Navigation Links
Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
Date:3/1/2010

Spanish researchers determined that rats treated with recombinant ghrelin displayed a reduction in liver fibrosis. Ghrelin, a stomach hormone, reduced the amount of fibrogenic cells by 25% in the treated rodents. Research further showed ghrelin prevented acute liver damage and reduced oxidative stress and inflammation in the animal models. Details of this study are published in the March issue of Hepatology, a journal of the American Association for the Study of Liver Diseases.

Liver diseases, such as hepatitis viruses, cirrhosis, and hepatocellular carcinoma (HCC, liver cancer), affect more than 5 million Americans with over 85,000 new cases of hepatitis reported annually, according to estimates from the Centers for Disease Control and Prevention (CDC). The World Health Organization reports over 2 billion people worldwide have some type of viral hepatitis. Those living with chronic liver disease are subject to further damage caused by fibrosis, a scaring of the liver that can lead to liver failure and the ultimate need of transplantation.

"Currently, there are no effective anti-fibrotic therapies for patients with liver disease," said Ramn Bataller, M.D., from the Hospital Clnic in Barcelona, Spain and lead author of the study. "Our aim was to determine if recombinant ghrelin could regulate the formation of fibrous tissue associated with chronic liver damage." Ghrelin is a growth hormone that plays a major role in the regulation of appetite and is primarily produced in the stomach. Prior studies have shown that ghrelin also has protective effects in other areas of the body including the pancreas, heart and gastrointestinal tract.

To assess chronic liver disease, the research team induced liver injury and fibrosis in male rats by prolonged bile duct ligation. The animals were separated into groups of 12 animals: group 1 received a saline solution, group 2 the rat recombinant ghrelin, and group 3 the ghrelin receptor agonist. Results showed that liver collagen increased 7-fold compared to control rats. Analysis revealed those animals treated with ghrelin displayed only mild collagen deposits with a decrease in fibrosis of roughly 40%.

Acute liver disease was studied in male rates by forming 3 experimental groups of 8 animals. The control group received saline and olive oil, group 2 was administered saline and carbon tetrachloride (CCl4 - to induce liver failure), and group 3 was given CCl4 along with ghrelin. In the group treated with ghrelin, researchers documented a marked reduction in liver cell damage and a decrease infiltration of inflammatory cells. Further examination found that ghrelin weakened the effects of on CCl4 on the pathways involved in hepatocyte survival and proliferation.

"In our study, we demonstrate that recombinant ghrelin regulates the fibrogenic response of the liver to acute and chronic disease. Ghrelin naturally produced in the body also inhibits the development of fibrosis in animal models and humans," said Dr. Bataller.

Researchers also analyzed ghrelin serum levels in blood samples from human patients who were asked to fast overnight. The samples collected included 67 patients with chronic hepatitis C, 24 with alcoholic hepatitis, and 24 healthy controls. In both patient groups with liver disease the ghrelin serum levels were significantly lower compared with the healthy control. Lower ghrelin serum levels were found in patients with advanced fibrosis than in those with mild fibrosis.

"Our results indicate that ghrelin may be useful in treating patients with liver disease and fibrosis by preventing scar tissue formation," suggested Dr. Bataller. In studies that tested ghrelin in patients with anorexia, gastroparesis (slow digestion caused by nerve or muscle damage), cachexia (physical wasting), and chronic heart failure the hormone was well tolerated, causing only a mild decrease in blood pressure. "Further studies should evaluate the safety and efficacy of ghrelin in patients with chronic liver disease," the authors concluded.


'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Action of ghrelin hormone increases appetite and favors accumulation of abdominal fat
2. Advanced Age No Bar to Liver Transplant
3. Researchers Find Better Way to Deliver Blood Thinner
4. Federal research plan to determine nanotech risks fails to deliver
5. Liver cancer marker could yield blood test for early detection
6. Blood Marker Might Help Spot Early Liver Cancer
7. Natural Protein Could Help Spot, Treat Liver Cancer
8. Diet Change Can Curb Fatty Liver Disease
9. US FDA Fast Tracks PI-88 for the Treatment of Post Resection Liver Cancer
10. The American Liver Foundation Appoints Rick Smith, a Twenty-Year Veteran of The MS Society, as Chief Executive Officer
11. Re-plumbing liver helps beat cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
Breaking Medicine Technology: