Navigation Links
Genomic signature in post-menopausal women may explain why pregnancy reduces breast cancer risk
Date:4/5/2011

ORLANDO, FL (April 5, 2011) Women who have children, particularly early in life, have a lower lifetime risk of breast cancer compared with women who do not. Now, Fox Chase Cancer Center researchers have identified a gene expression pattern in breast tissue that differs between post-menopausal women who had children and post-menopausal women who did not. The results will help scientists understand why pregnancy reduces breast cancer risk and may help them develop chemopreventive strategies that can provide similar protection for women who did not have children.

Pregnancy triggers differentiation and growth of breast tissue; however breast tissue in post-menopausal women looks similar regardless of childbearing history. That similarity has left researchers wondering why pregnancy is protective throughout a woman's life. This study starts to explain that effect, says Ricardo Lpez de Cicco, PhD, a senior research associate at Fox Chase, who will present the work at the AACR 102nd Annual Meeting 2011 on Tuesday, April 5.

"When a woman has multiple pregnancies beginning at a relatively young age, we see a protective effect against breast cancer," Lopez says. "In this study, we identified a post-pregnancy genomic signature that can still be seen even after menopause. That is very important because it could begin to help us understand why women who have children early benefit from a reduced risk of breast cancer throughout their lives."

By comparing gene expression in breast tissue from 44 post-menopausal women who had children and 21 post-menopausal women who did not, the team identified 208 genes that are differentially expressed. The signature was subsequently validated in an independent cohort of 61 post-menopausal women, 38 who had children and 23 who did not.

"We are now quite sure that these 208 genes 305 transcripts represent the genomic signature of the effects of pregnancy," says Jose Russo, MD, director of the Breast
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New genomics research investigates metastatic childhood cancers
2. Promise of genomics research needs a realistic view
3. NHGRI charts course for the next phase of genomics research
4. Tufts University calls for moderate approach to teaching personalized genomic testing
5. Genomic markers may head off thousands of thyroid surgeries
6. Forces for cancer spread: Genomic instability and evolutionary selection
7. Genomic Systems announces moratorium on studying and treating terminal cancer has ended
8. La Jolla Institute to develop San Diegos first center for RNAi genomics research
9. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
10. St. Jude researcher receives grant to focus on cancer pharmacogenomics in children
11. New genomic marker for tuberculosis may help identify patients who will develop the disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 AttorneyOne.com, a recognized authority on ... from the FDA on Sit and Slim II . ... to purchase or use Sit and Slim II because it ... is promoted as weight loss product on various websites and ... market in 2010 for safety reasons, can significantly increase blood ...
(Date:10/20/2014)... October 20, 2014 Rockynol Retirement ... Center on Oct. 14. The $11 million project will ... and a cooked-to-order kitchen with full-service restaurant style dining. ... choice for first class Assisted Living apartments,” said Kara ... deserve the highest quality of care and this investment ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Based ... are the only imaging assays capable of determining ... single test.  With these three dimensions of high-resolution ... to detect the widest range of disease-causing genetic ... missed by other genomic tools, including today’s advanced ...
(Date:10/20/2014)... Final Cut Pro X Plugin developers from Pixel ... for FCPX filmmakers . , “Fun, cool, and simple ... theme” Says Christina Austin, CEO of Pixel Film Studios. “It ... Citrus comes with all the tools needed for a ... for added style, a title screen for an introduction, two ...
(Date:10/20/2014)... 2014 It’s hard to imagine what it’s ... vulnerable children around the world, it’s a reality. And while ... children are forced to walk barefoot on rocky terrain or ... play with their friends. , Buckner International's Shoes ... Radio in October to encourage support for Air1 and ...
Breaking Medicine News(10 mins):Health News:FDA Advises Not to Use Sit and Slim II: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3
... first book in nine years and the first about ... specific instructions for hunger-free weight loss with a fascinating, ... 28 Dr. Siegal,s Cookie Diet Book ... physician Sanford Siegal, D.O., M.D., will be available in ...
... every day from anesthesia over medication should be ... DEL MAR, Calif., April 28 Anesthesia over ... April issue of ,Anesthesiology, the official journal of ... mortality study of the 21st century.These deaths occurred ...
... buy Purell hand sanitizer that really works at up to 50% off ... ... a great effort to help stop the spread of the swine flu ... prices, today announced that it is further discounting all of its Purell ...
... and Sober Free Cab Ride Home" in Alameda, Oakland, Berkeley, and San Francisco ... ... with Veterans Cab and Yellow Cab of Alameda and with Luxor Cab in ... they don,t have a safe way home. The Safe and Sober Free ...
... it is joining the U.S. Department of Health and ... promoting National Women,s Health Week, which kicks off May ... to promote hearing health during National Hearing and Speech ... hearing test, the Across America Hearing Check Challenge ( ...
... Anesthetix Management, LLC ("Anesthetix"), recently marked a new milestone, expanding ... more hospitals are learning about and embracing Anesthetix, unique value ... national platform and local delivery model over a wide geographic ... ...
Cached Medicine News:Health News:Dr. Siegal's Cookie Diet Book by Physician, Author, and Weight-Loss Expert Sanford Siegal, D.O., M.D., Available May 22nd 2Health News:Dr. Siegal's Cookie Diet Book by Physician, Author, and Weight-Loss Expert Sanford Siegal, D.O., M.D., Available May 22nd 3Health News:Dr. Siegal's Cookie Diet Book by Physician, Author, and Weight-Loss Expert Sanford Siegal, D.O., M.D., Available May 22nd 4Health News:'Surgery, Anesthesia & Your Brain,' Not the Cache of 'Sex, Drugs, and Rock 'n Roll' 2Health News:ReStockIt.com Greatly Cutting Prices on Hand Sanitizers, Masks to Help Combat Swine Flu Epidemic 2Health News:California Injury Lawyer to Provide Free Cab Rides Home for Cinco de Mayo 2Health News:California Injury Lawyer to Provide Free Cab Rides Home for Cinco de Mayo 3Health News:Better Hearing Institute Joins HHS, Office on Women's Health in Promoting National Women's Health Week and Hearing Health 2Health News:Better Hearing Institute Joins HHS, Office on Women's Health in Promoting National Women's Health Week and Hearing Health 3Health News:Better Hearing Institute Joins HHS, Office on Women's Health in Promoting National Women's Health Week and Hearing Health 4Health News:Anesthetix Grows Practice Operations to 10 States 2
(Date:10/17/2014)... -- A victim of medical negligence at the hands of ... history of alcohol abuse, a physician and consumer advocates unveiled ... highlighting how Prop 46 will identify and deter physician substance ... The ad pictures a doctor drinking at a bar as ... will enact the first law in the nation requiring random ...
(Date:10/17/2014)... , Oct. 17, 2014 The ... Medical Technology Policy: The Green Park ... FDA, public and private payers, medical device and ... and other experts January 12, 2015 at its ... value of weight loss treatments.  Participants will discuss ...
(Date:10/17/2014)... Conn. , Oct. 17, 2014  UBM Medica ... online community for endocrinologists and other clinicians who treat ... comprehensive coverage on effective use of insulin .  ... eventually require insulin replacement therapy – daily ... for the progressive decline in the function of pancreatic ...
Breaking Medicine Technology:Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3
... , - Oralair(R) Grasses 300IR Highly Positive Clinical ... Chamber, Stallergenes S.A. announces the highly positive results ... (ACC)., The study on Oralair(R) Grasses included 86 ... durations: 1 week, 1 month,2 and 4 months without ...
... Ore., Aug. 26 The Oregon Tourism Commission,launched ... Training Program,(Q Care) this week on http://www.OregonQCare.com ... program created to support the tourism and,hospitality industry ... quality customer service, the training will equip,employees with ...
Cached Medicine Technology:Stallergenes: New Study VO 56 Highly Positive Results Conducted in an Allergen Challenge Chamber 2Stallergenes: New Study VO 56 Highly Positive Results Conducted in an Allergen Challenge Chamber 3Oregon Tourism Commission Unveils New Online Customer Service Training Program 2
... The compact Allegra X-22 Series is up to 10 ... a library of 11 rotors, the Allegra X-22 Series ... Features: Only 18 inches / 46 cm ... 22,065 x g 3 different ways to Spin ...
... Optimal for Subcellular Fractionation, ... x g (30,000 rpm) with ... from 0.25 up to 85 ... 2° C to 40° C ...
... to accommodate over 55 centrifuge tubes, bottles, ... labile samples. Incorporating the latest technology, these ... quick cooling from 22 C to 4 ... brushless motor, low pitch 62 dBA quiet ...
Inquire...
Medicine Products: