Navigation Links
Geranylgeraniol suppresses the viability of human prostate cancer cells and HMG CoA reductase
Date:11/13/2013

Researchers at Texas Woman's University have shown that a diterpene geranylgeraniol found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, suppressed the viability of human DU145 prostate carcinoma cells via cell cycle arrest at the G1 phase and the initiation of apoptosis. This finding, reported in the November 2013 issue of Experimental Biology and Medicine, supplies recent evidence supporting the tumor-suppressive potential of dietary isoprenoids, a class of phytochemicals encompassing ~55,000 mevalonate-derived secondary metabolites.

"This line of work dates back to the 1980s when the University of Wisconsin groups led by Drs. Charles Elson and Michael Gould discovered the anti-tumor activity of monoterpenes and soon after, sesqui- and di-terpenes." said Dr. Huanbiao Mo, senior author and professor in the Department of Nutrition and Food Sciences. These compounds, widely present in fruits, vegetables and grains, were found to be much more effective in suppressing the growth of tumor cells than that of normal cells. A study by Mo's group in a 2011 issue of Experimental Biology and Medicine (236:604-613) showed that normal fibroblasts are 10-fold more resistant than murine B16 melanoma cells to geranylgeraniol-mediated growth suppression. This tumor-targeted action of isoprenoids was manifested in animal studies showing no toxicity of isoprenoids at tumor-suppressive doses (reviewed by Mo & Elson, Exp Biol Med, 2004, 229:567-85). Previous work also suggested synergistic impact of isoprenoids on tumor growth, a finding remaining to be confirmed in prostate cancer.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor-suppressive activity of geranylgeraniol was accompanied by down-regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the p
'/>"/>

Contact: Huanbiao Mo
hmo@mail.twu.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. PhenObestin 37.5 Suppresses Appetite as APA lists Binge-Eating as a Disorder
2. UNC researchers discover gene that suppresses herpesviruses
3. Key molecule suppresses growth of cancerous liver tumors, Mayo study finds
4. Lactation protein suppresses tumors and metastasis in breast cancer
5. Experimental Drug Suppresses Appetite in Mice: Study
6. Protect Cell Viability Outside the Incubator While Trypsinizing Cells During Cell Passaging with the Scienceware® CultureTemp™ 37°C Warming Plate by Bel-Art Products
7. Study: Methodology of determining financial viability of social security
8. Tel Aviv University part of team launching global Human Brain Project
9. Western University of Health Sciences’ Gala Fundraiser Emphasizes Humanism and Caring
10. Animal, human health benefits anticipated from universitys premier biomedical instrument
11. ENT and Allergy Associates, LLP® Adds Resources to Its Human Resources Department, Welcomes Eric M. Saidel, JD as Its New HR Director
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... 24, 2014 A new sports ... pre-eminent pain-relief service and massage therapy provider, announced ... (ESM). This newest sports massage is ... difference between traditional sports massage and ESM is ... body's very own "reset button,” and ESM can ...
(Date:11/24/2014)... November 24, 2014 SWAccessControl.com has ... As a matter of fact, the company is a leading ... brand new magnetic locks are available at discounted prices, up ... new range of magnetic locks. This time, all of our ... popular at home and abroad, so I have confidence in ...
(Date:11/24/2014)... and Philadelphia, PA (PRWEB) November 24, 2014 ... of care coordination and disease management services to ... chosen to implement Essette’s Medical Management software suite. ... Essette SaaS platform in a program to reduce ... suite includes Population Health Management, Care Management, Utilization ...
(Date:11/23/2014)... The clinical trial report, "Aspergillosis Global ... the Aspergillosis clinical trial scenario. This report provides ... trials on Aspergillosis. It includes an overview of ... per the site of trial conduction across the ... disease clinical trials by their phase, trial status, ...
(Date:11/23/2014)... Tbdress.com has recently announced that its Special Friday Shoes ... special offer will provide ladies many gorgeous shoes at greatly ... largest women’s dresses retailers, and its shoes include many models ... on that day: Everything at Tbdress.com is up to 90% ... , People can use the following coupon codes as well: ...
Breaking Medicine News(10 mins):Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 3Health News:SWAccessControl.com Is Happy To Release New Range Of Magnetic Locks 2Health News:ReAdmission Solutions, LLC Selects Essette 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 3Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 4Health News:Tbdress.com Special Friday Shoes Sales Online Now 2
... Annapolis Media ... Event, ANNAPOLIS, Md., Sept. ... will have used,an inhalant by the 8th grade. In Maryland, inhalant use is ... are,the drug of choice, with use rates over twice the rate of marijuana ...
... 28 With audience members cheering and,famous Chicago chefs ... cooker for the finalists at Consorta,s Battle of the ... as the organic cucumbers he,serves the patients at Saint ... the event,s Gold Chef Award, becoming the reigning champion ...
... "Tonight the candidates,lost an opportunity to engage in ... dominate people,s day to day lives. (Logo: ... in the African American,community, with one in four adults ... able to afford to retire. "With just one ...
... has recently inspired research into its therapeutic value ... prevention. A painful, progressive autoimmune disease, rheumatoid ... of depressiondouble the risk of the healthy population, ... Increasingly, RA patients are turning to alternative ...
... raised in bilingual homes learned two similar-sounding words in a ... raised in homes where only one language is spoken. This ... appears to be due to the fact that bilingual babies ... words and objects (often a word in each language) for ...
... In a victory for the,families of small business ... legislation that will improve accessibility of the State,Children,s ... and Olympia Snowe (R-Maine) attached an amendment to ... to enroll more,children in the program. The provision ...
Cached Medicine News:Health News:National Battle of the Hospital Chefs Cooks Up a Winner 2Health News:Post-Debate Statement from AARP Board Member Joyce Payne 2Health News:Meditation therapy for rheumatoid arthritis patients 2Health News:Meditation therapy for rheumatoid arthritis patients 3Health News:Babies raised in bilingual homes learn new words differently than infants learning one language 2Health News:Babies raised in bilingual homes learn new words differently than infants learning one language 3Health News:Bipartisan Bill Expands Health Care Access for Small Businesses 2
(Date:11/24/2014)...  Surgical Theater, LLC, announced today that their technology ... opening of Europe,s first simulation ... The SuRgical Planner (SRP) and the Surgical Navigation Advanced ... their 3D navigation and augmented reality capabilities in the ... and Chair, Department of Neurosurgery at Mount Sinai Health ...
(Date:11/24/2014)... 24, 2014  Inovio Pharmaceuticals, Inc. (NASDAQ: INO ... President and CEO of Inovio Pharmaceuticals, will be joined by ... the Nasdaq Opening Bell tomorrow, Tuesday November 25, 2014, at ... listing on the Nasdaq Global Select Market.  ... "We are honored to ring the Nasdaq Opening Bell on ...
(Date:11/22/2014)... N.J. , Nov. 21, 2014  CytoSorbents ... commercializing its European Union approved CytoSorb® cytokine adsorber ... was awarded the Beacon of Light Award at ... Celebration.  Dr. Phillip Chan ... is an honor to be recognized by the ...
Breaking Medicine Technology:Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 2Surgical Theater's Technology to be Showcased at the Opening of the Besta NeuroSim Center in Milan, Italy 3Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 2Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 3CytoSorbents Wins Beacon of Light Award 2CytoSorbents Wins Beacon of Light Award 3CytoSorbents Wins Beacon of Light Award 4
... Texas Children,s Hospital and 16 other top pediatric ... Houston to analyze results from their 39-month national ... Ventricular Assist Device (VAD), a German-manufactured pediatric mechanical ... http://bit.ly/bfrA1J (Photo:   http://photos.prnewswire.com/prnh/20101021/DC86640 ...
... N.J., Oct. 21 CANTEL MEDICAL CORP. (NYSE: ... an increase in its semiannual cash dividend to $0.06 per outstanding ... January 28, 2011 to shareholders of record at the close of ... of the Board, said, "We are pleased to announce the dividend ...
Cached Medicine Technology:Texas Children's Hospital Hosts North American Investigators on Berlin Heart Trial 2Texas Children's Hospital Hosts North American Investigators on Berlin Heart Trial 3Texas Children's Hospital Hosts North American Investigators on Berlin Heart Trial 4Cantel Medical Board of Directors Authorizes Increase in Semiannual Dividend 2
... Topical Anesthetic, ,Designed for adolescent ... incorporates an additional lumen and injection ... anesthetic above and below the cuff., ... designs which allow for CO2 monitoring, ...
Laryngectomy Tubes with special J-shape for convenient placement through a tracheostomy stoma....
SHERIDAN PREFORMED Endotracheal Tubes are designed to conveniently position the anesthesia circuit out of the surgical field for oral and maxillofacial procedures....
Pre-Loaded with a Stylet., ,Available Cuffed or Uncuffed, pre-loaded with a stylet to facilitate quick intubations....
Medicine Products: