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Genomic 'markers' may head off thousands of thyroid surgeries
Date:11/23/2010

AURORA, Colo. (Nov. 22, 2010) Doctors at the University of Colorado School of Medicine were concerned recently when they found a nodule in the thyroid of a 64-year-old Colorado man. They extracted cells from the nodule, hoping to determine whether the man had cancer. But the biopsy results were inconclusive.

Even a few months ago, such uncertainty would have likely led to surgery to remove all or part of the thyroid. At least this patient would have faced a tense waiting period to see if, over time, he developed clear signs of cancer.

This time, however, the CU doctors simply sent the cell sample to a laboratory. There, a test analyzed the cells' molecular patterns, producing a result that was a relief for the patient: there was a high level of certainty he didn't have cancer.

The CU doctors are helping lead the way nationally in the use of this genomic approach to evaluating suspicious thyroid nodules. The test that benefitted the 64-year-old patient could eliminate the need for tens of thousands of unnecessary thyroid surgeries every year. The patient is willing to talk with reporters.

"This should allow many patients to avoid the cost, discomfort and risk of surgery," says Bryan Haugen, MD, who heads the Division of Endocrinology, Metabolism and Diabetes at the CU medical school.

Usually, when cells are extracted from suspicious nodules in the thyroid, they're found to be benign. No cancer. But here's the problem -- in 15-30 percent of those samples, it's hard to tell. The next step in most cases has been for a surgeon to remove part, or all, of the thyroid. That tissue is examined further. More than 70 percent of the time, there's no cancer, yet the patient had to undergo surgery to get that good news and is often subjected to lifelong thyroid hormone therapy as a result.

Haugen and the national team sought to determine if the new test could help avoid those surgeries and still identify when there'
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Contact: Dan Meyers
dan.meyers@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

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