Navigation Links
Girls with family history of breast disease should avoid alcohol
Date:11/13/2011

Adding to research linking alcohol to breast cancer risk, a new study from Washington University School of Medicine in St. Louis shows that adolescent girls with a family history of breast disease either cancer or the benign lesions that can become cancer have a higher risk of developing benign breast disease as young women than other girls. And unlike girls without a family history, this already-elevated risk rises with increasing alcohol consumption.

"The most common question we hear from women with a family history of breast disease is how can we prevent breast cancer in our daughters," says epidemiologist Graham A. Colditz, MD, PhD, the Niess-Gain Professor of Surgery and senior author on the study published online Nov. 14 in the journal Cancer. "This points to a strategy to lower risk or avoid increasing risk by limiting alcohol intake."

This study is one of the first to look at alcohol consumption in adolescents and the risk of breast disease. Most studies linking alcohol to the risk of developing breast cancer focus on women in their 40s, 50s and 60s and on their risk of invasive breast cancer, not the risk of early, benign lesions that may lead to invasive breast cancer.

One such study published Nov. 2 in the Journal of the American Medical Association, in which Colditz was a co-author, found a moderate increase in breast cancer risk with as few as three to six drinks per week for any adult women, regardless of family history.

"In the current study, we have tried to disentangle the effects of alcohol in women with a family history that includes both breast cancer and benign breast disease, compared to women with no family history," Colditz says. "And we're seeing the strongest effect of alcohol in women with breast disease in the family."

The new study of younger women began in 1996 with more than 9,000 girls from all 50 states who are daughters of participants in the Nurses' Health Study II. The girls were ages nine to 15 when they completed baseline questionnaires. Follow-up questionnaires over the next five years and surveys in 2003, 2005 and 2007 tracked family history, alcoholic beverage intake, height, weight, waist circumference and age of first menstrual period, among other factors that influence breast cancer risk.

The 2005 and 2007 surveys, conducted when the participants were ages 18 to 27, asked whether they had ever been diagnosed with benign breast disease, a large class of conditions that can cause breast lumps or pain and are a known risk factor for breast cancer. Sixty-seven of the young women reported a diagnosis of benign breast disease that was confirmed by biopsy, and 6,741 reported no such diagnosis.

The researchers first looked at the effects of family history, independent of alcohol. They found that when a young woman's mother or aunt had breast cancer, she was more than twice as likely to be diagnosed with benign breast disease than a young woman with no family history. Similarly, daughters of mothers with benign breast disease were almost twice as likely to develop benign breast disease themselves.

And alcohol heightened a young girl's risk further if she had a family history. Girls whose mothers, aunts or grandmothers had breast cancer were more likely to develop benign breast disease, and their risk increased with the amount of alcohol they consumed. The same was true of the daughters of women with benign breast disease.

In an interesting finding, young women with no family history of breast disease saw no elevated risk of benign breast lesions with alcohol consumption. Instead, their risk appeared to be related to increased body mass index in childhood, waist circumference in adolescence and height in adulthood. Such findings suggest that risk factors differ between those women with a family history of breast cancer and those without.

"Increasing height is related to breast cancer risk," Colditz says. "And some data point to faster growth spurts leading to a higher risk of subsequent cancer. Obviously, that's not something we can control. But if we can understand what is going on in terms of hormones and processes in the body and the role of physical activity and diet, we may be able to modify some of that accumulation of breast cancer risk through the early years."


'/>"/>

Contact: Judy Martin
martinju@wustl.edu
314-750-4213
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Stress hormone, depression trigger obesity in girls
2. Bromley Brook Boarding School for Girls Creates Focus Cards to Help Students Regulate Emotions, Solve Problems
3. March 10 is National Women and Girls with HIV/AIDS Awareness Day
4. Teen Girls Say Pink Camel in Cigarette Ads Caught Their Eye
5. Why do sexually experienced girls resume sexual activity after abstinence?
6. Taking Care of Your 'Girls': A Fun and Open Forum for Young Women Hosted by Abington Memorial Hospital
7. Brain Glitch May Raise Some Girls Odds of Depression
8. Chemicals in Beauty Products Tied to Early Puberty in Girls
9. Most states offer HPV vaccinations to girls in juvenile justice system
10. Teen girls talk more to parents about their dating habits than do boys
11. Long Beach Fit Body Boot Camp Commits 100% to Help the ‘Boys and Girls Club of Long Beach'
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
Breaking Medicine Technology: