Navigation Links
Genomic signature in post-menopausal women may explain why pregnancy reduces breast cancer risk
Date:4/5/2011

ORLANDO, FL (April 5, 2011) Women who have children, particularly early in life, have a lower lifetime risk of breast cancer compared with women who do not. Now, Fox Chase Cancer Center researchers have identified a gene expression pattern in breast tissue that differs between post-menopausal women who had children and post-menopausal women who did not. The results will help scientists understand why pregnancy reduces breast cancer risk and may help them develop chemopreventive strategies that can provide similar protection for women who did not have children.

Pregnancy triggers differentiation and growth of breast tissue; however breast tissue in post-menopausal women looks similar regardless of childbearing history. That similarity has left researchers wondering why pregnancy is protective throughout a woman's life. This study starts to explain that effect, says Ricardo Lpez de Cicco, PhD, a senior research associate at Fox Chase, who will present the work at the AACR 102nd Annual Meeting 2011 on Tuesday, April 5.

"When a woman has multiple pregnancies beginning at a relatively young age, we see a protective effect against breast cancer," Lopez says. "In this study, we identified a post-pregnancy genomic signature that can still be seen even after menopause. That is very important because it could begin to help us understand why women who have children early benefit from a reduced risk of breast cancer throughout their lives."

By comparing gene expression in breast tissue from 44 post-menopausal women who had children and 21 post-menopausal women who did not, the team identified 208 genes that are differentially expressed. The signature was subsequently validated in an independent cohort of 61 post-menopausal women, 38 who had children and 23 who did not.

"We are now quite sure that these 208 genes 305 transcripts represent the genomic signature of the effects of pregnancy," says Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, who led the new study.

"Finding that signature was our end goal," Russo emphasizes. "If we want to develop chemopreventive strategies, then we need a standard or test to see if they are working. This genomic signature may be that standard."

Among the differentially expressed genes, the team detected several that are involved in processing RNA transcripts. Russo hypothesizes that the increased RNA processing proteins help ensure that no abnormal proteins are made, thereby reducing the likelihood of abnormal growth and cancer.

The team also saw reduced expression of cancer-associated genes in breast tissue from women who had children. For example, the insulin-like growth factor receptor, which is associated with increased cell proliferation, was expressed at a lower level in the samples from women who had children (parous) compared to samples from women who did not (nulliparous). Similarly, genes involved in stem cell maintenance were down-regulated, which may be because the mammary stem cells have already undergone proliferation and differentiation in the women who had children. By contrast, the stem cells are still poised to grow and produce new mammary tissue in the women who did not have children. Some theories of oncogenesis suggest that cancers arise from stem cells that go awry.


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. New genomics research investigates metastatic childhood cancers
2. Promise of genomics research needs a realistic view
3. NHGRI charts course for the next phase of genomics research
4. Tufts University calls for moderate approach to teaching personalized genomic testing
5. Genomic markers may head off thousands of thyroid surgeries
6. Forces for cancer spread: Genomic instability and evolutionary selection
7. Genomic Systems announces moratorium on studying and treating terminal cancer has ended
8. La Jolla Institute to develop San Diegos first center for RNAi genomics research
9. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
10. St. Jude researcher receives grant to focus on cancer pharmacogenomics in children
11. New genomic marker for tuberculosis may help identify patients who will develop the disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... York City (PRWEB) , ... May 23, 2017 ... ... (EHR), Population Health and Clinical Integration company, announced today that its iClinic ... Medical Home (PCMH) 2017 Prevalidation. NCQA recently introduced PCMH 2017 standards which ...
(Date:5/23/2017)... ... ... New England Journal Of Medicine Confirms Viability of Rory’s Regulations and Deems ... Foundation Calls on Health & Human Services, Tom Price to Adopt Rory’s Regulations Nationally- ... reported on a new study released on May 21, 2017 in the New England ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... By all ... underway in Sonoma County. While officials call for diligence, asking homeowners to scout for ... at potential health concerns. Along with the annoying buzz of mosquitos is the buzz ...
(Date:5/23/2017)... ... May 23, 2017 , ... Orbita’s Nathan Treloar will discuss the ... in San Francisco. Titled Connected Health and IoT: Technology Innovators and Disruption , ... by Parks Associates, a market research and consulting firm specializing in emerging consumer technology ...
(Date:5/22/2017)... ... May 22, 2017 , ... The ... the scientific development, healthcare training and clinical application of medical infrared imaging, has ... to perform medical thermal imaging services. , The first new educational offering is ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... is Stroke Awareness Month and Omron Healthcare is reminding ... prevent a stroke: monitor and manage your blood pressure. ... undetected and uncontrolled hypertension is a leading risk factor ... personal heart health technology, recently evolved its mission to ... and is advancing a national public education effort to ...
(Date:5/4/2017)... 2017 Clarius Mobile Health, a digital ... scanners this week at the American Congress of ... San Diego, CA from ... the perfect tool for clinicians to easily confirm ... evaluate pregnancy-related complications like ectopic pregnancy and placenta ...
(Date:5/4/2017)... BOTHELL, Wash. , May 4, 2017   ... a leading developer, manufacturer and marketer of proprietary clinical ... media ("BioLife" or the "Company"), today announced that ... released after market close on Thursday, May 11, 2017, ... and live webcast at 1:30 p.m. PT that afternoon. ...
Breaking Medicine Technology: