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Genomic technologies to identify toxic chemicals should be developed
Date:10/9/2007

rone to symptoms such as nausea and impaired muscle function when exposed to a common pesticide, the report notes.

Using new toxicogenomic technologies, researchers can identify toxic processes as they unfold at an early, molecular stage, long before symptoms appear. This knowledge will support the development of tests that can more accurately predict whether a chemical will be hazardous, and at what dose. The tests' sensitivity also could lead to better prediction and prevention of damage to fetuses at critical stages of development. Finally, toxicogenomic studies can inform individuals about their particular genetic vulnerabilities.

Given the potential of toxicogenomics to reduce and prevent health risks, regulatory agencies should expand their research and enhance efforts to use these methods to aid risk assessments, the report says. It also calls on the National Institute of Environmental Health Sciences and other stakeholders in government, academia, and industry to explore the feasibility of implementing a concerted human toxicogenomics initiative.

A crucial part of this effort will be the creation of a single public database to collect toxicogenomic data and integrate it with data on health effects generated by traditional toxicology studies, the report says. Such a database will let scientists see connections between activity at a molecular level and the symptoms that result, and decipher how multiple genetic reactions at the cellular level can combine to cause adverse outcomes. New studies will also be needed to generate data on the genomic effects of chemicals for which traditional toxicity data already exist. And a national "biorepository" for physical samples -- human blood and tissue, for example -- will be useful for future toxicogenomic studies. Every effort should be made to use samples already being collected for other research, the report urges.

The generation of data from such studies, and toxico
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Contact: Sara Frueh
news@nas.edu
202-334-2138
The National Academies
Source:Eurekalert

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