Navigation Links
Genta Announces Licensing Agreement for Worldwide Development and Commercialization of a Leading Oral Taxane, Tesetaxel
Date:3/7/2008

BERKELEY HEIGHTS, N.J., March 7 /PRNewswire-FirstCall/ -- Genta Incorporated (Nasdaq: GNTA) announced today the Company has entered into an exclusive worldwide licensing agreement with Daiichi Sankyo Company, Limited (TYO: 4568) for the development and commercialization of tesetaxel (formerly known as DJ-927). As a late Phase 2 oncology product, tesetaxel has demonstrated anticancer activity in its initial clinical trials, and the drug has not been associated with the severe infusion reactions that are linked with other taxanes, such as paclitaxel (Taxol(R)) and docetaxel (Taxotere(R); sanofi aventis). Moreover, unlike other oral taxanes that are currently in clinical development, nerve damage has not been a prominent side effect of tesetaxel. Preclinical studies also show that tesetaxel does not share resistance mechanisms that are associated with other taxanes. Thus, the drug offers substantial opportunities to improve patient convenience, safety, and anticancer activity.

Under terms of the agreement, Daiichi Sankyo will receive upfront payments, payments pursuant to the achievement of certain milestones, and royalties on product sales.

"Tesetaxel has demonstrated promising antitumor activity with an acceptable safety profile that offers potential use in a variety of cancer types," commented Dr. Anthony W. Tolcher, Clinical Director of South Texas Accelerated Research Therapeutics (START) in San Antonio, TX. "As someone who tested this product and other oral taxanes over the past several years, I am distinctly pleased to see it return to active clinical development."

More than 250 patients worldwide have been treated with oral tesetaxel in Phase I and Phase 2 clinical trials. The major side-effect of tesetaxel in cl
'/>"/>

SOURCE Genta Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Genta Announces Resignation of Dr. Betsy McCaughey from Board of Directors
2. Genta to Present at Bio Investor Forum 2007 Conference
3. IVCC launches groundbreaking insecticide projects with Bayer and Syngenta
4. Innocoll Agrees the Sale of its CollaRx(R) GENTAMICIN SURGICAL IMPLANT and European Sales and Marketing Infrastructure to EUSA Pharma
5. Novavax Announces Release Date of 2007 Fourth Quarter, Full Year Financial Results and Investor Conference Call
6. Genoptix Announces Participation at Lehman Brothers 11th Annual Global Health Care Conference
7. Susan G. Komen for the Cure(R) Announces Global Promise Fund to Help Women Worldwide
8. ACS Announces $57 Million Contract With Missouri HealthNet
9. Nfocus Neuromedical Announces Acquisition of StarFire Medical
10. QED International Associates Announces Changes to the HealthShares(TM) Composite and HealthShares(TM) Cancer Indexes
11. Pharos Innovations Announces First Recipient of National Award for Achievements in Chronic Care Programs and Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... of preterm birth the birth of an infant ... significant health problem that has increased over the past ... Control and Prevention (CDC), preterm birth affects nearly 500,000 ... in the U.S. While medical care has improved survival ... positively impact the neurodevelopmental outcomes of preterm infants. , ...
(Date:9/21/2014)... of the leading online stores of real and synthetic hair ... human hair lace wigs inspired by 6 famous celebrities. It’s ... latest celebrity hairstyles are. , For people who ... to choose from: a style of yaki straight lace wig, ... ombre red lace wig. People can go to the product ...
(Date:9/21/2014)... public health authorities focus on the physical activity benefits ... of Montreal reveals that for children, playing has no ... activity that is fun, done alone or with friends, ... pleasure, but also to combat boredom, sadness, fear, or ... play, authorities put aside several aspects of play that ...
(Date:9/21/2014)... Dry roasted peanuts are more likely to trigger an ... University study involving mice. , The researchers say that ... the dry roasting process are recognised by the body,s ... allergic immune response the next time it sees any ... the number of people with peanut allergies in the ...
(Date:9/21/2014)... The Laboratory Testing Services industry is composed ... on items ranging from consumer and food products to ... operators to ensure the safety and quality of their ... government safety regulations and consumer lawsuits have led to ... revenue briefly dipped in 2009 as the US economy ...
Breaking Medicine News(10 mins):Health News:Research evaluates neurodevelomental and medical outcomes in single family room NICU 2Health News:Research evaluates neurodevelomental and medical outcomes in single family room NICU 3Health News:UniWigs New Arrivals Just In- Human Hair Lace Wigs Inspired By Famous Celebrities 2Health News:Narrow focus on physical activity could be ruining kids' playtime 2Health News:Dry roasting could help trigger peanut allergy 2Health News:Laboratory Testing Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Laboratory Testing Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... 3 Nanophase Technologies (Nasdaq: ... and advanced nanoengineered products, announced today that the Company ... 28th, as its Chief Technology Officer, so that he ... was responsible for several of the Company,s key patents ...
... National Center for Health Care Informatics (NCHCI) Presented Pilot ... a Patriot Scientific company (OTC Bulletin Board: PTSC), announced ... and the National Center for Health Care Informatics (NCHCI), ... a presentation today by Raymond F. Rogers, chief executive ...
... brand made specifically for kids by kids and their ... WAT-AAH!, the first sugar-free, functional water brand made specifically ... first official "WAT-AAH! Challenge" to defy the expectation that ... the month of March, mothers who participate in the ...
... released today by Dr. Jane L. Delgado, President and ... nation,s leading Hispanic health advocacy group."We congratulate Governor Sebelius ... Health and Human Services and Nancy-Ann DeParle on her ... Health Reform."The nation will be well served at this ...
... Inc. (Nasdaq: GTIV ), a leading provider ... plans to present at two upcoming investor conferences. Gentiva ... in Miami, Florida from 9:30 a.m. to 9:55 a.m. ... Annual Raymond James Institutional Investor Conference in Orlando, Florida ...
... meal of the day has surprising impact on young ... awareness for the importance of breakfast for students, Sodexo, ... more than 470 school districts across the country, has ... Students" in time for National School Breakfast Week, March ...
Cached Medicine News:Health News:Nanophase Announces Changes in Principal Officers and Directors 2Health News:Nanophase Announces Changes in Principal Officers and Directors 3Health News:Crossflo Health Information Exchange Project Presented at HP Health and Life Sciences Symposium 2Health News:Crossflo Health Information Exchange Project Presented at HP Health and Life Sciences Symposium 3Health News:Let Water Be Water, LLC Introduces New 'WAT-AAH! Challenge' 2Health News:National Alliance for Hispanic Health Congratulates Governor Kathleen Sebelius and Nancy-Ann DeParle 2Health News:Gentiva(R) Health Services to Present at Upcoming Investor Conferences 2Health News:Gentiva(R) Health Services to Present at Upcoming Investor Conferences 3Health News:Sodexo Shares Top Breakfast Benefits for Students 2
(Date:9/20/2014)... 2014 /CNW/ - The issue: Mylan Pharmaceuticals ULC Canada, in ... its Mylan-Nitro Spray 0.4 mg/metered dose due to the product ... component. A missing "dip tube" could pose ... patient. This defect may lead patients to believe they are ... access it. Not receiving nitroglycerin could place them at risk ...
(Date:9/19/2014)... Pa. , Sept. 19, 2014  Today ... two new variable angle plating systems featuring its ... surgeons can adapt screw trajectory to match patient ... specific fragments of bone. The systems are being ... & Ankle Society (AOFAS) and the International Federation ...
(Date:9/19/2014)... Calif. , Sept. 19, 2014 Today, iHealth ... capital from Xiaomi Ventures, Ltd. for its first institutional ... to continue expanding iHealth,s global reach, accelerate growth and ...  As part of the investment, Xiaomi Ventures will join ... areas of cloud infrastructure and ecommerce. "We ...
Breaking Medicine Technology:Advisory - Mylan Pharmaceuticals recalling nitroglycerin spray due to defective pump 2DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 2DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 3iHealth Raises $25 Million to Fuel Growth and Global Market Share 2
... , SAN DIEGO, Oct. 15 Prometheus Laboratories ... announced the nationwide commercial launch of three new ... Dx and ProOnc Mesothelioma Dx. Each of these ... microRNA technology. , "Prometheus has a long and ...
... HOLLYWOOD, Fla. and PRINCETON, N.J., Oct. 15 ... preclinical and pharmaceutical product development services and PharmaNet ... development services to innovative pharmaceutical, biotechnology, generic drug ... the completion of a business development and co-promotion ...
Cached Medicine Technology:Prometheus Launches ProOnc Dx Cancer Diagnostics 2Prometheus Launches ProOnc Dx Cancer Diagnostics 3Azopharma and PharmaNet Development Group Enter Preclinical Strategic Alliance 2
... powerful, lightweight, easy to ... durable foam silicone rubber ... by machine washable cotton ... easily adjusts to all ...
... powerful, lightweight, easy to ... durable foam silicone rubber ... by machine washable cotton ... easily adjusts to all ...
Xenon surgical headlight system is durable, comfortable, lightweight and deliver dependable bright light through a patented shielded fiber optic bundle. It is easy to wear....
Solarc surgical headlight is durable, comfortable, lightweight and delivers the bright, white light expected from a xenon system, but at a fraction of the cost....
Medicine Products: