Navigation Links
Genomic detectives crack the case of the missing heritability
Date:2/22/2013

Despite years of research, the genetic factors behind many human diseases and characteristics remain unknown. The inability to find the complete genetic causes of family traits such as height or the risk of type 2 diabetes has been called the "missing heritability" problem.

A new study by Princeton University researchers, however, suggests that missing heritability may not be missing after all at least not in yeast cells, which the researchers used as a model for studying the problem. Published in the journal Nature, the results suggest that heritability in humans may be hidden due only to the limitations of modern research tools, but could be discovered if scientists know where (and how) to look.

[Images can be seen at http://www.princeton.edu/main/news/archive/S36/13/86G93. To obtain high-res images, contact Princeton science writer Morgan Kelly, (609) 258-5729, mgnkelly@princeton.edu]

"The message of our study is that if you look hard enough you will find the missing heritability," said the senior researcher, Leonid Kruglyak, Princeton's William R. Harman '63 and Mary-Love Harman Professor in Genomics and a Howard Hughes Medical Institute Investigator. Kruglyak worked with first author Joshua Bloom, a Princeton graduate student; Wesley Loo, a 2010 Princeton graduate now a graduate student at Harvard University; Thuy-Lan Lite, Class of 2012, who is working at the National Institutes of Health for a year before starting graduate school; and Ian Ehrenreich, a past Princeton postdoctoral researcher now at the University of Southern California.

"We don't think there is some fundamental limitation such as that there are things we don't understand about how genes behave that is holding us back," Kruglyak said. "Instead, we should be able to detect the heritability in humans if we use the ri
'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Following the genomic pathways to stop the spread of cancer
2. Genomic study of rare childrens cancer yields possible prognostic tool
3. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
4. Study identifies genes associated with genomic expansions that cause disease
5. $8.9 million NIH grant to study genomic link to premature heart disease
6. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
7. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
8. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
9. Study shows large-scale genomic testing feasible, impacts therapy
10. Stanford/Yale study gives insight into subtle genomic differences among our own cells
11. NIH grant moves pathologists to the forefront of genomic medicine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genomic detectives crack the case of the missing heritability
(Date:9/30/2014)... conceived either less than one year or more than five ... increased risk for autism, a new study suggests. However, ... that the research can,t prove that birth spacing has any ... that parents understand that the odds for autism are still ... apart," said outside expert Dr. Andrew Adesman. He is chief ...
(Date:9/30/2014)... Alan Mozes ... (HealthDay News) -- Colon cancer patients who are overweight ... higher risk for developing a second weight-related cancer, new ... the risk of colon cancer recurrence, only the potential ... "We found that colorectal cancer survivors who reported being ...
(Date:9/30/2014)... Keystone Symposia will convene the first conference of ... Global Health Series on "The Modes of Action ... immediately following the conclusion of the Grand Challenges Meeting ... of the Keystone Symposia Global Health Series, supported by ... funded travel awards for 36 investigators from developing countries ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Integrated ... wellness, is opening another new medical specialty practice through ... IMA Cardiology will be located within the company’s ... Abbud and Dr. Isaac Tawfik of American Heart Center, ... The new practice will offer Integrated Medicine Alliance patients ...
(Date:9/30/2014)... been awarded a three-year $1.7 million grant from ... new imaging technologies and data analysis techniques that ... of neurons in the brain interact to process ... the precise interactions between millions of nerve cells ... alterations in these interactions that may be responsible ...
Breaking Medicine News(10 mins):Health News:Spacing Between Sibling Births Tied to Autism Risk in Study 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 3Health News:Keystone Symposia launches 2014-2015 meeting series with Global Health Vaccines Conference 2Health News:Integrated Medicine Alliance Announces New Cardiology Practice 2Health News:UMD receives inaugural BRAIN Initiative Award 2
... therapy, is a new treatment that provides proven pain relief and healing ... by The Laser Pain Management Center in Western Massachusetts. , ... Holyoke, ... affect on every aspect of daily life. Low level laser therapy (LLLT), ...
... Report identifies opportunities for improvement amidst high satisfaction levels , ... Wausau, ... its highest level since 2005, while workforce satisfaction is at its highest ... 2008 National Survey of Consumer and Workforce Satisfaction in Nursing Homes ...
... Food Safety, SET FOR July 14-16 BATTLE CREEK, ... Institute (IFPTI) announced today that it will deliver its ... Safety" -- on July 14-16, 2009 at the McCamly ... a non-profit organization established to deliver career-spanning certified food ...
... FOREVER DETROIT, May 26 Metro Detroiters have shown time ... their generosity and support for others is heartfelt and unwavering. ... world paint a somewhat bleak picture of Detroit and its ... rise above these challenges than right here in the Motor ...
... N.C., May 26 Cogdell Spencer Inc. (NYSE: ... offering of 18,000,000 shares of common stock. Cogdell Spencer ... up to an additional 2,700,000 shares of common stock. ... managers. , The Company intends to use the net proceeds ...
... Class Action Suit and Ad Campaign with Affected Californians, ... Seniors, people with disabilities and the ... live at home launched a statewide effort today to ... cuts with a 48-hour vigil at the State Capitol, ...
Cached Medicine News:Health News:New Non-Surgical Laser Treatment Helps Patients Live Pain Free 2Health News:New Non-Surgical Laser Treatment Helps Patients Live Pain Free 3Health News:Nursing Home Consumer, Workforce Satisfaction Reaches New Highs 2Health News:International Food Protection Training Institute to Deliver Inaugural Training Course to Food Safety Regulators 2Health News:International Food Protection Training Institute to Deliver Inaugural Training Course to Food Safety Regulators 3Health News:Metro Detroiters Step Up for the Susan G. Komen Detroit Race for the Cure(R), May 30 2Health News:Metro Detroiters Step Up for the Susan G. Komen Detroit Race for the Cure(R), May 30 3Health News:Metro Detroiters Step Up for the Susan G. Komen Detroit Race for the Cure(R), May 30 4Health News:Metro Detroiters Step Up for the Susan G. Komen Detroit Race for the Cure(R), May 30 5Health News:Cogdell Spencer Announces Commencement of Common Stock Offering 2Health News:Cogdell Spencer Announces Commencement of Common Stock Offering 3Health News:Senseless Budget Cuts Will Gut California's Cost Efficient Home Care Program and Force Seniors and People with Disabilities Out of Their Homes and into Institutions 2Health News:Senseless Budget Cuts Will Gut California's Cost Efficient Home Care Program and Force Seniors and People with Disabilities Out of Their Homes and into Institutions 3
(Date:9/30/2014)... -- The Chinese wound care market is in the ... incidence of lifestyle diseases, coupled with the increase in ... quality of wound care products provide the impetus for ... health insurance schemes and increased reimbursement rate for wound ... findings of primary and secondary researches, this research service ...
(Date:9/30/2014)... MOUNTAIN VIEW, Calif. , Sept. 30, 2014 /PRNewswire/ ... today, which integrates with HealthKit in iOS 8 and ... with their doctors. The app harnesses native iOS technologies ... patients to maintain a robust connection with their doctors ... wearable health devices and the data they collect is ...
(Date:9/30/2014)... YORK , Sept. 30, 2014 The ... stage. Both established medical-device providers as well as new ... European region, while simultaneously looking at ways to reduce ... sector. Using distributors is one of the effective means ... medical devices distribution market in Eastern European and provides ...
Breaking Medicine Technology:China Wound Care Market 2China Wound Care Market 3HealthLoop Integrates with Apple's HealthKit Enabling Patients to Share Health Data with Their Doctors Right from their iPhone 2Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3
... Healthcare Products Corporation ("Futuremed") (TSX: FMD) and Cardinal Health ... Cardinal Health, Inc. (NYSE: CAH ), announced ... letter, this morning regarding Cardinal Health Canada,s proposed acquisition ... of Futuremed for CAD $8.15 per Common Share in ...
... (Pinksheets: KLYG), is pleased to announce the 3rd and 4th ... medical device business. While Kelyniam only received the ... 2011, the company was thrilled to be able to receive ... our commercial launch in September.  Revenues for the 3rd quarter ...
Cached Medicine Technology:Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 2Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 3Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 4Kelyniam Global Inc. Reports 2011 3rd & 4th Quarter Financial Results 2Kelyniam Global Inc. Reports 2011 3rd & 4th Quarter Financial Results 3
Low temp, micro fine tip, patented Aaron RAM cauteries....
Aaron 2250 is a multipurpose electrosurgical generator with monoploar and bi-polar functions....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
Medicine Products: