Navigation Links
Girls with family history of breast disease should avoid alcohol
Date:11/13/2011

Adding to research linking alcohol to breast cancer risk, a new study from Washington University School of Medicine in St. Louis shows that adolescent girls with a family history of breast disease either cancer or the benign lesions that can become cancer have a higher risk of developing benign breast disease as young women than other girls. And unlike girls without a family history, this already-elevated risk rises with increasing alcohol consumption.

"The most common question we hear from women with a family history of breast disease is how can we prevent breast cancer in our daughters," says epidemiologist Graham A. Colditz, MD, PhD, the Niess-Gain Professor of Surgery and senior author on the study published online Nov. 14 in the journal Cancer. "This points to a strategy to lower risk or avoid increasing risk by limiting alcohol intake."

This study is one of the first to look at alcohol consumption in adolescents and the risk of breast disease. Most studies linking alcohol to the risk of developing breast cancer focus on women in their 40s, 50s and 60s and on their risk of invasive breast cancer, not the risk of early, benign lesions that may lead to invasive breast cancer.

One such study published Nov. 2 in the Journal of the American Medical Association, in which Colditz was a co-author, found a moderate increase in breast cancer risk with as few as three to six drinks per week for any adult women, regardless of family history.

"In the current study, we have tried to disentangle the effects of alcohol in women with a family history that includes both breast cancer and benign breast disease, compared to women with no family history," Colditz says. "And we're seeing the strongest effect of alcohol in women with breast disease in the family."

The new study of younger women began in 1996 with more than 9,000 girls from all 50 states who are daughters of participants in the Nurses' Health Study II. The girls were ages nine to 15 when they completed baseline questionnaires. Follow-up questionnaires over the next five years and surveys in 2003, 2005 and 2007 tracked family history, alcoholic beverage intake, height, weight, waist circumference and age of first menstrual period, among other factors that influence breast cancer risk.

The 2005 and 2007 surveys, conducted when the participants were ages 18 to 27, asked whether they had ever been diagnosed with benign breast disease, a large class of conditions that can cause breast lumps or pain and are a known risk factor for breast cancer. Sixty-seven of the young women reported a diagnosis of benign breast disease that was confirmed by biopsy, and 6,741 reported no such diagnosis.

The researchers first looked at the effects of family history, independent of alcohol. They found that when a young woman's mother or aunt had breast cancer, she was more than twice as likely to be diagnosed with benign breast disease than a young woman with no family history. Similarly, daughters of mothers with benign breast disease were almost twice as likely to develop benign breast disease themselves.

And alcohol heightened a young girl's risk further if she had a family history. Girls whose mothers, aunts or grandmothers had breast cancer were more likely to develop benign breast disease, and their risk increased with the amount of alcohol they consumed. The same was true of the daughters of women with benign breast disease.

In an interesting finding, young women with no family history of breast disease saw no elevated risk of benign breast lesions with alcohol consumption. Instead, their risk appeared to be related to increased body mass index in childhood, waist circumference in adolescence and height in adulthood. Such findings suggest that risk factors differ between those women with a family history of breast cancer and those without.

"Increasing height is related to breast cancer risk," Colditz says. "And some data point to faster growth spurts leading to a higher risk of subsequent cancer. Obviously, that's not something we can control. But if we can understand what is going on in terms of hormones and processes in the body and the role of physical activity and diet, we may be able to modify some of that accumulation of breast cancer risk through the early years."


'/>"/>

Contact: Judy Martin
martinju@wustl.edu
314-750-4213
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Stress hormone, depression trigger obesity in girls
2. Bromley Brook Boarding School for Girls Creates Focus Cards to Help Students Regulate Emotions, Solve Problems
3. March 10 is National Women and Girls with HIV/AIDS Awareness Day
4. Teen Girls Say Pink Camel in Cigarette Ads Caught Their Eye
5. Why do sexually experienced girls resume sexual activity after abstinence?
6. Taking Care of Your 'Girls': A Fun and Open Forum for Young Women Hosted by Abington Memorial Hospital
7. Brain Glitch May Raise Some Girls Odds of Depression
8. Chemicals in Beauty Products Tied to Early Puberty in Girls
9. Most states offer HPV vaccinations to girls in juvenile justice system
10. Teen girls talk more to parents about their dating habits than do boys
11. Long Beach Fit Body Boot Camp Commits 100% to Help the ‘Boys and Girls Club of Long Beach'
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Shamangelic Healing, Sedona ... Onnit brand Alpha BRAIN and New Mood Daily-Stress Formula for brain optimization and ... products to the store is just one more way Shamangelic Healing supports people’s ...
(Date:4/29/2016)... ... 29, 2016 , ... On Tuesday, April 26, 2016 members of the HomeTown ... of Gov. Nathan Deal on SB 258, the “Rural Health Care Relief” Bill. , ... 70% tax credit to individuals and corporations which donate directly to a “rural hospital” ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... author of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to ... and podcasted thereafter . Dr. Bernie Siegel, author of a plethora of ...
(Date:4/29/2016)... ... April 29, 2016 , ... Conditions were ideal for ... Island Park on Sunday, with sunny skies, a light breeze and temperatures in the ... , The 5k Run and Walk and 1-mile walk were held to ...
(Date:4/29/2016)... ... 29, 2016 , ... A new study by a Johns ... hernia have better survival rates if surgery is performed early. Approximately one in ... diaphragm fails to form completely, letting abdominal organs into the chest cavity and ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016  Bayer Animal Health today announced that ... University of Florida College of Veterinary Medicine, is ... Communication Award (BECA). Brittany was selected from entries ... total of $70,000 in scholarship funds through the ... has provided a total of $232,500 in scholarship ...
(Date:4/27/2016)... , April 27, 2016 ... USD 2.14 billion by 2022, according to a ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... affecting the efficiency and accuracy delivered by the ... demand for novel urinalysis instruments and consumables. For ...
(Date:4/26/2016)... 2016 Hill-Rom Holdings, Inc. (NYSE: HRC ... the Deutsche Bank 41 st Annual Health Care Conference ... You are invited to listen to the live discussion ... it directly at http://edge.media-server.com/m/p/mr4uxgas . A recorded replay of ... the live event and accessible at the links above until ...
Breaking Medicine Technology: