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George Mason University researchers target breast cancer in 3 trials
Date:11/1/2012

Fairfax, Va. -- A malarial drug is showing promise in stopping breast cancer before it starts, Mason researchers are discovering during a clinical trial.

"The bold long-term goal is a short-term oral treatment that prevents breast cancer by killing the precursor cells that initiate breast cancer," says Lance Liotta, co-director of Mason's Center for Applied Proteomics and Molecular Medicine (CAPMM). "And it's looking hopeful."

The PINC trial (Preventing Invasive Neoplasia with Chloroquine) targets ductal carcinoma in situ, or DCIS, the most common type of pre-invasive breast cancer. Chloroquine is a drug given to prevent or treat malaria; it's showing promise in the early phase of the PINC trial.

CAPMM has three ongoing breast cancer research projects, including the PINC trial, which span the full scope of breast cancer's impact on patients.

In the PINC trial, DCIS is the focus. DCIS shows up as white spots in the MRI of a breast. Those white spots are calcifications that may mark the milk ducts where DCIS cells are growing, says Virginia Espina, assistant research professor at CAPMM. Not all DCIS becomes cancer, but all breast cancer goes through the DCIS stage, she says.

If the patient is diagnosed with DCIS after a biopsy, then she can enter the trial, says Espina, adding that the study doesn't interfere with standard medical treatment. Mason researchers are working with Kirsten Edmiston, a surgeon at Inova Fairfax Hospital who recruits the patients and clinically directs the trial.

While patients are waiting between their diagnosis and the surgery, they take chloroquine once a week for four weeks, Espina says.

A significant reduction in the lesion's size is the sought-after outcome, Espina says. The widely prescribed malaria drug chloroquine has few side effects a rare rash is one, Espina says. There could come a day when chloroquine is taken by women worldwide to prevent breast cancer.

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Contact: Michele McDonald
mmcdon15@gmu.edu
703-993-8781
George Mason University
Source:Eurekalert

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