Navigation Links
Gestational diabetes and low socioeconomic status linked with increased risk of ADHD in offspring
Date:1/2/2012

CHICAGO Children exposed to maternal gestational diabetes mellitus and low socioeconomic status, particularly in combination, appear to be at an increased risk of developing childhood ADHD, according to a report published Online First by Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

"Gestational diabetes mellitus (GDM) typically develops in the second and third trimesters and is defined as glucose intolerance with onset or first recognition during pregnancy," the authors write as background information in the article. "The prevalence of GDM has been rising for over 20 years, particularly among ethnic minorities and individuals with low socioeconomic status (SES), as have lifestyle changes that heighten risk including greater consumption of saturated fats, sugar, and processed foods, and sedentary working environments."

To examine the association of gestational diabetes mellitus (GDM) and low socioeconomic status with neurodevelopment and attention-deficit/hyperactivity disorder (ADHD) outcomes, Yoko Nomura, M.D., Ph.D., of Queens College, City University of New York, Flushing, and colleagues, compared offspring of mothers with and without GDM in an economically diverse sample. The authors distributed the ADHD Rating Scale-IV to parents of 3- and 4-year-old children in preschools surrounding Queens College, and recruited 212 participants at a 2:1 ratio of "at risk" to "typically developing" children. At-risk children had at least six inattention or six hyperactive and impulsive symptoms as rated by parents, teachers, or both. "Typically developing" children had fewer than three symptoms in each domain.

The mean (average) inattention score at baseline for offspring exposed to mother's GDM was significantly higher than for offspring unexposed, but there was no difference in hyperactivity/impulsivity scores between the two groups. Children in low SES families, compared to high SES families, had greater inattention and hyperactivity/impulsivity scores. The results showed no difference in the risk for ADHD at baseline, but a two-fold increased risk at age 6 years among children exposed to GDM compared with children who were not exposed. There was also a two-fold increased risk for ADHD at baseline and at age 6 years among children in low SES families.

Children exposed to both GDM and low SES showed compromised neurobehavioral functioning, including lower IQ, poorer language abilities and diminished behavioral and emotional functioning. When examining the relationship of both GDM and SES exposure on outcomes, the authors found a 14-fold increased risk of developing ADHD among children exposed to both GDM and low SES. Conversely, children exposed to maternal GDM alone or low SES alone had no significant increased risk for ADHD.

"This study demonstrates that children of mothers with GDM raised in lower SES households are at far greater risk for developing ADHD and showing signs of suboptimal neurocognitive and behavioral development," the authors conclude. "Since ADHD is a disorder with high heritability, efforts to prevent exposure to environmental risks through patient education may help to reduce the nongenetic modifiable risk for ADHD and other developmental problems."

(Arch Pediatr Adolesc Med. Published online January 2, 2012. doi:10.1001/archpediatrics.2011.784. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Environment, Developmental Origins and ADHD

In an accompanying editorial, Joel Nigg, Ph.D., of Oregon Health and Science University, Portland, writes, "In the current issue of the Archives we see additional evidence, in a retrospective design, that early developmental events are related to subsequent attention-deficit/hyperactivity disorder (ADHD) in children."

"Most of the relevant environmental risks are presumed to occur very early in development," continues Dr. Nigg. "If causal, and if able to be understood pathophysiologically, such environmental effects on ADHD are of 'game-changing' importance because they open the door to eventually preventing that portion of cases of ADHD caused by early insult to the nervous system."

"If a specific environmental causal influence can be demonstrated, even if effective in a subset of children, and its biological mechanisms elucidated, then a powerful model will be created for how ADHD can develop," Dr. Nigg concludes. "That discovery will be a crucial stepping-stone toward parsing multiple causal routes to what may be a final common pathway of the ADHD phenotype."

(Arch Pediatr Adolesc Med. Published online January 2, 2012. doi:10.1001/archpediatrics.2011.905. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: Please see the article for additional information, including author affiliations, financial disclosures, funding and support, etc.


'/>"/>

Contact: Queens College News Services
maria.matteo@qc.cuny.edu
718-997-5593
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Age and BMI can predict likelihood of developing gestational diabetes new research suggests
2. African-American women with gestational diabetes face high long-term diabetes risk
3. Gestational Diabetes Predictable Before Pregnancy, Experts Say
4. Gynecologic cancer expert helps pinpoint best treatment for fast-growing gestational tumors
5. Gestational Period Depends on Structure of Placenta: Research
6. Can Wii help control gestational diabetes?
7. Metabolic status before pregnancy predicts subsequent gestational diabetes
8. Women with gestational diabetes have increased risk of recurrence in subsequent pregnancies
9. Gestational Diabetes Linked to Serotonin and Dietary Protein
10. Twice as Many Women May Soon Be Diagnosed With Gestational Diabetes
11. Pregnancy Weight Gain, Especially in 1st Trimester, May Increase a Womans Risk of Gestational Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... is actively feeding the Frederick area economy by obtaining investment capital for emerging ... the past 2½ years that have already resulted in more than a million ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a provider of ... other difficult to transfect cells, announces its launch of the PluriQ™ G9™ Gene ... System is a complete system for culturing and transfecting human pluripotent stem ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
(Date:6/23/2016)... MOUNTAIN VIEW, Calif. , June 23, 2016 ... 9:00 a.m. CST on Thursday, July 7, 2016 , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  ... Sciences, Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, ... The global pharmaceutical industry is witnessing ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia ... the company,s second affiliate in Latin America . ... ... Farma Colombia ... ...
Breaking Medicine Technology: