Navigation Links
Giving transplanted cells a nanotech checkup
Date:2/5/2013

, sensor filled with L-arginine, a nutritional supplement that responds chemically to small changes in acidity (pH) caused by the death of nearby cells. Changes in the acidity would in turn set off changes in sensor molecules embedded in the thin layer of fat that makes up the outside of the nanoparticle, giving off a signal that could be detected by MRI.

To test how these nanosensors would work in a living body, the team loaded them into hydrogel spheres along with liver cells a potential therapy for patients with liver failure and another sensor that gives off bioluminescent light only while the cells are alive. The spheres were injected just under the skin of mice. As confirmed by the light signal, the MRI accurately detected where the cells were in the body and what proportion were still alive. (Such light indicators cannot be used to track cells in humans because our bodies are too large for visible signals to get through, but these indicators allowed the team to check whether the MRI nanosensors were working properly in the mice.)

"It was exciting to see that this works so well in a living body," Chan says. The team hopes that because the components of the system hydrogel membrane, fat molecules, and L-arginine are safe for humans, adapting their discovery for clinical use will prove relatively straightforward. "This should take a lot of the guesswork out of cell transplantation by letting doctors see whether the cells survive, and if not, when they die," Chan says. "That way they may be able to figure out what's killing the cells, and how to prevent it."

Potential applications of the sensors are not limited to cells inside hydrogel capsules, Bulte notes. "These nanoparticles would work outside capsules, and they could be paired with many different kinds of cells. For example, they may be used to see whether tumor cells are dying in response to chemotherapy," he says.


'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Immigrant women giving birth in Spain suffer great stress, a study warns
2. Giving makes young children happy, UBC study suggests
3. The Alzheimer’s Caregiver™ Offers a New Educational Concept of Care That Bridges the Gap between Research and Caregiving
4. 3M™ Gripping Material Technology – Giving Golfers a Competitive Edge
5. 1 in 3 post-partum women suffers PTSD symptoms after giving birth
6. Giving lithium to those who need it
7. Kessler Foundation scientists report negative impact of long-term caregiving on cognition
8. Kick Off the Holiday Season With a Healthier Thanksgiving
9. Spread the Purple Launches New Website Just in Time for Winter Holiday Giving Season
10. Omega3 Innovations Helps Local Food Bank Provide Thanksgiving Dinners for those in Need
11. Zion Health Announces Holiday Earth Gifts for the Season of Giving Now Available at Whole Foods Market in Lafayette, CA
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Giving transplanted cells a nanotech checkup
(Date:7/13/2014)... Genetics identifies a novel genetic and molecular ... (EoE), opening up potential new therapeutic strategies for ... EoE is a chronic inflammatory disorder of the ... to certain foods and an over-accumulation in the ... of the body,s immune system). EoE can cause ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Recently, MillionaireCasket.com, a ... of oak caskets . Additionally, the company’s chief executive ... All the new oak caskets are offered at discounted prices, ... I am concerned, quality caskets are in huge demand in ... oak caskets . We have a lot of high ...
(Date:7/13/2014)... Micro irrigation systems are mainly utilized for agriculture ... as to maintain soil quality. The application of micro ... dominant revenue generator for manufacturers in future. The trend ... has led to the adoption of micro irrigation techniques ... massive demand for micro irrigation systems, as they reduce ...
(Date:7/13/2014)... 2014 Fuel additives are chemicals, which ... jet fuel, kerosene, and so on, in order to ... reducing the corrosion effects caused by fuels and improving ... any fuel, provide economies of scale in the long ... overall cost of the fuel products. , The various ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 A Massachusetts ... to the cancer risks associated with power morcellators ( ... their story to federal regulators, as they presented poignant ... Food & Drug Administration (FDA) advisory panel meeting convened ... According to the Rochester Democrat and Chronicle, Dr. Hooman ...
Breaking Medicine News(10 mins):Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 3Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 2Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 3Health News:Couple Who Brought Attention to Morcellator Cancer Risks Testify on Second Day of FDA Advisory Panel Meeting, Bernstein Liebhard LLP Reports 4
... , , , , LOS ... Christmas " presentation is being telecast over multiple broadcasts, cable ... million homes this year. Participating stars and other notables include ... Nicole Kidman, Bob Costas, and Natalie Cole. , (Photo: ...
... , CLASS Act Long-Term Care Provision Key to Reform ... the National Council on Aging: , WASHINGTON, Dec. 23 The ... and Affordable Care Act (H.R. 3590), which, when passed, will bring ... care that is both accessible and affordable for Americans of all ...
... Inhibition of transcription factor E2F1 reduced epidermal growth factor ... not proliferation of metastatic melanoma cells, according to a ... Journal of the National Cancer Institute . To ... M.D., Ph.D., of the department of vectorology and experimental ...
... say, , WEDNESDAY, Dec. 23 (HealthDay News) -- A ... can have a dark side, with asymptomatic children passing ... get colonized by strep and pneumococcus, and they are ... it, but the elderly are more susceptible to it," ...
... , , LOS ANGELES, Dec. 23 ... risky behavior on the lighter side and a total depletion of honesty ... a lack of production at work and even murder, those who fall ... the declining moral fabric of our society. , Narconon is considered by ...
... detailed search of breast cancer genomes to uncover genomic ... in which the human genome is broken and put ... Rearrangements involve reshuffling and reorganisation of the genome ... sequences. The study shows that breast cancer samples can ...
Cached Medicine News:Health News:Top Stars Rally for Fighting Blindness, Sending Their Message out to 160 Million Homes on Multiple Cable Networks, December 25th, Preceded by President George Herbert Walker Bush Describing the Frank Capra Classic, 'It's A Wonderful Life' for the Bl 2Health News:NCOA Supports Senate Health Reform Bill 2Health News:NCOA Supports Senate Health Reform Bill 3Health News:Kids Can Pass Pneumonia Bug to Older Relatives During Holidays 2Health News:Narconon Helps Restore Honesty and Trust to Former Addicts 2Health News:Narconon Helps Restore Honesty and Trust to Former Addicts 3Health News:Broken genomes behind breast cancers 2Health News:Broken genomes behind breast cancers 3
(Date:7/10/2014)... BURLINGTON, Mass. , July 10, 2014 /PRNewswire/ ... three-quarters of surveyed infectious disease (ID) specialists are ... Medicines Company,s Orbactiv (oritavancin) for use as OPAT, ... to prescribe these agents to their hospital inpatients. ... percent) of OPAT patients are initiated on OPAT ...
(Date:1/15/2014)... , Jan. 15, 2014 Sono-Tek Corporation (OTC BB: ... ended November 30, 2013, compared to sales of $2,202,000 for ... Once again, this quarter has also shown growth over the ... first quarter of this fiscal year. Markets that experienced sales ...
(Date:1/15/2014)... 15, 2014 As health officials across the Midwest warn ... pharmacies in Michigan will offer free ... enabling Meijer pharmacists to administer tests and, in some cases, ... physician participating in the study. The ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... YORK, Nov. 14, 2011 Reportlinker.com announces that ... its catalogue: Test-Volume-Sales-Forecasts-and-Supplier-Shares-by-Country.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic title=,The ... Japan Test ... 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, ...
... Medical Incorporated (OTCBB: ONCS), which is developing its advanced-stage ... today that Punit Dhillon, President and CEO, will be ... in Irvine, California. (Logo: http://photos.prnewswire.com/prnh/20110314/MM64943LOGO ) ... Forum Hyatt Regency Irvine 17900 Jamboree Road Irvine, ...
Cached Medicine Technology:The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 2The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 3The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 4The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 5OncoSec to Present at Medical Device Investor Forum 2
... instrument and custom filter wheels with ... The standard filter set includes: FAM/SYBR ... Red (585nm-610nm), Cy5 (635nm-665nm) and Cy3 ... analysis software, Beacon Designer oligo software, ...
... rapid, real-time thermal cycler used for identifying ... much of the testing process, and making ... the fastest, easiest to use, and most ... SmartCycler delivers highly accurate and consistent test ...
... SmartCycler System is a rapid, real-time thermal ... biological samples. By automating much of the ... individually programmable, it is the fastest, easiest ... on the market. The SmartCycler delivers highly ...
... The Applied Biosystems 7300 Real-Time ... real-time PCR capabilities with exceptional budget ... you to perform gene expression analysis, ... assays with internal positive controls ...
Medicine Products: