Navigation Links
Genomic profiling of lung tumors helps doctors choose most effective treatment
Date:9/28/2007

genes that were not expressed in tumors that were resistant to cisplatin, said senior author Anil Potti, M.D., an oncologist at Duke and a researcher in the IGSP. The reverse was true, as well; genes that were not expressed in tumors resistant to cisplatin seemed to be turned on in tumors that were sensitive to it.

The important second part of this project was to come up with a therapy option for the tumors that werent sensitive, Potti said.

Its one thing for a doctor to tell a patient that he wont respond to cisplatin, he said, but we have to know what to do when he asks what do you have for me"

The researchers then examined several common second-line therapies, such as a drug called pemetrexed which uses a different mechanism of action to attack NSCLC tumors.

We found the strongest inverse correlation between tumors that were sensitive to cisplatin and those that were sensitive to pemetrexed, Potti said. This suggests that some patients who are not likely to respond to cisplatin should perhaps be treated with pemetrexed first.

A clinical trial -- the first of its kind in lung cancer -- based on the findings of genomics studies is currently underway at Duke. These are not experimental drugs, we know they work, Potti said. Its just a matter of giving each patient the right one on the first try.

Almost 180,000 people are diagnosed with lung cancer each year in the United States, and about 160,000 patients die from the disease yearly, according to the American Cancer Society. Non-small cell lung cancer is the most common form of the disease -- accounting for 80 percent of all cases.

Almost half of NSCLC patients are found to have stage four disease, meaning the cancer has spread beyond the lung into other areas of the body. Currently, only 15 to 30 percent of people treated for stage four lung cancer will be alive a year later and only two percent are alive after five years, making this the deadliest
'/>"/>

Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Upcoming Hemogenomics Centre in Bangalore
2. Evoprinter, a multigenomic comparative tool for rapid identification of functionally important DNA
3. International Conference On Malaria - Laveran To Genomics
4. LINK Applied Genomics Programme Promises To Revolutionize Healthcare Systems
5. Nutrigenomics here comes a team to better your future!
6. Genomic tests for better cancer treatment
7. Web-Based Genomics Tool Designed to Help Predict Disease Susceptibility
8. AutoGenomics Addresses TB Crisis With a Genetic Drug Resistance Test
9. Pharmacogenomic Market Gaining Greater Acceptance Across Europe
10. Nutrient Profiling System Launched By Food Officials in UK
11. Proteomic Profiling Can Detect Preterm Birth Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... 2013 This week is National EMS ... efforts to provide the best emergency care and to ... week is also to educate the public that all ... Citizens are the first link, and a very important ... CPR after a cardiac arrest can triple a victim’s ...
(Date:5/24/2013)... Pomona, Calif. (PRWEB) May 24, 2013 ... has retained its status of “Full Accreditation” for the ... (AVMA) Council on Education (COE). , “This is a ... of our hard work and student outcomes,” said College ... want to express my appreciation to the faculty, staff, ...
(Date:5/24/2013)... The Mirena IUD lawyers at ... the FDA has received more than 59,229 complaints since 2004 ... intrauterine birth control device known as the Mirena IUD.* , ... by the women “included ‘expulsion,’ where the IUD came out ... according to an ABC News article. “Abdominal pain is also ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Gift ... Cards, major competitors in sustainable card material, are ... using forest materials as a sustainable gift card ... to identify industry challenges and increase education and ... programs to support the reduction of carbon footprint ...
(Date:5/24/2013)... failed to replicate what appeared to be breakthrough results ... were published last year in the journal Science ... suggested that the drug bexarotene (marketed as Targretin) could ... a pathological hallmark of Alzheimer,s disease in ... the 2012 report, drug treatment quickly removed most of ...
Breaking Medicine News(10 mins):Health News:Acadian Medics Reunite with Miracle Baby 2Health News:Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 3Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3
... SAN FRANCISCO, March 24 Epiphany Biosciences announced ... IND with the Food and Drug Administration (FDA) ... antiviral medication valomaciclovir (EPB-348) as an adjunctive therapy ... shown to possess potent antiviral activity in vitro ...
... Reverse Split Ratio of Outstanding Cellegy Common Stock Expected ... Cellegy Pharmaceuticals, Inc. (OTC Bulletin Board: CLGY) today announced ... Corporation approved the previously announced merger of the two ... The transaction, which is subject to customary closing ...
... and average selling prices to be affected into ... 24 According to Millennium Research Group,s (MRG,s) ... includes arthroplasty implants (shoulder, elbow, digit, ankle, and ... the double-digit market growth seen in recent years ...
... Calif., March 24 According to a new Harris ... being able to afford medical care and prescription medications.(1) ... children and working-age Americans went without needed prescription medications in ... in 2003. Experts predict these statistics are likely to ...
... Wuesthoff saves 16 percent system-wide on orthopedic spend , ... ... Wuesthoff Health System has renewed its supply chain relationship with Broadlane. ... of consumable supplies, equipment, pharmaceuticals and purchased services to help manage ...
... Regal International, Inc., doing business as Beauty ... by EMK Products, LLC to be the exclusive ... line. Under the agreement, Beauty Beverly Hills will ... and management of internet affiliates, marketing and sales.Beauty ...
Cached Medicine News:Health News:Epiphany Biosciences Initiates Program to Assess Valomaciclovir (EPB-348) as Adjunctive Therapy in Multiple Sclerosis (MS) 2Health News:Cellegy and Adamis Stockholders Approve Merger Transaction and Related Proposals 2Health News:Cellegy and Adamis Stockholders Approve Merger Transaction and Related Proposals 3Health News:Job Loss Means Fewer Americans Have Health Care Coverage: How Will the Economic Downturn Affect the Small-Joint Implant Market? 2Health News:*** Diabetes Alert Day *** OneTouch(R) Offers Cost Saving Tips to Help Diabetes Patients Maintain Good Health in Tough Economy 2Health News:*** Diabetes Alert Day *** OneTouch(R) Offers Cost Saving Tips to Help Diabetes Patients Maintain Good Health in Tough Economy 3Health News:*** Diabetes Alert Day *** OneTouch(R) Offers Cost Saving Tips to Help Diabetes Patients Maintain Good Health in Tough Economy 4Health News:Wuesthoff Health System and Broadlane Continue Exclusive Relationship; Orthopedic Consulting Initiative Yields Significant Savings 2Health News:Wuesthoff Health System and Broadlane Continue Exclusive Relationship; Orthopedic Consulting Initiative Yields Significant Savings 3Health News:Wuesthoff Health System and Broadlane Continue Exclusive Relationship; Orthopedic Consulting Initiative Yields Significant Savings 4Health News:EMK Placental Appoints Beauty Beverly Hills for Exclusive Distributorship. 2Health News:EMK Placental Appoints Beauty Beverly Hills for Exclusive Distributorship. 3
(Date:5/23/2013)... , May 24, 2013 3SBio ... the "Company"), a leading China ... and marketing biopharmaceutical products, announced today that, at ... the Company,s shareholders voted in favor of the ... agreement and plan of merger dated February 8, ...
(Date:5/23/2013)... PARÍS, 24 de mayo de 2013  Volcano ... desarrollador y fabricante de herramientas de precisión para ... tratamiento de la enfermedad vascular periférica y coronaria, ... ( Ad enosine V asodilator I ... durante la sesión de ensayo clínico hot line ...
(Date:5/23/2013)... , May 23, 2013 Amgen (NASDAQ: ... th Annual  Healthcare Conference on Thursday, May 30, 2013, ... , beginning at 9:20 a.m. Eastern Daylight Time. ... Amgen, will present at the conference. Live audio of the ... website, www.amgen.com , under Investors. A replay of the ...
Breaking Medicine Technology:3SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 4Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 5Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 6
... PALO ALTO, Calif., Feb. 9, 2011 Telik, Inc. (Nasdaq: ... Wick, M.D., Ph.D. will provide a corporate overview at the ... City on Tuesday, February 15 at 3:00 p.m. Eastern time ... A live and archived webcast of the presentation will be ...
... MATEO, Calif., Feb. 8, 2011 NeurogesX, Inc. (Nasdaq: ... developing and commercializing novel pain management therapies, announced today ... scheduled to present at two upcoming conferences in New ... Investor Conference, to be held February 14-15, 2011 at ...
Cached Medicine Technology:NeurogesX to Present at Two February Investor Conferences 2NeurogesX to Present at Two February Investor Conferences 3
... innovative capillary electrophoresis system is designed ... testing. The CAPILLARYS 2 utilizes liquid ... clinical diagnostic setting. Through continuous sample ... very narrow capillary tubes functioning concurrently, ...
... These unique Acid Fast Control ... smear with appropriate background material. ... a positive and negative smear. ... (Cat. No. 353), Ziehl-Neelsen or ...
PRINCIPLE: The QC-SLIDES™ are specifically designed microscope slides intended to be part of the quality control program to monitor microbiological stains and staining techniques....
Each slide contains Giardia lamblia trophozoites applied as a mono-layer to the side....
Medicine Products: