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Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year
Date:2/13/2008

s labeling to include chronic kidney disease patients with

hyperphosphatemia who have not progressed to dialysis. Therefore it

will not be necessary for the company to file an sNDA for this

indication. A CKD indication will expand the market for sevelamer and

help sustain the long-term growth of the Renal franchise.

-- Sales of Synvisc(R) (hylan G-F 20) and Synvisc-ONE are expected to

reach $270-$280 million this year, compared with $242 million in 2007.

Synvisc-One received CE Mark approval in the European Union in

December. This single-injection regimen has the potential to redefine

the market for viscosupplementation products and expand the benefits of

this therapeutic approach to a broader set of patients by simplifying

osteoarthritis pain management. Genzyme will pursue marketing

approvals for Synvisc-One in Canada, Asia and Latin America based on

the European CE mark approval. Action on a marketing application in

the United States is expected later this year.

-- Transplant revenue is expected to increase to $210-$220 million this

year, compared with $175 million in 2007, driven by increasing global

demand for Thymoglobulin(R) (Anti-thymocyte Globulin [Rabbit]).

Thymoglobulin's growth is being driven by its launch in new geographic

markets and by publications and clinical studies. The product's

growth over the past several quarters has been affected by

manufacturing challenges resulting in stability issues affecting the

appearance of the product. Genzyme has worked closely with the FDA in

addressing these challenges, and has implemented process changes at its

Thymoglobulin manufacturing plant in Lyon, France. These changes have

resulted in improved stability, and Genzyme continues to work to

optimize its processes. The com
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SOURCE Genzyme Corporation
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