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Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year
Date:2/13/2008

al studies, Mozobil showed the ability to quickly and predictably

prepare cancer patients for a transplant to treat their disease.

Genzyme plans to file mid year for U.S. and European approval for the

product's use in treating patients with multiple myeloma and patients

with lymphoma. The company plans to launch the product early next year

upon approval and to rapidly expand the product's availability around

the world. The company expects peak annual sales of the product in the

transplant setting of $400 million. Genzyme is also exploring

additional indications for Mozobil, including its near-term potential

use in chemosensitization procedures.

Clolar for adult AML

-- Clolar is approved in the United States and Europe for the treatment of

acute lymphoblastic leukemia in relapsed and refractory pediatric

patients. Genzyme is developing the product for use globally as a

first-line therapy for the treatment of adult acute myeloid leukemia

and myelodysplastic syndromes, significantly larger indications that

the company estimates will drive peak annual sales of the product to

approximately $600 million. The company intends to submit a

supplemental new drug application in the United States later this year

to include an adult AML indication, following the completion of its

CLASSIC II clinical trial involving older adult AML patients. The

company also expects to provide additional clinical data to European

authorities to supplement the regulatory submission filed previously by

Bioenvision.

Mipomersen for high-risk cardiovascular disease

-- Mipomersen is being developed primarily for patients at significant

cardiovascular risk who are unable to achieve target cholesterol levels

with statins alone or who are intolerant of statins. Mipomer
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SOURCE Genzyme Corporation
Copyright©2008 PR Newswire.
All rights reserved

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