five years (even those with low to moderate likelihood), ...
Breaking Medicine Technology:Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3
... UCB announced today results from a post hoc ... Journal of Rheumatology. The results suggest moderate ... (certolizumab pegol), the only approved PEGylated anti-TNF, together with ... long-term outcomes one year after treatment began. ...
... 2011 PRO-DEX, INC. (Nasdaq: PDEX ) today ... months ended March 31, 2011. Sales for ... higher than sales of $6.2 million for the corresponding quarter ... sales were $19.6 million, 12% higher than sales of $17.5 ...
Cached Medicine Technology:Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 2Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 3Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 4Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 5Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 6Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 7Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 8Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 9Cimzia® (certolizumab pegol) Data Showed Rapid Improvement in Signs and Symptoms Predicted Better Long-Term Outcomes in Rheumatoid Arthritis Patients 10Pro-Dex, Inc. Announces Fiscal Third Quarter and Nine Month Results 2Pro-Dex, Inc. Announces Fiscal Third Quarter and Nine Month Results 3Pro-Dex, Inc. Announces Fiscal Third Quarter and Nine Month Results 4Pro-Dex, Inc. Announces Fiscal Third Quarter and Nine Month Results 5Pro-Dex, Inc. Announces Fiscal Third Quarter and Nine Month Results 6Pro-Dex, Inc. Announces Fiscal Third Quarter and Nine Month Results 7
... easy and economical generation of a hypoxic ... Chamber utilizes a surface-type seal where all ... by a stainless steel ring clamp for ... and semi-spherical top and bottom provide minimum ...
... A wide range of miniTHERM incubators is ... appropriate application solution for their specific requirements. ... liters, are compact and extremely space saving. ... microwave oven. It is possible to stack ...
... A wide range of miniTHERM incubators ... the appropriate application solution for their specific ... 18 liters, are compact and extremely space ... typical microwave oven. It is possible to ...
... corrosion resistance of stainless steel with ... SANYO offers an electro-polished copper-alloy-stainless interior ... The sterile environment promotes the integrity ... the safety of laboratory staff. This ...
Medicine Products: