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Gestational Diabetes Linked to Serotonin and Dietary Protein
Date:6/28/2010

ibly, the long-term risk of developing type 2 diabetes, according to the researchers. The dual roles of serotonin in regulating mood and beta cell mass also could explain the association of depression with both type 2 diabetes and gestational diabetes, as well as the effects of some classes of psychiatric medications on diabetes. The researchers noted that a more complete understanding of the function of this pathway could suggest improved methods for both preventing and treating diabetes.

The lead author on the paper was Hail Kim, who is a researcher in the UCSF Diabetes Center along with co-authors Francis C. Lynn, Eric Chak, Takeshi Miyatsuka, Yasuhiro Kosaka, Katherine Yang, Nina Kishimoto and Juehu Wang.

Other co-authors include Yukiko Toyofuku, Toyoyoshi Uchida, Yoshio Fujitani, Ryuzo Kawamori and Hirotaka Watada, all of the Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Hiroki Mizukami, from the Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Yoshio Fujitani and Soroku Yagihashi, from the Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo; and Gerard Honig and Marieke van der Hart, from the UCSF Department of Psychiatry. Kawamori is also affiliated with the Center for Beta Cell Biology and Regeneration, and the Sportology Center, of the Juntendo University Graduate School of Medicine, Tokyo.

The research was supported by grants from the Larry L. Hillblom Foundation, the Juvenile Diabetes Research Foundation, the American Diabetes Association, the National Institutes of Health and the Ministry of Education, Sports and Culture of Japan. The authors declare no conflicts of interest.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and heal
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