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Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year
Date:2/13/2008

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TOTAL REVENUE $4,500 $4,700

**GROSS MARGIN approx. 77%

**SG&A approx. 27%

**R&D approx. 17%

Net Interest / Other approx. 60

TAX RATE - GAAP approx. 30%

*TAX RATE - NON-GAAP approx. 31%

GENZ GAAP EPS approx. $2.75

AMORTIZATION approx. $0.55

FAS123 EXPENSE approx. $0.60

CONTINGENT CONVERTIBLE DEBT approx. $0.10

**GENZ NON-GAAP EPS $4.00

***WTD AVERAGE SHARES O/S approx. 274

CAPITAL EXPENDITURES approx. $500

This financial guidance, which is provided as part of a press release dated February 13, 2008, is subject to all of the qualifications and limitations described therein. Actual results may differ from these forward- looking statements due to the numerous factors described in the press release.

*Non-GAAP tax rate excludes the impact of amortization, one-time events,

FIN 46, FAS123 expense and EITF 04-08.

**Non-GAAP excludes the impact of amortization, one-time events, FIN 46,

FAS123 expense and EITF 04-08.

***WTD Average Shares Outstanding excludes the impact of EITF 04-08.


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SOURCE Genzyme Corporation
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