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Girls and children exposed to tobacco smoke benefit more from montelukast (singulair)
Date:5/13/2008

o days later. Once they began taking montelukast, however, children did not need to take albuterol as often when their leukotriene levels rose. Two groups of children responded particularly well to montelukast: girls and children with high levels of cotinine in their urine, which indicated exposure to secondhand tobacco smoke. Both had statistically significant reduced sensitivity to leukotrienes once they began taking montelukast.

When looking at a general population of patients, montelukast does not appear to be very effective, said Dr. Rabinovitch. However, in certain patients, the choice of motelukast may be warranted, particularly in school-age girls and children exposed to tobacco smoke.

Dr. Rabinovitch and his colleagues also found that measuring exhaled nitric oxide, a measure of inflammation in patients breath, and leukotrienes in their urine, could also help them predict which patients would respond well to montelukast-- those with a high leukotriene/nitric oxide ratio.

Increasingly we have come to understand that asthma is not just one disease; it is more likely several diseases that present with similar symptoms. Thus different medications are likely to work for different patients, said Dr. Rabinovitch. It is important that we be more selective and tailor our medication regimen so that each child receives the most safe and effective treatment for their type of asthma.


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Contact: William Allstetter
allstetterw@njc.org
303-398-1002
National Jewish Medical and Research Center
Source:Eurekalert

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