Navigation Links
Getting Closer to Cause of Tourette Syndrome
Date:5/5/2010

Finding hints at new treatments for the disorder that causes verbal and motor tics,,

WEDNESDAY, May 5 (HealthDay News) -- A family in which the father and all eight of his children have Tourette syndrome held clues to treating the neurological disorder that can cause debilitating, involuntary motor and verbal tics.

By studying the family's genome, researchers identified a mutation on the HDC gene that encodes the enzyme L-histidine decarboxylase, which is involved in regulating levels of the neurotransmitter histamine in the central nervous system.

While the variant itself is likely very rare -- meaning most people with Tourette syndrome don't have the precise mutation -- what's known about the gene's function in the body hints at new treatments, researchers explained.

Previous research in mice has shown that manipulating brain levels of histamine by decreasing activity of HDC makes mice more likely to have repetitive behaviors, such as biting, rearing and chewing. "Those are behaviors that on face value look like human tics," said senior study author Dr. Matthew State, an associate professor of child psychiatry, psychiatry and genetics at Yale University School of Medicine.

Drugs that increase the release of histamine in the brain, but don't affect histamine levels in other parts of the body, are in the latter stages of development. Previous research has also shown that when given to mice, the drugs decrease the repetitive behaviors.

It's possible those drugs could also help people with Tourette syndrome, State said.

"In this case, genetics may point to the function of the gene, which points to what kind of mechanisms might be involved in the disorder," State said. "The idea you could go from a rare genetic finding to a new approach to treatment is something that doesn't happen very often."

The study is published in the May 5 online edition of the New England Journal of Medicine.

Tourette syndrome tends to run in families. The disorder usually emerges in childhood and, for many, improves in adulthood. Although the causes of the syndrome are unknown, previous research suggests abnormalities in certain brain regions and in the neurotransmitters dopamine, serotonin and norepinephrine may play a role, according to the Tourette Syndrome Association.

Children who see doctors for Tourette syndrome often have other disorders as well, including depression, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder or learning disabilities, State said.

Many cases of Tourette syndrome are mild and improve over time. But severe cases can be debilitating -- socially and physically -- and current treatment options are limited, said Dr. Francis J. McMahon, chief of Genetic Basis of Mood and Anxiety Disorders at the U.S. National Institute of Mental Health.

In addition to behavioral intervention, first-line medications include antidepressants and anti-anxiety medication. More severe symptoms of the syndrome can be treated with antipsychotic medications such as risperidone (Risperdal) or neuroleptic medications, such as haloperidol (Haldol), but long-term side effects can be serious.

McMahon called the new study "exciting."

"Here is a condition we have known for many decades to be strongly familial. There's been a huge effort put into trying to find the genes that are involved, yet we have not really come up with genetic findings until now that really explain why it runs in families," said McMahon, also scientific advisor for the Tourette Syndrome Association. "Even more importantly, the findings point us toward new treatments."

McMahon added: "There are a lot of medications in the pipeline that target the histamine pathway. This study suggests that it might be worth looking very carefully at those new drugs as a potential treatment for Tourette."

The precise mutation, McMahon said, doesn't ever need to be found again.

"The mutation may be unique to this family, but what we would suspect is that functional differences in the HDC gene or in the histamine biochemical pathway would play a role in other families," he said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more on Tourette syndrome.



SOURCES: Matthew State, M.D., Ph.D., associate professor, child psychiatry, psychiatry and genetics, Yale University School of Medicine, New Haven, Conn.; Francis J. McMahon, M.D., chief, Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, Md.; May 5, 2010, New England Journal of Medicine, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Getting What She Wants with a Click...Instant Gratification with Launch of San Francisco Women's Digital Magazine
2. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
3. Getting to the heart of cardiovascular disease among Latinos in East Los Angeles
4. Many Dont Take Blood Thinner After Getting Stents
5. Getting the bead on conception
6. Fear of getting fat seen in healthy womens brain scans
7. Getting Through the First 60 Days as a New Parent Just Got Easier
8. Getting heavier, younger: U-M study shows generational shift in obesity
9. New Breast Cancer Book Offers Humor Filled Look at Being Thirty-Something, Single And Getting Through Diagnosis
10. Some Older ER Patients Are Getting the Wrong Medicines, U-M Study Finds
11. Some older ER patients are getting the wrong medicines, U-M study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of Eating ... excellence for the field of eating disorders, announces the opening of early registration ... Orlando, Florida at the Omni Resort at ChampionsGate. , The annual ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with ... for the primary prevention of cardiovascular diseases during the 15th Annual Women’s ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is ... vendors and unique items from across the nation, this holiday-themed event will raise funds ... by the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Global Healthcare ... scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare ... activity. The fun run is geared towards children of all ages; it is ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: